Results 101 to 110 of about 40,232 (213)
The ABCC6 transporter : what lessons can be learnt from other ATP-binding cassette transporters? [PDF]
, 2013 ABC transporters represent a large family of ATP-driven transmembrane transporters involved in uni- or bidirectional transfer of a large variety of substrates.
De Paepe, Anne +2 more
core +2 more sources
Photochemistry and Photobiology, EarlyView.Verteporfin's subcellular localization governs its ability to deplete ATP. LysoPC‐conjugated VP accumulates in lysosomes and spares mitochondria, while liposomal and NanoVP formulations target mitochondria, where light activation triggers membrane depolarization and ATP depletion, overcoming resistance seen with free‐form VP. Abstract P‐glycoprotein (P‐
Idrisa Rahman +7 more
wiley +1 more source
Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]
Journal of Medical Biochemistry, 2018 Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran +10 more
doaj
Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model
Photochemistry and Photobiology, EarlyView.Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore +6 more
wiley +1 more source
Frontiers in Pharmacology, 2018 P-Glycoprotein (P-gp, Abcb1) plays a crucial role in drug disposition and functions by hydrolyzing ATP. However, little is known about the regulatory elements governing the transcription of the porcine Abcb1 gene.
Tingting Guo +7 more
doaj +1 more source
A critical view on abc transporters and their interacting partners in auxin transport [PDF]
, 2017 Different subclasses of ATP-binding cassette (ABC) transporters have been implicated in the transport of native variants of the phytohormone auxin.
Aryal, Bibek +3 more
core +1 more source
Medical Sciences, 2015 A) polymorphism influences steroid sex hormone-induced expression and function of P-gp, which may help to explain inter-patient differences in P-gp-mediated chemotherapy resistance in vivo.
Peng, Rui +3 more
openaire +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida +7 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
Pharmacokinetic and Pharmacogenetic aspects of drug-drug interactions between antiretroviral and anti-tuberculosis drugs in Ethiopian patients: Implication for optimization of TB-HIV co-treatment [PDF]
, 2013 TB and HIV are immuno-pathologically interacting epidemic infectious diseases affecting the lives of millions globally & sub-Saharan African region accounts the highest burden of both diseases.
Habtewolde Eyakem, Abiy
core +1 more source