Diversity and Evolutionary Analysis of Venom Insulin Derived from Cone Snails [PDF]
ToxinsCone snails possess a diverse array of novel peptide toxins, which selectively target ion channels and receptors in the nervous and cardiovascular systems. These numerous novel peptide toxins are a valuable resource for future marine drug development. In
Qiqi Guo +6 more
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Non-Peptidic Small Molecule Components from Cone Snail Venoms [PDF]
Frontiers in Pharmacology, 2021 Venomous molluscs (Superfamily Conoidea) comprise a substantial fraction of tropical marine biodiversity (>15,000 species). Prior characterization of cone snail venoms established that bioactive venom components used to capture prey, defend against ...
Zhenjian Lin +14 more
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Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with In Vivo Zebrafish Larvae Assays [PDF]
ToxinsThis study presents nanofractionation analytics coupled with in vivo profiling of zebrafish embryo paralysis and lethality in response to toxins in cone snail venoms.
Jeroen Kool +6 more
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Fingerprint Analysis and Comparison of Activity Differences of Crude Venom from Five Species of Vermivorous Cone Snail in the South China Sea [PDF]
Marine DrugsThe South China Sea is rich in cone snail resources, known for producing conotoxins with diverse biological activities such as analgesic, anticancer, and insecticidal effects.
Shibo Sun +6 more
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Cysteine pattern barcoding-based dataset filtration enhances the machine learning-assisted interpretation of Conus venom peptide therapeutics. [PDF]
PLoS ONECrude cone snail venom is a rich source of bioactive compounds with significant therapeutic potential. In this study, we conducted a comprehensive analysis of 5,985 cone snail peptides across 82 Conus species to identify unique cysteine (Cys) patterns ...
Rimsha Bibi, Noshaba Qasmi, Sajid Rashid
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The Biological Role of Conoporins, Actinoporin-like Pore-Forming Toxins from Cone Snails [PDF]
ToxinsCone snails are a large group of marine gastropods that produce a complex mixture of toxic compounds to hunt prey and defend against predators. The majority of the venom comprises small toxic peptides named conotoxins, which target membrane receptors. In
Matija Ruparčič +5 more
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Predatory and Defensive Strategies in Cone Snails [PDF]
ToxinsCone snails are carnivorous marine animals that prey on fish (piscivorous), worms (vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly made of disulfide-rich conotoxins and conopeptides in a compartmentalized venom gland.
Zahrmina Ratibou +2 more
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Proteomic analysis of the venom of Conus flavidus from Red Sea reveals potential pharmacological applications [PDF]
Journal of Genetic Engineering and BiotechnologyBackground: Venomous marine cone snails produce unique neurotoxins called conopeptides or conotoxins, which are valuable for research and drug discovery.
Mousa O. Germoush +9 more
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In Silico Conotoxin Studies: Progress and Prospects [PDF]
MoleculesCone snails of the genus Conus have evolved to produce structurally distinct and functionally diverse venom peptides for defensive and predatory purposes.
Ruihan Li, Md. Mahadhi Hasan, Dan Wang
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Potential Ancestral Conoidean Toxins in the Venom Cocktail of the Carnivorous Snail Raphitoma purpurea (Montagu, 1803) (Neogastropoda: Raphitomidae) [PDF]
ToxinsVenomous marine gastropods of the superfamily Conoidea possess a rich arsenal of toxins, including neuroactive toxins. Venom adaptations might have played a fundamental role in the radiation of conoideans; nevertheless, there is still no knowledge about ...
Giacomo Chiappa +3 more
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