Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis
Frontiers in Immunology, 2022 Dendritic cells (DC) play critical roles in linking innate and adaptive immunity. DC are heterogenous and there are subsets with various distinct functions.
Izumi Sasaki +7 more
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Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses [PDF]
Frontiers in Immunology, 2019 Dendritic cells (DCs) facilitate cross talk between the innate and adaptive immune system. They sense and phagocytose invading pathogens, and are not only capable of activating naïve T cells, but can also determine the polarization of T cell responses ...
Demo Yemane Tesfaye +8 more
doaj +5 more sources
Conventional type 1 dendritic cells (cDC1) in cancer immunity
Biology Direct, 2023 Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses.
Peng Liu +3 more
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Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo [PDF]
Frontiers in Immunology, 2018 Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Johanna Salvermoser +15 more
doaj +6 more sources
Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells [PDF]
Pharmaceutics, 2020 Throughout the last decades, dendritic cell (DC)-based anti-tumor vaccines have proven to be a safe therapeutic approach, although with inconsistent clinical results. The functional limitations of ex vivo monocyte-derived dendritic cells (MoDCs) commonly
João Calmeiro +7 more
doaj +4 more sources
STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation [PDF]
iScience, 2020 Summary: Signaling through stimulator of interferon genes (STING) leads to the production of type I interferons (IFN-Is) and inflammatory cytokines. A gain-of-function mutation in STING was identified in an autoinflammatory disease (STING-associated ...
Arthid Thim-uam +11 more
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Regulatory T cells diminish transmission of HIV from Dendritic cells to conventional CD4+ T cells [PDF]
Frontiers in Immunology, 2014 Formation of immunological synapses between dendritic cells (DC) and conventional CD4+ T cells (Tcon) is critical for productive immune responses. However, when DCs are HIV-infected such synapses are critical to establish HIV infection.
Maria Eugenia Moreno-Fernandez +3 more
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Development of Pig Conventional Dendritic Cells From Bone Marrow Hematopoietic Cells in vitro [PDF]
Frontiers in Immunology, 2020 In recent years, porcine dendritic cells (DCs) have been identified from pig tissues. However, studying the interaction of porcine DCs with pathogens is still difficult due to the scarcity of DCs in tissues.
Yanli Li +5 more
doaj +4 more sources
mTORC2 Deficiency Alters the Metabolic Profile of Conventional Dendritic Cells [PDF]
Frontiers in Immunology, 2019 In myeloid dendritic cells (DC), deletion of the mechanistic target of rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, the underlying mechanism has not been resolved.
Alicia R. Watson +13 more
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RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells [PDF]
Nature Communications, 2018 Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin.
Seika Hashimoto-Hill +5 more
doaj +3 more sources