Results 101 to 110 of about 11,198,861 (420)

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]

, 2013
It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren, Seddon, Benedict, Sinclair, Charles, Yates, Andrew J.   +3 more
core   +1 more source

Enhancing human ACE2 expression in mouse models to improve COVID‐19 research

FEBS Open Bio
Mice are one of the most common biological models for laboratory use. However, wild‐type mice are not susceptible to COVID‐19 infection due to the low affinity of mouse ACE2, the entry protein for SARS‐CoV‐2.
Sun Jiaoyang, Cheng Shaofei, Hong Guangliang, Quan Xiongzhi, Lin Haofeng, Mao Rui, Johannes Grillari, Shi Zheng‐Li, Chen Jiekai, Liu Meiqin, Wu Haoyu, Wu Guangming   +11 more
doaj   +1 more source

A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution

Science, 2019
Identifying terminal nematode cells Single-cell RNA sequencing provides the power to identify the developmental trajectory of an organism. However, identifying the temporal lineage of cell development can be difficult without large-scale analyses. Packer
Jonathan S. Packer, Qin Zhu, C. Huynh, P. Sivaramakrishnan, E. Preston, Hannah Dueck, D. Stefanik, Kai Tan, C. Trapnell, Junhyong Kim, R. Waterston, J. Murray   +11 more
semanticscholar   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape

Frontiers in Immunology
BackgroundAlthough immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.MethodsWe retrieved the germline sequences for the IGHV from the ...
Weiqi Deng, Weiqi Deng, Xuefeng Niu, Ping He, Ping He, Qihong Yan, Qihong Yan, Huan Liang, Yongping Wang, Yongping Wang, Lishan Ning, Lishan Ning, Zihan Lin, Zihan Lin, Yudi Zhang, Xinwei Zhao, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen, Ling Chen   +20 more
doaj   +1 more source

Plectus - a stepping stone in embryonic cell lineage evolution of nematodes

EvoDevo, 2012
Background Recent studies have challenged the widespread view that the pattern of embryogenesis found in Caenorhabditis elegans (clade 9) is characteristic of nematodes in general.
Schulze Jens, Houthoofd Wouter, Uenk Jana, Vangestel Sandra, Schierenberg Einhard   +4 more
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Lineage EM Algorithm for Inferring Latent States from Cellular Lineage Trees [PDF]

arXiv, 2018
Phenotypic variability in a population of cells can work as the bet-hedging of the cells under an unpredictably changing environment, the typical example of which is the bacterial persistence. To understand the strategy to control such phenomena, it is indispensable to identify the phenotype of each cell and its inheritance.
arxiv  

The roles of ERAS during cell lineage specification of mouse early embryonic development [PDF]

Open Biology, 2015
Eras encodes a Ras-like GTPase protein that was originally identified as an embryonic stem cell-specific Ras. ERAS has been known to be required for the growth of embryonic stem cells and stimulates somatic cell reprogramming, suggesting its roles on ...
Zhen-Ao Zhao, Yang Yu, Huai-Xiao Ma, Xiao-Xiao Wang, Xukun Lu, Yanhua Zhai, Xiaoxin Zhang, Haibin Wang, Lei Li   +8 more
doaj   +1 more source

A generic, cost-effective, and scalable cell lineage analysis platform

Genome Research, 2016
Advances in single-cell genomics enable commensurate improvements in methods for uncovering lineage relations among individual cells. Current sequencing-based methods for cell lineage analysis depend on low-resolution bulk analysis or rely on extensive ...
Tamir Biezuner, A. Spiro, Ofir Raz, Shiran Amir, Lilach Milo, R. Adar, N. Chapal-Ilani, Veronika Berman, Yael Fried, E. Ainbinder, Galit Cohen, H. Barr, R. Halaban, E. Shapiro   +13 more
semanticscholar   +1 more source