Results 71 to 80 of about 115,545 (228)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Reprogramming Tumor Cell Death via Processing Natural Drug to Carbon Dots Overcomes Collagen Barrier and Activates Antitumor Immunity

Advanced Functional Materials, EarlyView.
A traditional Chinese medicine‐derived carbon dots nanoplatform reprograms tumor cell death from apoptosis to necroptosis, dismantling therapy‐induced collagen barriers and promoting immunogenic death. pH‐responsive hydrogel assembled from carbon dots for localized delivery, this strategy suppresses primary tumors and metastasis, offering a new ...
Zekun Yan, Hongwei Cheng, Yupeng Liu, Wenfeng Xu, Quansheng Cheng, Lingyun Li, Xue Wu, Yingqi Liang, Jing Zhao, Gang Liu, Shaoping Li, Songnan Qu   +11 more
wiley   +1 more source

Gram‐Scale Production of Iron Oxide Rubik‐Cube Nanoparticles: New Tools for the Clinical Translation of Magnetic Hyperthermia and Magnetic Particle Imaging

Advanced Functional Materials, EarlyView.
This work reports the first gram‐scale solvothermal synthesis of ‘Rubik's cube’ nanoparticles—cubic, dendritic multicore structures with tuneable sizes and exceptional magnetic heating performance. Featuring iron oxide single‐domain character, with low coercivity fields, high magnetization, and strong MPI signals, they enable viscosity‐independent ...
Giusy M. R. Rizzo, Niccolò Silvestri, Nabila Jarmouni, Helena Gavilán, Hamza Yakubu, Daniel Arenas‐Esteban, Sara Bals, Paola Parlanti, Mauro Gemmi, Ross Clark Prado, Anna Cristina S. Samia, Verónica Salgueiriño, Teresa Pellegrino   +12 more
wiley   +1 more source

A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs

Nature Communications
While CD4+ T cells are a prerequisite for CD8+ T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to intrahepatic CD8+ T cells are unknown.
Kieran English, Rain Kwan, Lauren E. Holz, Claire McGuffog, Jelte M. M. Krol, Daryan Kempe, Tsuneyasu Kaisho, William R. Heath, Leszek Lisowski, Maté Biro, Geoffrey W. McCaughan, David G. Bowen, Patrick Bertolino   +12 more
doaj   +1 more source

Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells

Cell Reports
Plasmacytoid dendritic cells (pDCs) play a pivotal role in immune responses, particularly against viral infections. pDCs exhibit diverse functions, including interferon production, cytokine secretion, and antigen presentation. Here, we investigate the antigen cross-presentation capacity of pDCs and their role in CD8+ T cell activation.
Renée M. van der Sluis, Juan L. García-Rodríguez, Ian Helstrup Nielsen, Albert Gris-Oliver, Jennifer Becker, Bibiana Costa, M. Zeeshan Chaudhry, Marvin Werner, Anders Laustsen, Jesper G. Pedersen, Kristine R. Gammelgaard, Trine H. Mogensen, Ulrich Kalinke, Luka Cicin-Sain, Rasmus O. Bak, Lasse S. Kristensen, Martin R. Jakobsen   +16 more
openaire   +2 more sources

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells [PDF]

Proceedings of the National Academy of Sciences, 2007
We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved,
Kazumichi, Abe, Kim Phung, Nguyen, Sean D, Fine, Ji-Hun, Mo, Carol, Shen, Steve, Shenouda, Maripat, Corr, Steffen, Jung, Jongdae, Lee, Lars, Eckmann, Eyal, Raz   +10 more
openaire   +2 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

eLife, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent infection. With advancing age the GC and Tfh cell response declines, resulting in impaired humoral immunity.
Stebegg, Marisa, Bignon, Alexandre, Hill, Danika Lea, Silva-Cayetano, Alyssa, Krueger, Christel, Vanderleyden, Ine, Innocentin, Silvia, Boon, Louis, Wang, Jiong, Zand, Martin S., Dooley, James, Clark, Jonathan, Liston, Adrian, Carr, Edward, Linterman, Michelle A.   +14 more
openaire   +5 more sources

Block Copolymers: Emerging Building Blocks for Additive Manufacturing

Advanced Functional Materials, EarlyView.
This review addresses how block copolymer (BCP) physics and rheology have led to the widespread use of BCPs in advanced additive manufacturing techniques, with particular emphasis on the untapped potential of these nanostructured materials toward achieving multi‐scale architected materials with unique, programmable material properties.
Alice S. Fergerson, Hemish B. Thakkar, Jiaen Wu, Emily C. Davidson   +3 more
wiley   +1 more source

Localized High‐Concentration Electrolyte with Water‐Miscible Diluent Enables Stable Zinc Deposition and Long‐Life Aqueous Zinc Metal Batteries

Advanced Functional Materials, EarlyView.
A diisopropyl ether (DIPE)‐based, localized, high‐concentration electrolyte is developed to stabilize both electrodes in aqueous zinc batteries. By reducing water activity and promoting anion‐rich zinc‐ion solvation, it builds robust interphases at both the cathode and anode, ensuring uniform deposition, suppressed corrosion, and highly reversible ...
Yuxuan Wu, Ziwei Zhao, Yue Fei, Hao Zhang, Ge Li   +4 more
wiley   +1 more source