Results 31 to 40 of about 1,314 (159)

An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs. [PDF]

FASEB J
α‐RoIA is an atypical N‐terminally elongated conotoxin discovered in Conus rolani. N‐terminal elongation delays activity in vivo; however, this elongation must be removed to block muscle nicotinic acetylcholine receptors (nAChRs). Only the truncated ribbon isoform of RoIA blocks muscle nAChRs.
Giglio ML, Flórez-Salcedo P, Azam L, Watkins M, Koch TL, Basgall-De la Rosa E, Douglass AD, McIntosh JM, Olivera BM, Gajewiak J.   +9 more
europepmc   +2 more sources

Hormone-like peptides in the venoms of marine cone snails [PDF]

General and Comparative Endocrinology, 2017
The venoms of cone snails (genus Conus) are remarkably complex, consisting of hundreds of typically short, disulfide-rich peptides termed conotoxins. These peptides have diverse pharmacological targets, with injection of venom eliciting a range of physiological responses, including sedation, paralysis and sensory overload.
Robinson, Samuel D., Li, Qing, Bandyopadhyay, Pradip K., Gajewiak, Joanna, Yandell, Mark, Papenfuss, Anthony T., Purcell, Anthony W., Norton, Raymond S., Safavi-Hemami, Helena   +8 more
openaire   +3 more sources

The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

Marine Drugs, 2017
The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world.
Samuel D. Robinson, Qing Li, Aiping Lu, Pradip K. Bandyopadhyay, Mark Yandell, Baldomero M. Olivera, Helena Safavi-Hemami   +6 more
doaj   +1 more source

Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa [PDF]

Molecular Biology and Evolution, 2016
A specialized insulin was recently found in the venom of a fish-hunting cone snail, Conus geographus Here we show that many worm-hunting and snail-hunting cones also express venom insulins, and that this novel gene family has diversified explosively.
Safavi-Hemami, Helena, Lu, Aiping, Li, Qing, Fedosov, Alexander E., Biggs, Jason, Corneli, Patrice Showers, Seger, Jon, Yandell, Mark, Olivera, Baldomero M.   +8 more
openaire   +4 more sources

The Mitochondrial Genome of the Venomous Cone Snail Conus consors

PLoS ONE, 2012
Cone snails are venomous predatory marine neogastropods that belong to the species-rich superfamily of the Conoidea. So far, the mitochondrial genomes of two cone snail species (Conus textile and Conus borgesi) have been described, and these feed on snails and worms, respectively.
Brauer, Age, Kurz, Alexander, Stockwell, Tim, Baden-Tillson, Holly, Heidler, Juliana, Wittig, Ilka, Kauferstein, Silke, Mebs, Dietrich, Stöcklin, Reto, Remm, Maido   +9 more
openaire   +6 more sources

Dietary breadth is positively correlated with venom complexity in cone snails [PDF]

BMC Genomics, 2015
AbstractAlthough diet is believed to be a major factor underlying the evolution of venom, few comparative studies examine both venom composition and diet across a radiation of venomous species. Cone snails within the family, Conidae, comprise more than 700 species of carnivorous marine snails that capture their prey by using a cocktail of venomous ...
Phuong, Mark A, Mahardika, Gusti N, Alfaro, Michael E   +2 more
openaire   +4 more sources

From DNA enzymes to cone snail venom: the work of Baldomero M. Olivera. [PDF]

J Biol Chem, 2012
Processivity of DNA Exonucleases (Thomas, K. R., and Olivera, B. M. (1978) J. Biol. Chem. 253, 424–429 )Neuronal Calcium Channel Inhibitors. Synthesis of ω-Conotoxin GVIA and Effects on 45Ca Uptake by Synaptosomes (Rivier, J., Galyean, R., Gray, W. R., Azimi-Zonooz, A., McIntosh, J. M., Cruz, L. J., and Olivera, B. M. (1987) J. Biol. Chem.
Mukhopadhya R.
europepmc   +4 more sources

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

eLife, 2019
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin ...
Peter Ahorukomeye, Maria M Disotuar, Joanna Gajewiak, Santhosh Karanth, Maren Watkins, Samuel D Robinson, Paula Flórez Salcedo, Nicholas A Smith, Brian J Smith, Amnon Schlegel, Briony E Forbes, Baldomero Olivera, Danny Hung-Chieh Chou, Helena Safavi-Hemami   +13 more
doaj   +1 more source

High-throughput prediction and characterization of antimicrobial peptides from multi-omics datasets of Chinese tubular cone snail (Conus betulinus)

Frontiers in Marine Science, 2022
Individual cone snail (Conus sp.) contains thousands of bioactive peptides, but there are limited studies on its antimicrobial peptides (AMPs). Here, we investigated AMPs along with AMP-derived genes in the representative Chinese tubular cone snail (C ...
Ruihan Li, Ruihan Li, Yu Huang, Chao Peng, Zijian Gao, Jie Liu, Xiaoting Yin, Xiaoting Yin, Xiaoting Yin, Bingmiao Gao, Tatiana V. Ovchinnikova, Limei Qiu, Limei Qiu, Chao Bian, Chao Bian, Qiong Shi, Qiong Shi   +16 more
doaj   +1 more source

Toxinology of Marine Venomous Snails

Iranian South Medical Journal, 2021
A surprisingly large number of sea snail species are venomous. Cone snail venoms are produced in a lengthy tubular duct from a complex venom gland and form a cocktail of many toxins, particularly conotoxins which have high potency and specificity for ...
Gholam Hossein Mohebbi, Iraj Nabipour
doaj