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The Role of Caspase-1 and Caspase-4 in Modulating Gingival Epithelial Cell Responses to Aggregatibacter actinomycetemcomitans Infection [PDF]

Pathogens
Periodontitis is a chronic inflammatory disease characterized by bacterial infection and immune dysregulation. Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is a key pathogen linked to disease progression.
Kartheyaene Jayaprakash Demirel, Alessandra Neves Guimaraes, Isak Demirel   +2 more
doaj   +5 more sources

The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage [PDF]

Frontiers in Immunology, 2023
The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and activated in response to bacterial infections to carry out pyroptosis.
Mohamed Ghait, Shivalee N. Duduskar, Michael Rooney, Michael Rooney, Norman Häfner, Laura Reng, Bianca Göhrig, Philipp A. Reuken, Frank Bloos, Michael Bauer, Michael Bauer, Christoph Sponholz, Tony Bruns, Tony Bruns, Ignacio Rubio, Ignacio Rubio   +15 more
doaj   +5 more sources

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease [PDF]

Frontiers in Pharmacology, 2022
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract, associated with high levels of inflammatory cytokine production.
Aoife P. Smith, Emma M. Creagh
doaj   +2 more sources

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 [PDF]

The EMBO Journal
Caspase-4 and caspase-11 (CASP4/11) sense bacterial lipopolysaccharide (LPS). Currently available inhibitors of CASP4/11 also block the activity of caspase-1 (CASP1), which restricts their usefulness in the study of CASP4/11 functions, as well as their ...
Malvina Pizzuto, Mercedes Monteleone, Sabrina Sofia Burgener, Jakub Began, Melan Kurera, Jing Rong Chia, Emmanuelle Frampton, Joanna Crawford, Monalisa Oliveira, Kirsten M Kenney, Jared R Coombs, Masahiro Yamamoto, Si Ming Man, Petr Broz, Pablo Pelegrin, Kate Schroder   +15 more
doaj   +2 more sources

Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer’s Disease Pathologies [PDF]

Cells
Chronic periodontitis, driven by the keystone pathogen Porphyromonas gingivalis, has been increasingly associated with Alzheimer’s disease (AD) and AD-related dementias (ADRDs). However, the mechanisms through which P. gingivalis-lipopolysaccharide (LPS)-
Ambika Verma, Gohar Azhar, Pankaj Patyal, Xiaomin Zhang, Jeanne Y. Wei   +4 more
doaj   +2 more sources

The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli [PDF]

Scientific Reports, 2022
The inflammasome-associated proteins caspase-1, caspase-4 and NLRP3 have been emphasised to be essential in the host cell response during urinary tract infection (UTI) by regulating IL-1β release.
Anna Lindblad, Charlotte Johansson, Katarina Persson, Isak Demirel   +3 more
doaj   +2 more sources

Beclin1 controls caspase-4 inflammsome activation and pyroptosis in mouse myocardial reperfusion-induced microvascular injury [PDF]

Cell Communication and Signaling, 2021
Background Myocardial reperfusion injury is often accompanied by cell death and inflammatory reactions. Recently, pyroptosis is gradually recognized as pivotal role in cardiovascular disease.
Wenjing Sun, Hongquan Lu, Shujuan Dong, Rui Li, Yingjie Chu, Nan Wang, Yu Zhao, Yabin Zhang, Limeiting Wang, Lin Sun, Di Lu   +10 more
doaj   +2 more sources

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease [PDF]

Alzheimer’s Research & Therapy
Alzheimer’s disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for
Kylene P. Daily, Asmaa Badr, Mostafa Eltobgy, Shady Estfanous, Owen Whitham, Michelle H. Tan, Cierra Carafice, Kathrin Krause, Andrew McNamara, Kaitlin Hamilton, Samuel Houle, Spandan Gupta, Gauruv A. Gupta, Shruthi Madhu, Julie Fitzgerald, Abbey A. Saadey, Brooke Laster, Pearlly Yan, Amy Webb, Xiaoli Zhang, Maciej Pietrzak, Olga N. Kokiko-Cochran, Hazem E. Ghoneim, Amal O. Amer   +23 more
doaj   +2 more sources

Caspase-4 Has Potential Utility as a Colorectal Tissue Biomarker for Dysplasia and Early-Stage Cancer [PDF]

Gastro Hep Advances
Background and Aims: Colorectal cancer (CRC) is the second most deadly cancer globally. The rapidly rising incidence rate of CRC, coupled with increased diagnoses in individuals
Laura E. Kane, Brian Flood, Joan Manils, Donna E. McSkeane, Aoife P. Smith, Miriam Tosetto, Fatema Alalawi, Joanna Fay, Elaine Kay, Cara Dunne, Stephen McQuaid, Maurice B. Loughrey, Jacintha O’Sullivan, Elizabeth J. Ryan, Kieran Sheahan, Glen A. Doherty, Emma M. Creagh   +16 more
doaj   +2 more sources

Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study

Journal of Indian Society of Periodontology
Background: Periodontitis and diabetes are chronic diseases where inflammation plays a central role, with each condition exacerbating the other. Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes.
Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, John Ebinezer, Bhavishya Balachandran   +5 more
doaj   +2 more sources