Results 1 to 10 of about 153 (95)

CD2v Interacts with Adaptor Protein AP-1 during African Swine Fever Infection. [PDF]

PLoS ONE, 2015
African swine fever virus (ASFV) CD2v protein is believed to be involved in virulence enhancement, viral hemadsorption, and pathogenesis, although the molecular mechanisms of the function of this viral protein are still not fully understood.
Daniel Pérez-Núñez, Eduardo García-Urdiales, Marta Martínez-Bonet, María L Nogal, Susana Barroso, Yolanda Revilla, Ricardo Madrid   +6 more
doaj   +7 more sources

Identification of Linear B Cell Epitopes on CD2V Protein of African Swine Fever Virus by Monoclonal Antibodies

Microbiology Spectrum, 2022
The CD2-like (CD2V) protein is a crucial antigen of African swine fever virus (ASFV). CD2V interacts with the cellular AP-1 protein, participates in intracellular transport of virus, and induces neutralizing antibodies to partly protect swine from virus ...
Rui Jia, Gaiping Zhang, Yilin Bai, Hongliang Liu, Yumei Chen, Peiyang Ding, Jingming Zhou, Hua Feng, Mingyang Li, Yuanyuan Tian, Aiping Wang   +10 more
doaj   +3 more sources

An Intracellular Epitope of ASFV CD2v Protein Elicits Humoral and Cellular Immune Responses

Animals, 2023
The African swine fever virus (ASFV) causes high mortality in domestic pigs. ASFV encodes an important protein target for subunit vaccine development, CD2v, but its most effective immunological regions are not known.
Wenlong Lu, Yilin Bai, Shuai Zhang, Xuyang Zhao, Jiaxin Jin, Xiaojing Zhu, Rui Wang, Yanan Wu, Angke Zhang, Gaiping Zhang, Guoqing Zhuang, Aijun Sun   +11 more
doaj   +3 more sources

African Swine Fever Virus CD2v Protein Induces β-Interferon Expression and Apoptosis in Swine Peripheral Blood Mononuclear Cells [PDF]

Viruses, 2021
African swine fever (ASF) is a hemorrhagic disease of swine characterized by massive lymphocyte depletion in lymphoid tissues due to the apoptosis of B and T cells, a process likely triggered by factors released or secreted by infected macrophages.
Sabal Chaulagain, Gustavo A. Delhon, Sushil Khatiwada, Daniel L. Rock   +3 more
doaj   +3 more sources

Development and characterization of monoclonal antibodies against the extracellular domain of African swine fever virus structural protein, CD2v

Frontiers in Microbiology, 2022
African swine fever virus (ASFV), a DNA double-stranded virus with high infectivity and mortality, causing a devastating blow to the pig industry and the world economy. The CD2v protein is an essential immunoprotective protein of ASFV.
Siyuan Liu, Siyuan Liu, Peiyang Ding, Yongkun Du, Yongkun Du, Dongna Ren, Yilan Chen, Minghui Li, Minghui Li, Xueke Sun, Siqiao Wang, Zejie Chang, Ruiqi Li, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang   +16 more
doaj   +3 more sources

Development of an indirect ELISA for the identification of African swine fever virus wild-type strains and CD2v-deleted strains

Frontiers in Veterinary Science, 2022
African swine fever (ASF) is a potent infectious disease with detrimental effects on the global swine industry and no currently vaccine available. The emergence of low-virulence CD2v-deleted mutants manifested as non-hemadsorption (non-HAD) strains ...
Wenting Jiang, Wenting Jiang, Dawei Jiang, Dawei Jiang, Dawei Jiang, Lu Li, Lu Li, Bo Wan, Bo Wan, Bo Wan, Jiabin Wang, Jiabin Wang, Panpan Wang, Panpan Wang, Xuejian Shi, Xuejian Shi, Qi Zhao, Qi Zhao, Jinxing Song, Jinxing Song, Zixiang Zhu, Zixiang Zhu, Pengchao Ji, Pengchao Ji, Pengchao Ji, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang   +28 more
doaj   +3 more sources

Comparisons on soluble expression and immunoreactivity of African swine fever virus CD2v protein expressed by different prokaryotic expression vectors

浙江大学学报. 农业与生命科学版, 2023
The aim of this study was to systematically investigate the differences in the soluble expression level of the African swine fever virus (ASFV) CD2v protein by different prokaryotic expression vectors, and the immunoreactivities of the inclusion body and
FENG Mengke, WANG Xingbo, LIN Lulu, CUI Mingxian, YAN Yan, ZHOU Jiyong   +5 more
doaj   +2 more sources

The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity

Veterinary Research, 2023
African swine fever virus (ASFV) is a highly contagious and deadly virus that leads to high mortality rates in domestic swine populations. Although the envelope protein CD2v of ASFV has been implicated in immunomodulation, the molecular mechanisms ...
Min Zhang, Lilei Lv, Huaye Luo, Hongming Cai, Lingxue Yu, Yifeng Jiang, Fei Gao, Wu Tong, Liwei Li, Guoxin Li, Yanjun Zhou, Guangzhi Tong, Changlong Liu   +12 more
doaj   +3 more sources

Mammalian Cell-Line-Expressed CD2v Protein of African Swine Fever Virus Provides Partial Protection against the HLJ/18 Strain in the Early Infection Stage

Viruses, 2023
A cell line expressing the CD2v protein of ASFV was generated. The efficient expression of CD2v protein was determined by immunofluorescence and Western blotting. The CD2v protein was Ni-affinity purified from the supernatant of cell cultures.
Rong-Hong Hua, Jing Liu, Shu-Jian Zhang, Ren-Qiang Liu, Xian-Feng Zhang, Xi-Jun He, Dong-Ming Zhao, Zhi-Gao Bu   +7 more
doaj   +1 more source

The African Swine Fever Virus with MGF360 and MGF505 Deleted Reduces the Apoptosis of Porcine Alveolar Macrophages by Inhibiting the NF-κB Signaling Pathway and Interleukin-1β

Vaccines, 2021
African swine fever virus (ASFV) poses serious threats to the swine industry. The mortality rate of African swine fever (ASF) is 100%, and there is no effective vaccine currently available.
Qi Gao, Yunlong Yang, Weipeng Quan, Jiachen Zheng, Yizhuo Luo, Heng Wang, Xiongnan Chen, Zhao Huang, Xiaojun Chen, Runda Xu, Guihong Zhang, Lang Gong   +11 more
doaj   +1 more source