Results 21 to 30 of about 60,743 (255)

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. [PDF]

PLoS Genetics, 2018
Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory receptor that recognizes specific O-glycosylated proteins and is expressed on various innate immune cell types including microglia.
Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graham   +14 more
doaj   +1 more source

Selective cleavage of variant surface glycoproteins from Trypanosoma brucei [PDF]

Biochemical Journal, 1979
Two conformationally distinct regions were revealed by tryptic cleavage of six undenatured variant surface glycoproteins purified from clones of Trypanosoma brucei. Within 5 min, the native glycoproteins (65,000 mol.wt.) were cleaved, yielding a large N-terminal fragment (48,000-55,000 mol.wt.
J G, Johnson, G A, Cross
openaire   +2 more sources

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

mBio, 2022
Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa.
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonné Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier   +9 more
doaj   +1 more source

Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Nature Communications, 2020
Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T.
Sara Silva Pereira, Kayo J. G. de Almeida Castilho Neto, Craig W. Duffy, Peter Richards, Harry Noyes, Moses Ogugo, Marcos Rogério André, Zakaria Bengaly, Steve Kemp, Marta M. G. Teixeira, Rosangela Z. Machado, Andrew P. Jackson   +11 more
doaj   +1 more source

Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. [PDF]

PLoS ONE, 2013
Hemagglutinin is the major surface glycoprotein of influenza viruses. It participates in the initial steps of viral infection through receptor binding and membrane fusion events.
Alicia Jiménez-Alberto, Esmeralda Alvarado-Facundo, Rosa María Ribas-Aparicio, Juan A Castelán-Vega   +3 more
doaj   +1 more source

Immunodominant surface epitopes power immune evasion in the African trypanosome

Cell Reports, 2023
Summary: The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we describe the antibody repertoires elicited by different VSGs.
Anastasia Gkeka, Francisco Aresta-Branco, Gianna Triller, Evi P. Vlachou, Monique van Straaten, Mirjana Lilic, Paul Dominic B. Olinares, Kathryn Perez, Brian T. Chait, Renata Blatnik, Thomas Ruppert, Joseph P. Verdi, C. Erec Stebbins, F. Nina Papavasiliou   +13 more
doaj   +1 more source

N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold

Nature Communications, 2016
How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N ...
Andreas J. W. Hartel, Marius Glogger, Nicola G. Jones, Wasim Abuillan, Christopher Batram, Anne Hermann, Susanne F. Fenz, Motomu Tanaka, Markus Engstler   +8 more
doaj   +1 more source

Escaping the immune system by DNA repair and recombination in African trypanosomes [PDF]

Open Biology, 2019
African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one.
Núria Sima, Emilia Jane McLaughlin, Sebastian Hutchinson, Lucy Glover   +3 more
doaj   +1 more source

Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes

Frontiers in Cell and Developmental Biology, 2022
The African trypanosome Trypanosoma brucei is a parasite of the mammalian bloodstream and tissues, where an antigenically variable Variant Surface Glycoprotein (VSG) coat protects it from immune attack.
James Budzak, Gloria Rudenko
doaj   +1 more source

Mutational sensitivity of D614G in spike protein of SARS-CoV-2 in Jordan

Biochemistry and Biophysics Reports, 2021
Background: Spike protein is the surface glycoprotein of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) necessary for the entry of the virus via the transmembrane receptors of the human respiratory cells causing COVID-19 disease.
Walid Al-Zyoud, Hazem Haddad
doaj   +1 more source