Results 21 to 30 of about 1,314 (159)

Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans

Toxins, 2022
The defensive use of cone snail venom is hypothesised to have first arisen in ancestral worm-hunting snails and later repurposed in a compartmentalised venom duct to facilitate the dietary shift to molluscivory and piscivory.
Jutty Rajan Prashanth, Sebastien Dutertre, Subash Kumar Rai, Richard J. Lewis   +3 more
doaj   +1 more source

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain. [PDF]

JOR Spine
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
Melrose J, Sima S, Chopra N, Diwan A, Gu Z.   +4 more
europepmc   +2 more sources

A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail Cylinder ammiralis (Caenogastropoda: Conidae)

Toxins, 2021
Venoms are complex mixtures of proteins that have evolved repeatedly in the animal kingdom. Cone snail venoms represent one of the best studied venom systems.
Samuel Abalde, Sébastien Dutertre, Rafael Zardoya   +2 more
doaj   +1 more source

Prey Shifts Drive Venom Evolution in Cone Snails. [PDF]

Mol Biol Evol
Abstract Venom systems are complex traits that have independently emerged multiple times in diverse plant and animal phyla. Within each venomous lineage there typically exists interspecific variation in venom composition where several factors have been proposed as drivers of variation, including phylogeny and diet.
Koch TL, Robinson SD, Salcedo PF, Chase K, Biggs J, Fedosov AE, Yandell M, Olivera BM, Safavi-Hemami H.   +8 more
europepmc   +6 more sources

Microhabitats within Venomous Cone Snails Contain Diverse Actinobacteria [PDF]

Applied and Environmental Microbiology, 2009
ABSTRACT Actinomycetes can be symbionts in diverse organisms, including both plants and animals. Some actinomycetes benefit their host by producing small molecule secondary metabolites; the resulting symbioses are often developmentally complex. Actinomycetes associated with three cone snails were studied.
Olivier, Peraud, Jason S, Biggs, Ronald W, Hughen, Alan R, Light, Gisela P, Concepcion, Baldomero M, Olivera, Eric W, Schmidt   +6 more
openaire   +2 more sources

Conodipine-P1-3, the First Phospholipases A₂ Characterized from Injected Cone Snail Venom. [PDF]

Mol Cell Proteomics, 2019
The phospholipase A2 (PLA2s) superfamily are ubiquitous small enzymes that catalyze the hydrolysis of phospholipids at the sn-2 ester bond. PLA2s in the venom of cone snails (conodipines, Cdpi) are composed of two chains termed as alpha and beta subunits. Conodipines are categorized within the group IX of PLA2s.
Möller C, Davis WC, Clark E, DeCaprio A, Marí F.   +4 more
europepmc   +3 more sources

Coral Venom and Toxins as Protection Against Crown-of-Thorns Sea Star Attack. [PDF]

Mol Ecol
ABSTRACT Crown‐of‐thorns sea star (CoTS) outbreaks are a main cause of hard coral cover decline across the Indo‐Pacific, posing a major threat to the resilience of coral reefs. However, the drivers underlying CoTS feeding on preferred (e.g., Acropora species) versus non‐preferred (e.g., Porites species) are poorly understood. We hypothesised that coral
Gorman LM, Huffmyer AS, Byrne M, Mills SC, Putnam HM.   +4 more
europepmc   +2 more sources

Recruitment of Glycosyl Hydrolase Proteins in a Cone Snail Venomous Arsenal: Further Insights into Biomolecular Features of Conus Venoms

Marine Drugs, 2012
Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities.
Philippe Favreau, Igor Križaj, Frédéric Ducancel, Reto Stöcklin, Florian Noguier, Sébastien Dutertre, Daniel Biass, David Piquemal, Yves Terrat, Adrijana Leonardi, Aude Violette   +10 more
doaj   +1 more source

Cone snail species off the Brazilian coast and their venoms: a review and update

Journal of Venomous Animals and Toxins including Tropical Diseases, 2023
The genus Conus includes over 900 species of marine invertebrates known as cone snails, whose venoms are among the most powerful described so far.
Helena B. Fiorotti, Suely G. Figueiredo, Fabiana V. Campos, Daniel C. Pimenta   +3 more
doaj   +1 more source

Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background: Diverse and unique bioactive neurotoxins known as conopeptides or conotoxins are produced by venomous marine cone snails. Currently, these small and stable molecules are of great importance as research tools and platforms for discovering new ...
Maged M. A. Fouda, Mohammed Abdel-Wahab, Amal Mohammadien, Mousa O. Germoush, Moustafa Sarhan   +4 more
doaj   +1 more source