Results 1 to 10 of about 400,889 (317)

Cell Lineage Affiliation During Hematopoiesis. [PDF]

Int J Mol Sci
By the mid-1960s, hematopoietic stem cells (HSCs) were well described. They generate perhaps the most complex array of functionally mature cells in an adult organism. HSCs and their descendants have been studied extensively, and findings have provided principles that have been applied to the development of many cell systems.
Brown G.
europepmc   +3 more sources

A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage. [PDF]

Genes Dev
Matias NR, Gallicchio L, Lu D, Kim JJ, Perez J, Detweiler AM, Lu C, Bolival B, Fuller MT.   +8 more
europepmc   +3 more sources

Three-dimensional molecular architecture of mouse organogenesis

Nature Communications, 2023
Mammalian embryos exhibit sophisticated cellular patterning that is intricately orchestrated at both molecular and cellular level. It has recently become apparent that cells within the animal body display significant heterogeneity, both in terms of their
Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng   +19 more
doaj   +1 more source

BMP4 drives primed to naïve transition through PGC-like state

Nature Communications, 2022
Multiple pluripotent states have been described in mouse and human stem cells. Here the authors describe trajectories during BMP4 induced primed to naïve transition, which bifurcates into naïve and trophoblast-like branches with a PGC-like intermediate ...
Shengyong Yu, Chunhua Zhou, Jiangping He, Zhaokai Yao, Xingnan Huang, Bowen Rong, Hong Zhu, Shijie Wang, Shuyan Chen, Xialian Wang, Baomei Cai, Guoqing Zhao, Yuhan Chen, Lizhan Xiao, He Liu, Yue Qin, Jing Guo, Haokaifeng Wu, Zhen Zhang, Man Zhang, Xiaoyang Zhao, Fei Lan, Yixuan Wang, Jiekai Chen, Shangtao Cao, Duanqing Pei, Jing Liu   +26 more
doaj   +1 more source

Structure Insights Into Photosystem I Octamer From Cyanobacteria

Frontiers in Microbiology, 2022
The diversity of photosystem oligomers is essential to understanding how photosynthetic organisms adapt to light conditions. Due to its structural and physiological significance, the assembly of the PSI supercomplex has been of great interest recently in
Ming Chen, Yujie He, Dongyang Liu, Lijin Tian, Pengqi Xu, Xuan Liu, Yihang Pan, Shuqi Dong, Shuqi Dong, Jun He, Jun He, Ying Zhang   +11 more
doaj   +1 more source

Lung development and regeneration: newly defined cell types and progenitor status

Cell Regeneration, 2023
The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the lung vulnerable to injury.
Xiaogao Meng, Guizhong Cui, Guangdun Peng   +2 more
doaj   +1 more source

Control of RNA degradation in cell fate decision

Frontiers in Cell and Developmental Biology, 2023
Cell fate is shaped by a unique gene expression program, which reflects the concerted action of multilayered precise regulation. Substantial research attention has been paid to the contribution of RNA biogenesis to cell fate decisions.
Mingqiang Deng, Mingqiang Deng, Xiwei Wang, Zhi Xiong, Zhi Xiong, Peng Tang   +5 more
doaj   +1 more source

scDIOR: single cell RNA-seq data IO software

BMC Bioinformatics, 2022
Background Single-cell RNA sequencing is becoming a powerful tool to identify cell states, reconstruct developmental trajectories, and deconvolute spatial expression.
Huijian Feng, Lihui Lin, Jiekai Chen
doaj   +1 more source

T‐cell lineage determination [PDF]

Immunological Reviews, 2010
Summary:  T cells originate from hematopoietic stem cells (HSCs) in the bone marrow but complete their development in the thymus. HSCs give rise to a variety of non‐renewing hematopoietic progenitors, among which a rare subset migrates to the thymus via the bloodstream.
Qi, Yang, J, Jeremiah Bell, Avinash, Bhandoola   +2 more
openaire   +2 more sources

Monocyte–Macrophage Lineage Cell Fusion

International Journal of Molecular Sciences, 2022
Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs).
Kloc, Malgorzata, Subuddhi, Arijita, Uosef, Ahmed, Kubiak, Jacek, Ghobrial, Rafik M.   +4 more
openaire   +3 more sources