Results 21 to 30 of about 115,545 (228)
Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity [PDF]
The Journal of Immunology, 2020 Abstract Conventional dendritic cells (cDCs) are arguably the most potent APCs that induce the activation of naive T cells in response to pathogens. In addition, at steady-state, cDCs help maintain immune tolerance. Two subsets of cDCs have been extensively characterized, namely cDC1 and cDC2, each contributing differently to immune ...
Cindy Audiger +5 more
openaire +2 more sources
Usp18 Promotes Conventional CD11b+ Dendritic Cell Development [PDF]
The Journal of Immunology, 2012 Abstract Dendritic cells (DCs) represent the key cells linking innate and adaptive immune responses. It is critical to understand the molecular factors regulating DC differentiation. Usp18 is an IFN-inducible member of the ubiquitin-specific protease family, which deconjugates ubiquitin-like modifier ISG15 from target proteins and ...
Xiu-Li, Cong +5 more
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Conventional Dendritic Cells Impair Recovery after Myocardial Infarction [PDF]
The Journal of Immunology, 2018 Abstract Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to pathogenesis of specific cardiac mononuclear phagocyte lineages, in particular ...
Jun Seong Lee +17 more
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Cutting Edge: B220+CCR9− Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells [PDF]
The Journal of Immunology, 2009 Abstract Mouse lymphoid organs contain two major subsets of dendritic cells (DC) that differ in their phenotype and functions: conventional DC (cDC) and plasmacytoid DC (pDC). Recently, it has been proposed that differential expression of CCR9 could distinguish functionally distinct pDC subsets.
Elodie, Segura +2 more
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Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells [PDF]
Blood, 2012 AbstractDendritic cell (DC) homeostasis in peripheral tissues reflect a balance between DC generation, migration, and death. The current model of DC ontogeny indicates that pre-cDCs are committed to become terminal conventional DCs (cDCs). Here, we report the unexpected finding that proliferating immunostimulatory CD11c+ MHC class II+ cDCs derived from
Jun, Diao +5 more
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Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation [PDF]
The Journal of Immunology, 2016 Abstract Monocyte-derived dendritic cells (moDCs) dramatically increase in numbers upon infection and inflammation; accordingly, we found that this also occurs during allogeneic responses. Despite their prominence, how emergent moDCs and resident conventional DCs (cDCs) divide their labor as APCs remain undefined.
Kevin V Chow +3 more
openaire +2 more sources
The clinical application of cancer immunotherapy based on naturally circulating dendritic cells
Journal for ImmunoTherapy of Cancer, 2019 Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administered into the patient with the aim to induce a ...
Kalijn F. Bol +13 more
doaj +1 more source
Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]
PLoS ONE, 2013 Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda +9 more
doaj +1 more source
CD14 Expressing Precursors Give Rise to Highly Functional Conventional Dendritic Cells for Use as Dendritic Cell Vaccine. [PDF]
Cancers (Basel), 2021 Induction of long-lasting immunity by dendritic cells (DCs) makes them attractive candidates for anti-tumor vaccination. Although DC vaccinations are generally considered safe, clinical responses remain inconsistent in clinical trials. This initiated studies to identify subsets of DCs with superior capabilities to induce effective and memory anti-tumor
Plantinga M +3 more
europepmc +5 more sources
Frontiers in Immunology, 2019 Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. The effects of DCs on adaptive immune responses depend partly on functional specialization of distinct DC subsets, and partly on the activation state of DCs, which is ...
Claudia Carenza +13 more
doaj +1 more source