Results 1 to 10 of about 11,198,861 (420)

Imaging cell lineage with a synthetic digital recording system [PDF]

Science, 2020
Cell lineage plays a pivotal role in cell fate determination. Chow et al. demonstrate the use of an integrase-based synthetic barcode system called intMEMOIR, which uses the serine integrase Bxb1 to perform irreversible nucleotide edits.
Budde, Mark W., Cabrera, Maria, Cai, Long, Cho, Soomin, Chow, Ke-Huan K., Elowitz, Michael B., Frieda, Kirsten L., Granados, Alejandro A., Huang, Ting-hao, Koulena, Noushin, Lois, Carlos, Yoon, Shinae   +11 more
core   +2 more sources

Cell lineage visualisation [PDF]

Computer Graphics Forum, 2015
Cell lineages describe the developmental history of cell populations and are produced by combining time-lapse imaging and image processing. Biomedical researchers study cell lineages to understand fundamental processes, such as cell differentiation and ...
Andrienko, Bostock, Bray, Burch, Carpenter, Carpenter, Chen, Cheung, Davoli, Errington, Glauche, Gordon, Graham, Hamilton, Herman, Hsu, Hägerstrand, Jensen, Jones, Khan, Khan, Khan, Pommier, Prasad, Pretorius, Reingold, Sanchez, Santiago-Mozos, Scherf, Schulz, Sigal, Tufte, Tunkelang, Walter, Walter, Ware   +35 more
core   +4 more sources

Oligodendrocyte lineage cells and depression [PDF]

Molecular Psychiatry, 2020
AbstractDepression is a common mental illness, affecting more than 300 million people worldwide. Decades of investigation have yielded symptomatic therapies for this disabling condition but have not led to a consensus about its pathogenesis. There are data to support several different theories of causation, including the monoamine hypothesis ...
Butian Zhou, Zhongqun Zhu, Bruce R. Ransom, Xiaoping Tong   +3 more
openaire   +3 more sources

T‐cell lineage determination [PDF]

Immunological Reviews, 2010
Summary:  T cells originate from hematopoietic stem cells (HSCs) in the bone marrow but complete their development in the thymus. HSCs give rise to a variety of non‐renewing hematopoietic progenitors, among which a rare subset migrates to the thymus via the bloodstream.
J. Jeremiah Bell, Avinash Bhandoola, Qi Yang   +2 more
openaire   +2 more sources

Lineage dynamics of murine pancreatic development at single-cell resolution. [PDF]

, 2018
Organogenesis requires the complex interactions of multiple cell lineages that coordinate their expansion, differentiation, and maturation over time.
Byrnes, Lauren E, Gilchrist, Caroline L, Knox, Sarah M, Meyer, Nathaniel P, Sneddon, Julie B, Subramaniam, Meena, Tward, Aaron D, Wong, Daniel M, Ye, Chun J   +8 more
core   +2 more sources

Development of Dendritic-Cell Lineages [PDF]

Immunity, 2007
Dendritic cells (DCs) are a heterogenous population of bone-marrow-derived immune cells. Although all DCs share a common ability to process and present antigen to naive T cells for the initiation of an immune response, they differ in surface markers, migratory patterns, localization, and cytokine production. DCs were originally considered to be myeloid
Yong-Jun Liu, Li Wu
openaire   +3 more sources

Molecular Genetics of T Cell Development [PDF]

, 2005
T cell development is guided by a complex set of transcription factors that act recursively, in different combinations, at each of the developmental choice points from T-lineage specification to peripheral T cell specialization. This review describes the
Aifantis I, Allen JD, Alvarez JD, Anderson MK, Barndt R, Cooper CL, Durum SK, Fisher RC, Gadina M, Hsiang YH, Hsiang YH, Ishiguro A, Ivanov V, Izon DJ, Kishi H, Kohu K, Mao C, McCracken S, McKercher SR, Mullen AC, Nerlov C, Ohteki T, Rosenbauer F, Rothenberg EV, Schilham MW, Sikes ML, Spain LM, Zhang D-H   +27 more
core   +1 more source

Molecular recording of mammalian embryogenesis. [PDF]

, 2019
Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt, Chan, Michelle M, Grosswendt, Stefanie, Jones, Matthew G, Jost, Marco, Khodaverdian, Alex, Kretzmer, Helene, Meissner, Alexander, Norman, Thomas M, Quinn, Jeffrey J, Smith, Zachary D, Weissman, Jonathan S, Yang, Dian, Yosef, Nir   +13 more
core   +2 more sources

Advances in cell lineage reprogramming [PDF]

Science China Life Sciences, 2013
As a milestone breakthrough of stem cell and regenerative medicine in recent years, somatic cell reprogramming has opened up new applications of regenerative medicine by breaking through the ethical shackles of embryonic stem cells. However, induced pluripotent stem (iPS) cells are prepared with a complicated protocol that results in a low ...
Junnian Zhou, Wen Yue, Xuetao Pei
openaire   +2 more sources

Systemic mastocytosis with associated myeloproliferative disease and precursor B lymphoblastic leukaemia with t(13;13)(q12;q22) involving FLT3. [PDF]

, 2008
Systemic mastocytoses represent neoplastic proliferations of mast cells. In about 20% of cases systemic mastocytoses are accompanied by clonal haematopoietic non-mast cell-lineage disorders, most commonly myeloid neoplasms.
Dirnhofer, S., Horny, H.-P., Jotterand, M., Muhlematter, D., Sotlar, Karl, Theocharides, A., Tzankov, A., Went, P.   +7 more
core   +1 more source