Results 61 to 70 of about 4,109 (159)
Unraveling the Mysteries of Phospholipid Scrambling
, 2001 SummaryPlasma membrane phospholipid asymmetry is maintained by an aminophospholipid translocase that transports phosphatidylserine (PS) and phosphatidylethanolamine (PE) from outer to inner membrane leaflet.
Therese Wiedmer, Peter Sims
core +1 more source
Enhanced Eryptosis Following Exposure to Carnosic Acid
Cellular Physiology and Biochemistry, 2015 Background/Aims: The phenolic abietane diterpene component of rosemary and sage, carnosic acid, may either induce or inhibit apoptosis of nucleated cells.
Katja Stockinger +4 more
doaj +1 more source
Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397
Cellular Physiology and Biochemistry, 2016 Background/Aims: The CDC25B inhibitor NSC-95397 triggers apoptosis of tumor cells and is thus considered for the treatment of malignancy. The substance is effective in part by modification of gene expression.
Mohamed Jemaà +5 more
doaj +1 more source
Stimulation of Suicidal Erythrocyte Death by Phosphatase Inhibitor Calyculin A
Cellular Physiology and Biochemistry, 2016 Background/Aims: The serine/threonine protein phosphatase 1 and 2a inhibitor Calyculin A may trigger suicidal death or apoptosis of tumor cells. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal erythrocyte death ...
Mustafa Almasry +4 more
doaj +1 more source
Breakdown of Phosphatidylserine Asymmetry Following Treatment of Erythrocytes with Lumefantrine
Toxins, 2014 Background: Lumefantrine, a commonly used antimalarial drug, inhibits hemozoin formation in parasites. Several other antimalarial substances counteract parasitemia by triggering suicidal death or eryptosis of infected erythrocytes.
Kousi Alzoubi +5 more
doaj +1 more source
Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes
, 2009 This paper reviews the current knowledge on the various mechanisms for transbilayer, or flip-flop, lipid motion in model and cell membranes, enzyme-assisted lipid transfer by flippases, floppases and scramblases is briefly discussed, while non-catalyzed ...
Alonso, Alicia +7 more
core +1 more source
Stimulation of Eryptosis, the Suicidal Erythrocyte Death, by Costunolide
Cellular Physiology and Biochemistry, 2018 Background/Aims: The sesquiterpene lactone Costunolide is effective against various disorders including inflammation and malignancy. The substance is effective in part by triggering suicidal death or apoptosis of tumor cells.
Madeline Fink +3 more
doaj +1 more source
Triggering of Suicidal Erythrocyte Death by Ruxolitinib
Cellular Physiology and Biochemistry, 2015 Background/Aims: The JAK1/JAK2 tyrosine kinase inhibitor ruxolitinib is widely used for the treatment of myeloproliferative neoplasm-associated myelofibrosis and other malignancies. Most important side effects include anemia.
Marilena Briglia +5 more
doaj +1 more source
Stimulating Effect of Elvitegravir on Suicidal Erythrocyte Death
Cellular Physiology and Biochemistry, 2016 Background/Aims: The antiviral drug Elvitegravir is used for the treatment of Human Immunodeficiency Virus (HIV) infections. The present study explored whether the drug is able to trigger eryptosis, the suicidal death of erythrocytes.
Rosi Bissinger +3 more
doaj +1 more source
Characterization of the scrambling domain of the TMEM16 family
, 2017 Significance Plasma membrane in eukaryotic cells is composed of two layers, and phospholipids are asymmetrically distributed between them by an action of flippases.
Kenji Ishihara +4 more
core +1 more source