Results 11 to 20 of about 60,743 (255)
Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8.
Mol Biochem Parasitol, 2010 Following a switch from variant surface glycoprotein MITat1.4 to variant surface glycoprotein MITat1.8 expression by Lister strain 427 Trypanosoma brucei brucei parasites, the latter uncharacterized variant surface glycoprotein was analysed. Variant surface glycoprotein MITat1.8 was found to be a disulphide-linked homodimer, containing a complex N ...
Mehlert A, Sullivan L, Ferguson MA.
europepmc +4 more sources
VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei
Frontiers in Cell and Developmental Biology, 2022 The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the mammalian host. In the insect, T. brucei undergoes several developmental stages until it reaches the salivary gland and differentiates into the metacyclic form, which ...
Eliane Tihon +6 more
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Evolution of the variant surface glycoprotein family in African trypanosomes [PDF]
Trends in Parasitology, 2022 An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies have revealed that the VSG repertoire has a complex evolutionary history.
Silva Pereira, Sara +2 more
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Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes
mSphere, 2022 A hallmark of eukaryotic cells is the ability to form a secretory pathway connecting many intracellular compartments. In the early secretory pathway, coated protein complex II (COPII)-coated vesicles mediate the anterograde transport of newly synthesized
Mohamed Sharif, James D. Bangs
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An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes
Nature Communications, 2022 A Variant Surface Glycoprotein (VSG) coat protects bloodstream form T. brucei. Applying super-resolution microscopy Budzak et al. characterize a set of nuclear bodies, which associate with the active expression site in bloodstream form T.
James Budzak +4 more
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Secondary structure of the variant surface glycoproteins of trypanosomes [PDF]
FEBS Letters, 1987 The secondary structure of seven variant surface glycoproteins (VSGs) of trypanosomes has been determined by Raman spectroscopy. They are all predominantly α‐helical, the α‐helix content varying between 50 and 60%. The β‐strand content varies between 20 and 25%, and the content of β‐turn and nonregular structures is about 25%.
Jähnig, Fritz +3 more
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A monocistronic transcript for a trypanosome variant surface glycoprotein. [PDF]
Molecular and Cellular Biology, 1994 Many protein-encoding genes of African trypanosomes are transcribed as large polycistronic pre-mRNAs that are processed into individual mRNAs containing a 5' spliced leader and 3' poly(A). The 45- to 60-kb pre-mRNAs encoding some variant surface glycoproteins (VSGs) contain as many as eight unrelated coding regions.
C M, Alarcon +3 more
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Microbiology Spectrum, 2022 Ebola virus, a member of the Filoviridae family, utilizes the attachment factors on host cells to support its entry and cause severe tissue damage. TIM-1 has been identified as a predominant attachment factor via interaction with phosphatidylserine (PS ...
Min Zhang +14 more
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A Short Series of Case Reports of COVID-19 in Immunocompromised Patients
Viruses, 2022 Immunocompromised individuals are at risk of prolonged SARS-CoV-2 infection due to weaker immunity, co-morbidities, and lowered vaccine effectiveness, which may evolve highly mutated variants of SARS-CoV-2.
Mitali Mishra +9 more
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Cell Reports, 2020 Summary: Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a time ...
Jennifer Ann Black +7 more
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