Results 11 to 20 of about 40,232 (213)
ABCB1 Regulates Immune Genes in Breast Cancer
Breast Cancer: Targets and Therapy, 2023 Han-Kun Chen,1 Yi-Ling Chen,2 Chih-Yang Wang,3,4 Wei-Pang Chung,5,6 Jung-Hua Fang,7 Ming-Derg Lai,8,9 Hui-Ping Hsu10 1Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan; 2Department of Health and Nutrition, Chia Nan University of Pharmacy and ...
Chen HK +6 more
doaj +4 more sources
Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance [PDF]
Frontiers in Pharmacology, 2020 Multidrug resistance (MDR) of tumor cells to chemotherapeutic agents is the main reason for the failure of cancer chemotherapy. Overexpression of ABCB1 transporter that actively pumps various drugs out of the cells has been considered a major ...
Xiaofang Luo +10 more
doaj +3 more sources
Cancers, 2023 ABCB1, also known as MDR1, is a gene that encodes P-glycoprotein (P-gp), a membrane-associated ATP-dependent transporter. P-gp is widely expressed in many healthy tissues—in the gastrointestinal tract, liver, kidney, and at the blood–brain barrier. P-gp works to pump xenobiotics such as toxins and drugs out of cells.
Katie T. Skinner +2 more
openaire +2 more sources
Pharmacogenetics of CYP3A5 in Pediatric Patients With Eosinophilic Esophagitis. [PDF]
Clin Transl SciABSTRACT Eosinophilic esophagitis (EoE) is an atopic inflammatory disease with limited treatment options. Though swallowed topical steroids are commonly used, they are not effective in all patients. We investigated the presence of CYP3A4/5 and ABCB1 (P‐glycoprotein) mRNA in esophageal tissue and its differential expression by genotype in pediatric ...
Noel-MacDonnell J +7 more
europepmc +2 more sources
Frontiers in Pharmacology, 2022 Palbociclib was approved by the United States Food and Drug Administration for use, in combination with letrozole, as a first-line treatment for estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) postmenopausal ...
Han Fu +9 more
doaj +1 more source
Pharmaceutics, 2020 The rat is one of the most commonly used animal models in pre-clinical studies. Limited information between the sexes and the effect of food consumption on the gastrointestinal (GI) physiology, however, is acknowledged or understood.
Liu Dou +7 more
doaj +1 more source
Low ABCB1 gene expression is an early event in colorectal carcinogenesis. [PDF]
PLoS ONE, 2013 The ABCB1/MDR1 gene product ABCB1/P-glycoprotein is implicated in the development of colorectal cancer (CRC). NFKB1 encodes transcription factors regulating expression of a number of genes including ABCB1. We have previously found association between the
Vibeke Andersen +7 more
doaj +1 more source
International Veterinary Epilepsy Task Force consensus proposal: Medical treatment of canine epilepsy in Europe [PDF]
, 2015 In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which ...
A Fischer +148 more
core +13 more sources
Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro. [PDF]
PLoS ONE, 2013 Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we
Daniela Cihalova +3 more
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