Results 81 to 90 of about 4,109 (159)

A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors

Class A G protein-coupled receptors (GPCRs), a superfamily of cell membrane signaling receptors, moonlight as constitutively active phospholipid scramblases.
Khelashvili, G, Son, Y, Menon, I, Lee, J, Menon, AK, Morizumi, T, Sych, T, Levitz, J, Ernst, OP, Sezgin, E,   +9 more
core   +1 more source

Molecular Mechanism of Lipid and Ion Transport in Phospholipid Scrambling

, 2018
From bacteria to mammals, different phospholipid species are segregated between the inner and outer leaflets of the cellular membrane by adenosine triphosphate (ATP)-dependent lipid transporters.
Jiang, Tao
core   +1 more source

Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane

, 2001
Mammalian sperm cells are activated prior to fertilization by high bicarbonate levels, which facilitate lipoprotein-mediated cholesterol efflux. The role of bicarbonate and cholesterol acceptors on the cholesterol organization in the sperm plasma ...
Brouwers, JF, Flesch, Fredericus, van Golde, LM, Colenbrander, B, Nievelstein, PF, Verkleij, AJ, Gadella, BM   +6 more
core  

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling and swelling [PDF]

, 2016
The Scott syndrome is characterized as a mild bleeding disorder associated with a low prothrombin consumption in blood. Platelets from Scott patients show a defect in Ca2+-induced phosphatidylserine (PS) exposure on the platelet surface and microparticle
Nieswandt, B., Mattheij, Nadine, WÜLLING, M., Collins, Peter William, KÖHLER, R., Heemskerk, Johan, Cosemans, Judith, Cosemans, J. M., Castoldi, E., Heemskerk, J. W., KUNZELMANN, K., Cosemans, Judith; id_orcid, van Kruchten, Roger, Kuijpers, Marijke, Castoldi, Elisabetta, Baaten, C. J., van Kruchten, R., Kuijpers, M. J., PIRCHER, J., COLLINS, P.W., Mattheij, N. J., Braun, A., POOLE, A.W., Schreiber, R., VORTKAMP, A., Poole, A. W., Baaten, Constance   +26 more
core  

Dynamic modulation of auditory hair cell stereocilia membrane mechanics by the scrambling mechanotransduction complex

Summary Inner ear sensory hair cells convert mechanical deflection of their hair bundle into an electrical signal by gating novel mechanoelectrical transduction (MET) channels. Transmembrane channel-like proteins (TMCs) are a component of the MET machinery and part of a superfamily of molecules whose members are ion channels or lipid ...
Shefin S. George, Anthony J. Ricci
openaire   +1 more source

NINJ1 is activated by calcium-driven plasma membrane lipid scrambling during lytic cell death

Abstract NINJ1 is the terminal executioner of cellular rupture in multiple lytic cell death pathways through its clustering in the plasma membrane. Its activation trigger, however, remains unknown. We found that NINJ1-mediated plasma membrane rupture depends on calcium influx into the cell, which suffices to induce NINJ1-mediated ...
Jazlyn P. Borges, Yongqian Wang, Liron David, Allen Volchuk, Brunna Martins, Ruiqi Cai, Hao Wu, Spencer A. Freeman, Neil M. Goldenberg, Michael W. Salter, Benjamin E. Steinberg   +10 more
openaire   +1 more source

Upregulation of store operated Ca channel Orai1, stimulation of Ca(2+) entry and triggering of cell membrane scrambling in platelets by mineralocorticoid DOCA.

Kidney & blood pressure research, 2014
Mineralocorticoid excess leads to vascular injury, which is partially due to hypertension but in addition involves increased concentration of cytosolic Ca(2+) concentration in platelets, key players in the pathophysiology of occlusive vascular disease.
Guoxing, Liu, Guilai, Liu, Kousi, Alzoubi, Anja T, Umbach, Lisann, Pelzl, Oliver, Borst, Meinrad, Gawaz, Florian, Lang   +7 more
openaire   +1 more source

Calcium dependent activation of the TMEM16F scramblase and ion channel. [PDF]

Nat Struct Mol Biol
Feng Z, Alvarenga OE, Di Zanni E, Lee S, Khelashvili G, Accardi A.   +5 more
europepmc   +1 more source

TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience. [PDF]

Nat Commun
Lin Y, Zhou Z, Han Y, Cheng D, Wang HJ, Ju LA, Zhang Y, Cox CD, Corry B.   +8 more
europepmc   +1 more source

A pore is a pore is a pore (or a hub?): VDAC oligomerization in mitochondrial connectivity and modulation. [PDF]

Biochem Soc Trans
De Pinto V, Battiato G, Conti-Nibali S, Cubisino SAM.   +3 more
europepmc   +1 more source