Results 11 to 20 of about 1,314 (159)

Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa [PDF]

Marine Drugs, 2019
The piscivorous cone snail Conus tulipa has evolved a net-hunting strategy, akin to the deadly Conus geographus, and is considered the second most dangerous cone snail to humans. Here, we present the first venomics study of C.
Mriga Dutt, Sébastien Dutertre, Ai-Hua Jin, Vincent Lavergne, Paul Francis Alewood, Richard James Lewis   +5 more
doaj   +4 more sources

Venom variation during prey capture by the cone snail, Conus textile. [PDF]

PLoS ONE, 2014
Observations of the mollusc-hunting cone snail Conus textile during feeding reveal that prey are often stung multiple times in succession. While studies on the venom peptides injected by fish-hunting cone snails have become common, these approaches have ...
Cecilia A Prator, Kellee M Murayama, Joseph R Schulz   +2 more
doaj   +4 more sources

Venom Diversity and Evolution in the Most Divergent Cone Snail Genus Profundiconus [PDF]

Toxins, 2019
Profundiconus is the most divergent cone snail genus and its unique phylogenetic position, sister to the rest of the family Conidae, makes it a key taxon for examining venom evolution and diversity. Venom gland and foot transcriptomes of Profundiconus cf.
Giulia Fassio, Maria Vittoria Modica, Lou Mary, Paul Zaharias, Alexander E. Fedosov, Juliette Gorson, Yuri I. Kantor, Mandё Holford, Nicolas Puillandre   +8 more
doaj   +6 more sources

Venomics-Accelerated Cone Snail Venom Peptide Discovery. [PDF]

Int J Mol Sci, 2018
Cone snail venoms are considered a treasure trove of bioactive peptides. Despite over 800 species of cone snails being known, each producing over 1000 venom peptides, only about 150 unique venom peptides are structurally and functionally characterized.
Himaya SWA, Lewis RJ.
europepmc   +5 more sources

Structures and interactions of insulin-like peptides from cone snail venom. [PDF]

Proteins, 2022
AbstractThe venomous insulin‐like peptides released by certain cone snails stimulate hypoglycemic shock to immobilize fish and catch the prey. Compared to human insulin (hIns), the cone snail insulins (Con‐Ins) are typically monomeric and shorter in sequence, yet they exhibit moderate hIns‐like biological activity.
Gorai B, Vashisth H.
europepmc   +4 more sources

Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. [PDF]

Protein Sci
Abstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Khilji MS, Hackney CM, Koch TL, Hone AJ, Rogalski A, Watkins M, Tun J, McIntosh JM, Olivera B, Safavi-Hemami H, Teilum K, Ellgaard L.   +11 more
europepmc   +2 more sources

Geographic Variation in Diet and Genetic Connectivity of Populations of the Widespread Predatory Cone Snail <i>Conus miliaris</i>. [PDF]

Ecol Evol
We examined patterns of dietary and genetic variation of a broadly distributed, Indo‐West Pacific cone snail at four sites in French Polynesia and compared them to populations at Guam, American Samoa, and Rapa Nui. Our results indicate that populations at French Polynesia possess broad and overlapping diets that are most similar to those of Rapa Nui ...
Duda TF, Vergara-Flórez DC.
europepmc   +2 more sources

Stenotrophomonas-Like Bacteria Are Widespread Symbionts in Cone Snail Venom Ducts. [PDF]

Appl Environ Microbiol, 2017
ABSTRACT Cone snails are biomedically important sources of peptide drugs, but it is not known whether snail-associated bacteria affect venom chemistry. To begin to answer this question, we performed 16S rRNA gene amplicon sequencing of eight cone snail species, comparing their microbiomes with each other and with those from a ...
Torres JP, Tianero MD, Robes JMD, Kwan JC, Biggs JS, Concepcion GP, Olivera BM, Haygood MG, Schmidt EW.   +8 more
europepmc   +4 more sources

Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. [PDF]

Mol Cell Proteomics, 2013
Cone snails produce highly complex venom comprising mostly small biologically active peptides known as conotoxins or conopeptides. Early estimates that suggested 50-200 venom peptides are produced per species have been recently increased at least 10-fold using advanced mass spectrometry.
Dutertre S, Jin AH, Kaas Q, Jones A, Alewood PF, Lewis RJ.   +5 more
europepmc   +4 more sources

Combined Proteotranscriptomic-Based Strategy to Discover Novel Antimicrobial Peptides from Cone Snails

Biomedicines, 2021
Despite their impressive diversity and already broad therapeutic applications, cone snail venoms have received less attention as a natural source in the investigation of antimicrobial peptides than other venomous animals such as scorpions, spiders, or ...
Anicet Ebou, Dominique Koua, Audrey Addablah, Solange Kakou-Ngazoa, Sébastien Dutertre   +4 more
doaj   +1 more source