Results 91 to 100 of about 11,198,861 (420)

Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy

Clinical and Translational Medicine
Background Immunotherapy has emerged as a crucial treatment modality for solid tumours, yet tumours often evade immune surveillance. There is an imperative to uncover novel immune regulators that can boost tumour immunogenicity and increase the efficacy ...
Kaixin Wu, Sa Li, Guangliang Hong, Hongzhi Dong, Tongke Tang, He Liu, Lingmei Jin, Siyuan Lin, Jingyun Ji, Mingli Hu, Shuntian Chen, Haoyuan Wu, Guanzheng Luo, Haoyuan Wu, Xiangqian Kong, Jiekai Chen, Jiangping He, Hongling Wu   +17 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

A workflow to process 3D+time microscopy images of developing organisms and reconstruct their cell lineage

Nature Communications, 2016
The quantitative and systematic analysis of embryonic cell dynamics from in vivo 3D+time image data sets is a major challenge at the forefront of developmental biology.
E. Faure, T. Savy, B. Rizzi, C. Melani, O. Stasová, Dimitri Fabrèges, Robert Spir, M. Hammons, R. Čunderlík, G. Recher, B. Lombardot, L. Duloquin, I. Colin, Jozef Kollár, Sophie Desnoulez, P. Affaticati, B. Maury, A. Boyreau, Jean-Yves Nief, P. Calvat, P. Vernier, M. Frain, G. Lutfalla, Y. Kergosien, P. Suret, M. Remesíková, R. Doursat, A. Sarti, K. Mikula, N. Peyriéras, P. Bourgine   +30 more
semanticscholar   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Ancestral reproductive bias in branching processes [PDF]

arXiv, 2022
Consider a branching process with a homogeneous reproduction law. Sampling a single cell uniformly from the population at a time $T > 0$ and looking along the sampled cell's ancestral lineage, we find that the reproduction law is heterogeneous - the expected reproductive output of ancestral cells on the lineage from time $0$ to time $T$ continuously ...
arxiv  

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate [PDF]

, 2016
The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following Notch1-dependent T-cell lineage specification during which the first T-cell lineage genes are ...
Damle, Sagar, De Medts, Jelle, De Mulder, Katrien, De Smedt, Magda, Dolens, Anne-Catherine, Durinck, Kaat, Kerre, Tessa, Leclercq, Georges, Plum, Jean, Rothenberg, Ellen V, Speleman, Franki, Taghon, Tom, Van de Walle, Inge, Van Loocke, Wouter, Van Vlierberghe, Pieter, Vandekerckhove, Bart, Velghe, Imke, Waegemans, Els   +17 more
core   +2 more sources

MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy

Cell Reports, 2023
Summary: Autophagy is a fundamental biological process critical to all eukaryotic cellular life. Although autophagy has been increasingly studied, how its process is precisely coordinated remains an open question. ATG14 (ATG14L/Barkor) is known to play a
Xue Shi, Wenfeng Wu, Zhenhuan Feng, Peiyang Fan, Ruona Shi, Xiaofei Zhang   +5 more
doaj  

Mechanisms of radial glia progenitor cell lineage progression

FEBS Letters, 2017
The mammalian cerebral cortex is responsible for higher cognitive functions such as perception, consciousness, and acquiring and processing information. The neocortex is organized into six distinct laminae, each composed of a rich diversity of cell types
R. Beattie, S. Hippenmeyer
semanticscholar   +1 more source

Single-Cell Resolution of Lineage Trajectories in the Arabidopsis Stomatal Lineage and Developing Leaf

bioRxiv, 2020
Dynamic cell states underlie flexible developmental programs, such as with the stomatal lineage of the Arabidopsis epidermis. Initial stages of the lineage feature asynchronous and indeterminate divisions modulated by environmental cues, enabling cell ...
Camila B. Lopez-Anido, Anne Vatén, N. K. Smoot, Nidhi Sharma, Victoria Guo, Yan Gong, M. X. Anleu Gil, Annika K. Weimer, D. Bergmann   +8 more
semanticscholar   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source