Results 121 to 130 of about 40,232 (213)

Evaluation of QSAR and ligand enzyme docking for the identification of ABCB1 substrates [PDF]

, 2013
P-glycoprotein (P-gp) is an efflux pump that belongs to ATP-binding cassette (ABC) transporter family embedded in the membrane bilayer. P-gp is a polyspecific protein that has demonstrated its function as a transporter of hydrophobic drugs as well as ...
Ghafourian, T., Ojo, O., Osho, V., Sharifi, M.   +3 more
core  

Uncaria alkaloids reverse ABCB1-mediated cancer multidrug resistance

International Journal of Oncology, 2017
The overexpression of ATP-binding cassette (ABC) transporters is the main cause of cancer multidrug resistance (MDR), which leads to chemotherapy failure. Uncaria alkaloids are the major active components isolated from uncaria, which is a common Chinese herbal medicine.
Huang, Bao-Yuan, Zeng, Yu, Li, Ying-Jie, Huang, Xiao-Jun, Hu, Nan, Yao, Nan, Chen, Min-Feng, Yang, Zai-Gang, Chen, Zhe-Sheng, Zhang, Dong-Mei, Zeng, Chang-Qing   +10 more
openaire   +3 more sources

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 2, Page 120-130, March 2026.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used

Infection and Drug Resistance, 2022
Irma Olarte Carrillo,1 Christian Omar Ramos Peñafiel,2 Iveth Mendoza Salas,2 Rafael Cerón Maldonado,1 Anel Irais García Laguna,1 Adrián De la Cruz Rosas,1 Carlos Martinez Murrillo,2 Adolfo Martinez Tovar1 1Laboratorio de Biología Molecular, Servicio de ...
Olarte Carrillo I, Ramos Peñafiel CO, Mendoza Salas I, Cerón Maldonado R, García Laguna AI, De la Cruz Rosas A, Martinez Murrillo C, Martinez Tovar A   +7 more
doaj  

Development and Testing of an Owner‐Reported Outcome Measure of Clinical Signs and Quality of Life in Dogs Treated With Chemotherapy

Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 80-94, March 2026.
ABSTRACT Cancer is a leading cause of mortality in older dogs. Despite the prevalence of chemotherapy in canine oncology, a good understanding of owners' observations of side effects and clinical signs in real time is still lacking. Owners' perceptions and reporting of clinical signs play an important role in monitoring a dog's condition during ...
Jenny Harris, Katie Sutton, Quentin Fournier, Jo Armes, Emma Ream, Nicholas Bacon   +5 more
wiley   +1 more source

ABCB1-C3435T polymorphism and breast cancer risk: A case-control study and a meta-analysis [PDF]

, 2017
Purpose: To investigate the association of ABCB1-C3435T transition with breast cancer risk which was followed by a meta-analysis. Methods: In a case-control study we collected blood samples from 290 women (including 150 breast cancer patients and 140 ...
Karimian, M., Karimian, Z., Kheirkhah, D., Sharif, A., Sharif, M.R.   +4 more
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Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population [PDF]

Caspian Journal of Internal Medicine
Background: Allelic variants of genes encoding enzymes of the esterase system (CES1) and P-glycoprotein (ABCB1) can change the metabolism and pharmacokinetics of dabigatran.
Ayan Abdrakhmanov, Elena Zholdybayeva, Aizhana Shaimerdinova, Gulmira Kulmambetova, Svetlana Abildinova, Rustam Albayev, Gulnara Tuyakova, Elena Rib, Zhanasyl Suleimen, Zhanar Abdrakhmanova, Makhabbat Bekbossynova   +10 more
doaj  

Individualization of Immunosuppressive Therapy after Solid Organ Transplantation [PDF]

, 2014
__Abstract__ When an individual’s kidneys fail, there are three treatment options: hemodialysis, peritoneal dialysis or kidney transplantation. A successful kidney transplantation results in the best patient survival and a better quality of life ...
Bouamar, R. (Rachida)
core   +1 more source

Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors

Communications Chemistry
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resistance, yet current ABCB1 inhibitors have ...
Javier Yu Peng Koh, Yoko Itahana, Alexander Krah, Habib Mostafa, Mingmin Ong, Sahana Iwamura, Dona Mariya Vincent, Sabhashina Radha Krishnan, Weiying Ye, Pierre Wing Chi Yim, Tushar M. Khopade, Kunihiko Chen, Pui San Kong, Lin-Fa Wang, Roderick W. Bates, Yasuhisa Kimura, Rajesh Viswanathan, Peter J. Bond, Koji Itahana   +18 more
doaj   +1 more source

Studies on Genes Related to Copper Accumulation of the Fujian Oyster Crassostrea angulata [PDF]

, 2015
牡蛎是具有重要经济价值的海水养殖品种，在世界很多地区都有养殖。而我国牡蛎养殖产量居世界首位。同时，牡蛎对铜、锌等金属具有很强的富集能力，经常被用于指示河口污染情况。随着工业发展，近岸河口区遭受越来越严重的金属污染，铜就是其中非常有代表性的金属污染物。因此牡蛎对铜的超富集现象越来越被人们所关注。学者们发现牡蛎对铜富集存在非常大的个体差异，然而相关的研究却非常有限，特别是缺少分子机制的解析。对这一现象的深入研究不但可以探寻、丰富牡蛎铜富集相关机制，更可以为选育牡蛎不同金属富集能力品系提供理论依据 ...
史博
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