Results 31 to 40 of about 1,508,590 (281)
Expanding the proteome: A-to-I RNA editing provides an adaptive advantage
Proceedings of the National Academy of Sciences of the United States of America, 2023 RNA editing refers to the post-transcriptional modification of RNA sequences. Diverse eukaryotes are capable of mRNA editing, most commonly through enzymatic deamination of adenosine-to-inosine (A-to-I) (1–3).
Zachary A. Lewis
semanticscholar +1 more source
Genetics, 2022 Spore killers are meiotic drive elements that can block development of sexual spores in fungi. In the maize ear rot and mycotoxin-producing fungus Fusarium verticillioides, a spore killer called SkK has been mapped to a 102-kb interval of chromosome V ...
J. Lohmar +5 more
semanticscholar +1 more source
Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified.
Emily C. Freund +6 more
doaj +1 more source
BMC Research Notes, 2012 BackgroundA-to-I RNA editing is found in all phyla of animals and contributes to transcript diversity that may have profound impacts on behavior and physiology.
F. Rinkevich, P. Schweitzer, J. G. Scott
semanticscholar +2 more sources
Epitranscriptomic investigation of myopia-associated RNA editing in the retina
Frontiers in Neuroscience, 2023 Myopia is one of the most common causes of vision loss globally and is significantly affected by epigenetics. Adenosine-to-inosine (A-to-I RNA) editing is an epigenetic process involved in neurological disorders, yet its role in myopia remains ...
Xu-Bin Pan +24 more
doaj +1 more source
Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
BMC Genomics, 2023 Background RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine.
Benjamin Wales-McGrath +2 more
doaj +1 more source
Transcriptome analysis identification of A-to-I RNA editing in granulosa cells associated with PCOS
Frontiers in Endocrinology, 2023 BackgroundPolycystic ovary syndrome (PCOS) is a complex, multifactor disorder in women of reproductive age worldwide. Although RNA editing may contribute to a variety of diseases, its role in PCOS remains unclear.MethodsA discovery RNA-Seq dataset was ...
Fan-Sheng Kong +19 more
doaj +1 more source
EndoVIA for quantifying A-to-I editing and mapping the subcellular localization of edited transcripts. [PDF]
Methods EnzymolAdenosine-to-inosine (A-to-I) editing, catalyzed by adenosine deaminases acting on RNA (ADARs), is a prevalent post-transcriptional modification that is vital for numerous biological functions. Given that this modification impacts global gene expression, RNA localization, and innate cellular immunity, dysregulation of A-to-I editing has unsurprisingly ...
Quillin AL +4 more
europepmc +3 more sources
bioRxiv, 2018 A-to-I RNA editing is widespread in eukaryotic transcriptomes and plays an essential role in the creation of proteomic and phenotypic diversity. Loss of ADARs, the proteins responsible for A-to-I editing, results in lethality in mammals. In C.
Nabeel S Ganem +10 more
semanticscholar +1 more source
Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies
PLOS Computational Biology, 2023 Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Tomer D. Mann +3 more
openaire +4 more sources