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Trypanosoma Variant Surface Glycoprotein: A Review
مجلة الانبار للعلوم البيطريةThe glycoprotein surface of the Trypanosoma parasite plays a crucial role in the organism’s biology, as a protective barrier that facility invasion to the host.
Kalef, Dalia Ahmed, Shather, Maulood M
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SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes. [PDF]
EMBO Rep, 2019 SUMOylation is a post-translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG). The presence of a highly SUMOylated focus associated with the nuclear body, where the VSG gene is transcribed, further suggests an important role of SUMOylation in regulating VSG expression.
Saura A +10 more
europepmc +6 more sources
Evolution of the variant surface glycoprotein family in African trypanosomes [PDF]
Trends in Parasitology, 2022 An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies have revealed that the VSG repertoire has a complex evolutionary history.
Silva Pereira, Sara +2 more
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Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes
mSphere, 2022 A hallmark of eukaryotic cells is the ability to form a secretory pathway connecting many intracellular compartments. In the early secretory pathway, coated protein complex II (COPII)-coated vesicles mediate the anterograde transport of newly synthesized
Mohamed Sharif, James D. Bangs
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An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes
Nature Communications, 2022 A Variant Surface Glycoprotein (VSG) coat protects bloodstream form T. brucei. Applying super-resolution microscopy Budzak et al. characterize a set of nuclear bodies, which associate with the active expression site in bloodstream form T.
James Budzak +4 more
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Secondary structure of the variant surface glycoproteins of trypanosomes [PDF]
FEBS Letters, 1987 The secondary structure of seven variant surface glycoproteins (VSGs) of trypanosomes has been determined by Raman spectroscopy. They are all predominantly α‐helical, the α‐helix content varying between 50 and 60%. The β‐strand content varies between 20 and 25%, and the content of β‐turn and nonregular structures is about 25%.
Jähnig, Fritz +3 more
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A monocistronic transcript for a trypanosome variant surface glycoprotein. [PDF]
Molecular and Cellular Biology, 1994 Many protein-encoding genes of African trypanosomes are transcribed as large polycistronic pre-mRNAs that are processed into individual mRNAs containing a 5' spliced leader and 3' poly(A). The 45- to 60-kb pre-mRNAs encoding some variant surface glycoproteins (VSGs) contain as many as eight unrelated coding regions.
C M, Alarcon +3 more
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Microbiology Spectrum, 2022 Ebola virus, a member of the Filoviridae family, utilizes the attachment factors on host cells to support its entry and cause severe tissue damage. TIM-1 has been identified as a predominant attachment factor via interaction with phosphatidylserine (PS ...
Min Zhang +14 more
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A Short Series of Case Reports of COVID-19 in Immunocompromised Patients
Viruses, 2022 Immunocompromised individuals are at risk of prolonged SARS-CoV-2 infection due to weaker immunity, co-morbidities, and lowered vaccine effectiveness, which may evolve highly mutated variants of SARS-CoV-2.
Mitali Mishra +9 more
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Cell Reports, 2020 Summary: Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a time ...
Jennifer Ann Black +7 more
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