Results 81 to 90 of about 118,565,731 (151)

Bilirubin: an endogenous molecule with antiviral activity in vitro.

Frontiers in Pharmacology, 2012
Bilirubin-IX-alpha (BR) is the final product of heme metabolism through the heme oxygenase/biliverdin reductase (HO/BVR) system. Previous papers reported on the microbicidal effects of the HO by-products biliverdin-IX-alpha, carbon monoxide and iron ...
Rosaria eSantangelo, Cesare eMancuso, Simona eMarchetti, Enrico eDi Stasio, Giovambattista ePani, Giovanni eFadda   +5 more
doaj   +1 more source

Specificity of biliverdin reductase [PDF]

Biochemical Journal, 1970
E, Colleran, P O, Carra
openaire   +2 more sources

Biliverdin reductase-A mediates the beneficial effects of intranasal insulin in Alzheimer disease. [PDF]

, 2019
Impairment of biliverdin reductase-A (BVR-A) is an early event leading to brain insulin resistance in AD. Intranasal insulin (INI) administration is under evaluation as a strategy to alleviate brain insulin resistance; however, the molecular mechanisms ...
Butterfield DA, Triani, Francesca, Grassi C., Ripoli C, Ripoli, Cristian, Perluigi M, Barone, Eugenio, Di Domenico F., Gaetani S., Barone E., Cassano T, Tramutola, Antonella, Perluigi M., Gaetani S, Di Domenico, Fabio, Barone E, Triani F., Calcagnini, Silvio, Cassano, Tommaso, Gaetani, Silvana, Di Domenico F, Grassi, Claudio, Tramutola A., Ripoli C., Perluigi, Marzia, Calcagnini S., Triani F, Cassano T., Calcagnini S, Butterfield, D Allan, Tramutola A, Grassi C, Butterfield D.A.   +32 more
core   +1 more source

Molecular Modeling to Provide Insight into the Substrate Binding and Catalytic Mechanism of Human Biliverdin-IXα Reductase

, 2016
Human biliverdin-IXα reductase (hBVR-A) catalyzes the conversion of biliverdin-IXα to bilirubin-IXα in the last step of heme degradation and is a key enzyme in regulating a wide range of cellular responses.
Gang Fu (728533), Haining Liu (1328499), Robert J. Doerksen (1328514)   +2 more
core   +1 more source

Biliverdin reductase as a target in drug research and development: Facts and hypotheses

, 2021
Biliverdin reductase-A (BVR) catalyzes the reduction of heme-derived biliverdin into bilirubin, this latter being a powerful endogenous free radical scavenger.
Mancuso C., Cesare Mancuso
core   +1 more source

Epididymosomes: a heterogeneous population of microvesicles with multiple functions in sperm maturation and storage

Asian Journal of Andrology, 2015
Extracellular microvesicles present in the epididymal fluid have been named epididymosomes. Many epididymosome-associated proteins are transferred to spermatozoa during their maturation in the excurrent duct.
Robert Sullivan
doaj   +1 more source

Mechanistic studies on human liver Biliverdin-IX beta reductase

, 2006
THESIS 7976The reaction mechanism of human biliverdin-IX? reductase (BVR-B) has been investigated using a number of approaches. The preference for NADPH over NADH has been examined using site-directed mutagenesis. The crystal structure of BVR-B, reported
Browne, Seamus
core  

Anti-Inflammatory and Cell Signalling Effects of Biliverdin and Biliverdin Reductase

, 2014
Despite advances in medical care and research, sepsis still poses a great threat to the health of society and remains a major cause of mortality and morbidity throughout the world. The progression of sepsis is driven by inflammatory processes.
Bisht, Kavita
core   +1 more source

Biliverdin reductase A deficiency reveals sex- and brain region-specific vulnerability to high-fat diet feeding

Redox Biology
How the brain senses and responds to early metabolic stress, and why this process fails differently across sexes and regions, remains poorly understood.
Simona Lanzillotta, Valeria Sommella, Barbara Zulli, Anna Picca, Riccardo Calvani, Sara Pagnotta, Gabriele Paolozzi, Mathilde Charlier, Emanuele Marzetti, Flavia Agata Cimini, Maria Gisella Cavallo, Bindu D. Paul, D. Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Antonella Tramutola, Eugenio Barone   +16 more
doaj   +1 more source

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation

Neurobiology of Disease, 2014
Alzheimer disease (AD) is the most common form of dementia among the elderly and is characterized by progressive loss of memory and cognition. These clinical features are due in part to the increase of reactive oxygen and nitrogen species that mediate ...
Eugenio Barone, Fabio Di Domenico, Cesare Mancuso, D. Allan Butterfield   +3 more
doaj   +1 more source