Results 91 to 100 of about 118,565,731 (151)

Properties and kinetics of biliverdin reductase [PDF]

Biochemical Journal, 1971
P, O Carra, E, Colleran
openaire   +2 more sources

Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease

, 2011
Biliverdin reductase-A (BVR-A) is a pleiotropic enzyme involved in cellular stress responses. It not only transforms biliverdin-IX alpha into the antioxidant bilirubin-IX alpha but through its serine/threonine/tyrosine kinase activity is able to modulate
E. Head, Cesare Mancuso, M. Paul Murphy, D. Allan Butterfield, R. Sultana, D. A. Butterfield, Barone, Eugenio, DI DOMENICO, FABIO, Rukhsana Sultana, Mancuso, Cesare, Fabio Di Domenico, Elizabeth Head, M. P. Murphy, Eugenio Barone, C. Mancuso   +14 more
core   +1 more source

An Alternative to Biliverdin, Mesobiliverdin IXα and Mesobiliverdin-Enriched Microalgae: A Review on the Production and Applications of Mesobiliverdin-Related Products

Molecules
Despite attracting interest for decades due to its anti-inflammatory and antioxidant capabilities, the use of biliverdin IXα (BV) in medicine and agriculture is hampered by uncertain purity and limited availability.
Naveena Poudyal, Jon Y. Takemoto, Yuan-Yu Lin, Cheng-Wei T. Chang   +3 more
doaj   +1 more source

Bilirubin and the Yellow Players in Ferroptosis: A Delicate Balance in Human Health and Disease, with a Focus on the Liver, Cardiovascular System, and Brain

Biomolecules
Ferroptosis is a unique form of regulated lytic cell death driven by intracellular iron overload, excessive production of reactive oxygen species, failure of antioxidant defense systems, lipid peroxidation, and subsequent plasma membrane damage.
Camilla Dalla Verde, Libor Vitek, Claudio Tiribelli, Silvia Gazzin   +3 more
doaj   +1 more source

Identification of a bilirubin receptor that may mediate a component of cholestatic itch

eLife, 2019
Various pathologic conditions result in jaundice, a yellowing of the skin due to a buildup of bilirubin. Patients with jaundice commonly report experiencing an intense non-histaminergic itch.
James Meixiong, Chirag Vasavda, Dustin Green, Qin Zheng, Lijun Qi, Shawn G Kwatra, James P Hamilton, Solomon H Snyder, Xinzhong Dong   +8 more
doaj   +1 more source

Mechanistic and functional studies on biliverdin IXa reductase from the cyanobacterium synechocystis sp.PCC6803

, 2009
THESIS 8724The enzymes of heme metabolism and phycobilin biosynthesis in the cyanobacterium Synechocystis sp. PCC6803, along with their reducing partners, ferredoxin and ferredoxin reductase were produced through recombinant DNA techniques and displayed ...
Hayes, Jerrard Michael
core  

Biliverdin Amides Reveal Roles for Propionate Side Chains in Bilin Reductase Recognition and in Holophytochrome Assembly and Photoconversion

, 2016
Linear tetrapyrroles (bilins) perform important antioxidant and light-harvesting functions in cells from bacteria to humans. To explore the role of the propionate moieties in bilin metabolism, we report the semisynthesis of mono- and diamides of ...
Shelley S. Martin (1299066), Lixia Shang (2282110), J. Clark Lagarias (1299060), Nathan C. Rockwell (1299063)   +3 more
core   +1 more source

Tumor-Draining Lymph Secretome En Route to the Regional Lymph Node in Breast Cancer Metastasis

Breast Cancer: Targets and Therapy, 2020
Sulma I Mohammed,1,2 Odalys Torres-Luquis,1 Weidong Zhou,3 Nadia Attalah Lanman,1,2 Virginia Espina,3 Lance Liotta3 1Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA; 2Purdue University Center for Cancer Research ...
Mohammed SI, Torres-Luquis O, Zhou W, Lanman NA, Espina V, Liotta L   +5 more
doaj  

Biliverdin reductase-A is a key modulator in insulin signaling and metabolism

Trends in Endocrinology & Metabolism
Biliverdin reductase-A (BVRA) is a pleiotropic enzyme traditionally known for its antioxidant role in the heme degradation pathway. Recent findings have redefined BVRA as a master regulator of insulin signaling, acting as a kinase, scaffold, and redox-sensitive integrator of metabolic cues.
Tramutola, Antonella, Di Domenico, Fabio, Perluigi, Marzia, Barone, Eugenio   +3 more
openaire   +3 more sources

Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1.

, 2001
Biliverdin reductase catalyzes the reduction of biliverdin, the product of heme oxygenase (HO) activity, to bilirubin. The reductase is unique among all enzymes characterized to date in being dual pH/cofactor-dependent.
Tian J Huang, Nariman Panahian, James F Ewing, Mahin D Maines   +3 more
core