Results 71 to 80 of about 1,314 (159)
Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails
Marine Drugs, 2018 Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
doaj +1 more source
Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae. [PDF]
PLoS ONE, 2014 Animal venoms represent a vast library of bioactive peptides and proteins with proven potential, not only as research tools but also as drug leads and therapeutics.
Samuel D Robinson +5 more
doaj +1 more source
Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways [PDF]
Journal of Proteomics, 2019 There have been numerous attempts to develop non-opioid drugs for severe pain, but the vast majority of these efforts have failed. A notable exception is Ziconotide (Prialt®), approved by the FDA in 2004. In this review, we summarize the present status of Ziconotide as a therapeutic drug and introduce a wider framework: the potential of venom peptides ...
Helena, Safavi-Hemami +2 more
openaire +2 more sources
Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
Marine Drugs, 2014 Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom.
Eline K. M. Lebbe +3 more
doaj +1 more source
Biomedicines, 2020 Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous measurable scientific and societal benefits.
Walden E. Bjørn-Yoshimoto +6 more
doaj +1 more source
Analysis of a cone snail's killer cocktail – The milked venom of Conus geographus [PDF]
Toxicon, 2012 "Snails can kill" is a statement that receives much disbelief. Yet the venom from Conus geographus, as delivered by a disposable hypodermic-like needle, has indeed killed many unsuspecting human victims. Our understanding of their milked venom the essence of these fatalities, is in itself non-existent.
Jon-Paul, Bingham +2 more
openaire +2 more sources
Exploring Use of a Protein Cage System for Producing Bioactive Peptides in Escherichia coli
Microbial Biotechnology, Volume 18, Issue 6, June 2025.Bioactive peptides can be difficult to manufacture biosynthetically. This study explored the use of bacteriophage P22 virus‐like particles to encapsulate recombinantly expressed bioactive peptides, enabling the production of therapeutically valuable linear and cyclic peptides in Escherichia coli.
Maxim D. Harding +6 more
wiley +1 more source
Marine Drugs, 2019 Conus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species.
Jorge L. B. Neves +10 more
doaj +1 more source
FEBS Open Bio, Volume 15, Issue 3, Page 415-426, March 2025.Sea stars have remarkable regenerative capabilities. A peptide, KASH2, identified in the biofluid of the common sea star Asterias rubens appears to be involved with the wound‐healing response in the organism. Here, we show the 3D structure of KASH2 adopts a disulfide‐directed β‐hairpin fold, a fold only previously found in arachnids, and does not show ...
Rozita Takjoo +10 more
wiley +1 more source
Enabling Access to Novel Bacterial Biosynthetic Potential From ONT Draft Genomic Data
Microbial Biotechnology, Volume 18, Issue 3, March 2025.We demonstrated that a draft genome assembly obtained using long‐read sequencing is enough for the bioprospection of BGCs, and that it allowed us to successfully clone a novel lanthipeptide BGC into a genome engineering‐ready vector, illustrating the capabilities of this strategy for the discovery of novel natural products.
Marco A. Campos‐Magaña +2 more
wiley +1 more source