Results 41 to 50 of about 1,314 (159)

In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds

Journal of Venomous Animals and Toxins including Tropical Diseases, 2016
During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey.
Eline K. M. Lebbe, Jan Tytgat
doaj   +1 more source

Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct

BMC Genomics, 2012
Background The fish-hunting cone snail, Conus geographus, is the deadliest snail on earth. In the absence of medical intervention, 70% of human stinging cases are fatal.
Hu Hao, Bandyopadhyay Pradip K, Olivera Baldomero M, Yandell Mark   +3 more
doaj   +1 more source

Cone snail milked venom dynamics – A quantitative study of Conus purpurascens [PDF]

Toxicon, 2012
Milked venom from cone snails represent a novel biological resource with a proven track record for drug discovery. To strengthen this correlation, we undertook a chromatographic and mass spectrometric study of individual milked venoms from Conus purpurascens.
Joycelyn B S, Chun, Margaret R, Baker, Do H, Kim, Majdouline, Leroy, Priamo, Toribo, Jon-Paul, Bingham   +5 more
openaire   +2 more sources

Discovery Methodology of Novel Conotoxins from Conus Species

Marine Drugs, 2018
Cone snail venoms provide an ideal resource for neuropharmacological tools and drug candidates discovery, which have become a research hotspot in neuroscience and new drug development. More than 1,000,000 natural peptides are produced by cone snails, but
Ying Fu, Cheng Li, Shuai Dong, Yong Wu, Dongting Zhangsun, Sulan Luo   +5 more
doaj   +1 more source

Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from Conus miliaris

Marine Drugs, 2020
Cone snails produce a fast-acting and often paralyzing venom, largely dominated by disulfide-rich conotoxins targeting ion channels. Although disulfide-poor conopeptides are usually minor components of cone snail venoms, their ability to target key ...
Julien Giribaldi, Lotten Ragnarsson, Tom Pujante, Christine Enjalbal, David Wilson, Norelle L. Daly, Richard J. Lewis, Sebastien Dutertre   +7 more
doaj   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Organic Electrochemical Transistors for Neuromorphic Devices and Applications

Advanced Materials, Volume 38, Issue 9, 12 February 2026.
Organic electrochemical transistors are emerging as promising platforms for neuromorphic devices that emulate neuronal and synaptic activities and can seamlessly integrate with biological systems. This review focuses on resultant organic artificial neurons, synapses, and integrated devices, with an emphasis on their ability to perform neuromorphic ...
Kexin Xiang, Jiajun Song, Hong Liu, Junxin Chen, Feng Yan   +4 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

The introduction of marine cone snail species from the coast of the Qeshm Island, contains conotoxin palliative pain in mice [PDF]

بوم‌شناسی آبزیان, 2019
Conotoxins are small toxic peptides that are synthesized in cone snail venom ducts. Conotoxins have analgesic effects in models animal. In this study, the analgesic effects with no toxicity of Persian Gulf cone snails, Conus coronatus, and Conus frigidus
Halimeh Rajabi, Hossein Zolgharnen, Mohammad Taghi Ronagh, Ahmad Savari, Mohammad Sharif Ranjbar   +4 more
doaj  

High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development

BioDesign Research, 2022
Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to their pharmacological applications in development of marine drugs for treatment of various human diseases.
Bingmiao Gao, Yu Huang, Chao Peng, Bo Lin, Yanling Liao, Chao Bian, Jiaan Yang, Qiong Shi   +7 more
doaj   +1 more source