Results 91 to 100 of about 400,889 (317)

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

, 2023
Demetra P. Kelenis, Kathia E. Rodarte, Rahul K. Kollipara, Karine Pozo, Shreoshi Pal Choudhuri, Kyle B. Spainhower, Sarah J. Wait, Victor Stastny, Trudy G. Oliver, Jane E. Johnson   +9 more
openalex   +1 more source

Cell Lineage Trees Bear Fruit [PDF]

Cell Systems, 2016
Two inference approaches harness the information present in cell lineage trees to better understand the dynamic transitions between cell states.
openaire   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Epigenetic reshaping through damage: promoting cell fate transition by BrdU and IdU incorporation

Cell & Bioscience
Background Thymidine analogs have long been recognized for their ability to randomly incorporate into DNA. However, the precise mechanisms through which thymidine analogs facilitate cell fate transition remains unclear.
Chuang Li, Xiaoduo Xu, Shuyan Chen, Anchun Xu, Tongxing Guan, Haokaifeng Wu, Duanqing Pei, Jing Liu   +7 more
doaj   +1 more source

Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit

eLife, 2019
The insect central complex (CX) is a conserved brain region containing 60 + neuronal subtypes, several of which contribute to navigation. It is not known how CX neuronal diversity is generated or how developmental origin of subtypes relates to function ...
Luis F Sullivan, Timothy L Warren, Chris Q Doe   +2 more
doaj   +1 more source

Autosomal Recessive Spastic Ataxia of Charlevoix‐Saguenay in Two Half‐Siblings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Autosomal recessive spastic ataxia of Charlevoix‐Saguenay (ARSACS) is caused by biallelic pathogenic variants in the SACS gene. We report the clinical, radiologic and neurophysiologic features of a pair of half‐siblings who presented with progressive cerebellar ataxia, peripheral neuropathy and upper motor neuron signs.
Dennis Yeow, Matthew Katz, Jonathan Rodgers, Mark Davis, Thomas Robertson, R. J. McKinlay Gardner, Pamela A. McCombe   +6 more
wiley   +1 more source

Dissecting endothelial cell heterogeneity with new tools

Cell Regeneration
The formation of a blood vessel network is crucial for organ development and regeneration. Over the past three decades, the central molecular mechanisms governing blood vessel growth have been extensively studied.
Jing Zhong, Rong-rong Gao, Xin Zhang, Jia-xin Yang, Yang Liu, Jinjin Ma, Qi Chen   +6 more
doaj   +1 more source

Modeling mixed-lineage-rearranged leukemia initiation in CD34 ⁺ cells: a “CRISPR” solution [PDF]

, 2017
Raúl Torres, Sandra Rodríguez, Clara Bueno, Pablo Menéndez   +3 more
openalex   +1 more source

Oropharyngeal Squamous Cell Carcinoma Morphology and Subtypes by Human Papillomavirus Type and by 16 Lineages and Sublineages

, 2021
James S. Lewis, Kari G. Rabe, Ping Liu, Xiaowei Wang, William D. Dupont, W. Dale Plummer, Maísa Pinheiro, Meredith Yeager, Joseph F. Boland, Michael Cullen, Mia Steinberg, Sara Bass, Mitra Mehrad, Connor J. O'Boyle, Maoxuan Lin, Daniel L. Faden, Krystle A. Lang-Kuhs   +16 more
openalex   +2 more sources