Results 31 to 40 of about 11,198,861 (420)
A large deviation principle linking lineage statistics to fitness in microbial populations [PDF]
Phys. Rev. Lett. 125, 048102 (2020), 2020 In exponentially proliferating populations of microbes, the population typically doubles at a rate less than the average doubling time of a single-cell due to variability at the single-cell level. It is known that the distribution of generation times obtained from a single lineage is, in general, insufficient to determine a population's growth rate. Is
arxiv +1 more source
Single-cell lineage tracing unveils a role for Tcf15 in haematopoiesis
Nature, 2020 Bone marrow transplantation therapy relies on the life-long regenerative capacity of haematopoietic stem cells (HSCs)1,2. HSCs present a complex variety of regenerative behaviours at the clonal level, but the mechanisms underlying this diversity are ...
Alejo E. Rodriguez-Fraticelli +8 more
semanticscholar +1 more source
Diversity Among Cyanobacterial Photosystem I Oligomers
Frontiers in Microbiology, 2022 Unraveling the oligomeric states of the photosystem I complex is essential to understanding the evolution and native mechanisms of photosynthesis. The molecular composition and functions of this complex are highly conserved among cyanobacteria, algae ...
Ming Chen +10 more
doaj +1 more source
Cell lineage-specific transcriptome analysis for interpreting cell fate specification of proembryos
Nature Communications, 2020 In Arabidopsis, a zygote undergoes asymmetrical cell division that establishes the first two distinct cell types of early proembryos, apical and basal cells.
Xuemei Zhou +4 more
semanticscholar +1 more source
Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases [PDF]
, 2006 Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for ...
Abraham +33 more
core +1 more source
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985 Fixed lineages are the extreme manifestation of the interrelations between cell division pattern, spatial organization and cell differentiation occurring in embryonic development. These relationships are discussed in the light of recent new detailed descriptions of lineages, experimental perturbations and genetic analysis.
openaire +3 more sources
Cell Regeneration, 2021 Forkhead box (Fox) transcription factors play important roles in mammalian development and disease. However, their function in mouse somatic cell reprogramming remains unclear.
Meijun Fu +15 more
doaj +1 more source
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. [PDF]
, 2018 The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female.
Abe +111 more
core +2 more sources
A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS
eLife, 2021 The mechanisms specifying neuronal diversity are well characterized, yet it remains unclear how or if these mechanisms regulate neural circuit assembly.
Brandon Mark +8 more
doaj +1 more source
Monte-Carlo Simulation of a Multi-Dimensional Switch-Like Model of Stem Cell Differentiation [PDF]
Theory and Applications of Monte Carlo Simulations, ed. Charles J.
Mode, Intech, 2011, ISBN: 978-953-307-427-6, 2013 The process controlling the diferentiation of stem, or progenitor, cells into one specific functional direction is called lineage specification. An important characteristic of this process is the multi-lineage priming, which requires the simultaneous expression of lineage-specific genes.
arxiv +1 more source