Results 81 to 90 of about 40,232 (213)
Рациональная фармакотерапия в кардиологии, 2016 Platelets play an important role in the pathogenesis of atherosclerosis. They are involved in atherosclerosis progression and thrombotic complications. That is why antiplatelet therapy is a necessary element of these complications prevention in patients ...
A. N. Meshkov
doaj +1 more source
Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]
, 2019 We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey +2 more
core +1 more source
Common genetic polymorphisms in the ABCB1 gene are associated with risk of major depressive disorder in male Portuguese individuals [PDF]
, 2014 Major depressive disorder (MDD) is a highly prevalent disorder, which has been associated with an abnormal response of the hypothalamus–pituitary–adrenal (HPA) axis.
Assis, Joana +11 more
core +2 more sources
Medicine Bulletin, EarlyView.This study elucidates the nephrotoxic mechanism of acetyl tributyl citrate (ATBC) by integrating network toxicology, machine learning, and single‑cell multi‑omics analysis to systematically decipher the molecular mechanisms and cell‑type‑specific regulatory networks underlying ATBC‑induced kidney injury. First, a protein‑protein interaction network was
Yimao Wu +5 more
wiley +1 more source
BMC CancerBackground ABCB1 overexpression is a key factor in causing multidrug resistance (MDR). As a result, it is crucial to discover effective medications against ABCB1 to overcome MDR.
Baojie Liu +9 more
doaj +1 more source
ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma
Cells, 2020 The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation, toxicity, and immunogenic cell death induced by the drug.
Dimas Carolina Belisario +11 more
doaj +1 more source
Use of photoimmunoconjugates to characterize ABCB1 in cancer cells
Nanophotonics, 2021 Accurate detection of ATP-binding cassette drug transporter ABCB1 expression is imperative for precise identification of drug-resistant tumors. Existing detection methods fail to provide the necessary molecular details regarding the functional state of ...
Liang Barry J. +3 more
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Medicine Advances, EarlyView.After analyzing the burden of leukemia in the elderly aged 60–89 years from 1990 to 2019 using the Global Burden of Disease database, we found that although the burden of chronic myeloid leukemia has decreased over the past 30 years, the burden of other types of leukemia has continued to increase to varying degrees.
Jing Wei, Qijian Feng, Ziyuan Lu
wiley +1 more source
Pharmacogenomics and Personalized Medicine, 2022 Chiara Jeiziner,1 Samuel S Allemann,1 Kurt E Hersberger,1 Henriette E Meyer zu Schwabedissen2 1Pharmaceutical Care Research Group, Department Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 2Biopharmacy, Department Pharmaceutical ...
Jeiziner C +3 more
doaj
Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma. [PDF]
, 2017 Inter-individual differences in toxic symptoms and pharmacokinetics of high-dose methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway.
Bertino +33 more
core +1 more source