Results 1 to 10 of about 58,930 (131)

Role of Damage-Associated Molecular Patterns (DAMPs/Alarmins) in Severe Ocular Allergic Diseases [PDF]

Cells, 2022
Severe ocular allergic diseases, such as atopic keratoconjunctivitis and vernal keratoconjunctivitis, cause severe allergic inflammation in the conjunctiva and corneal epithelial damage, resulting in visual disturbances. The involvement of damage (danger)
Ken Fukuda, Waka Ishida, Tatsuma Kishimoto, Isana Nakajima, Yusaku Miura, Tamaki Sumi, Kenji Yamashiro   +6 more
doaj   +2 more sources

Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy [PDF]

Molecular Biomedicine
Damage-associated molecular patterns (DAMPs) are endogenous danger signal molecules released by damaged, stressed or dead cells that bind to pattern recognition receptors (PRRs), activating immune responses and inflammatory signaling pathways to play ...
Heya Lin, Wei Xiong, Lili Fu, Jie Yi, Jiantang Yang   +4 more
doaj   +2 more sources

Untangling Local Pro-Inflammatory, Reparative, and Regulatory Damage-Associated Molecular-Patterns (DAMPs) Pathways to Improve Transplant Outcomes [PDF]

Frontiers in Immunology, 2021
Detrimental inflammatory responses after solid organ transplantation are initiated when immune cells sense pathogen-associated molecular patterns (PAMPs) and certain damage-associated molecular patterns (DAMPs) released or exposed during transplant ...
Gaelen K. Dwyer, Gaelen K. Dwyer, Hēth R. Turnquist, Hēth R. Turnquist, Hēth R. Turnquist   +4 more
doaj   +2 more sources

From stress signals to fertility challenges: the role of damage-associated molecular patterns in male reproduction [PDF]

Frontiers in Immunology
Male infertility is influenced by genetic abnormalities, hormonal imbalances, lifestyle factors, and environmental exposures. Recently, Damage-Associated Molecular Patterns (DAMPs) have emerged as key players in male reproductive health, particularly in ...
Heran Cao, Heran Cao, Shujuan Liu, Shichao Cui, Shichao Cui, Hua Nie, Hua Nie, Xiaohua Liu, Xiaohua Liu, Weibing Qin, Weibing Qin   +10 more
doaj   +2 more sources

The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases : Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine [PDF]

Sultan Qaboos University Medical Journal, 2015
This article is the second part of a review that addresses the role of damage-associated molecular patterns (DAMPs) in human diseases by presenting examples of traumatic (systemic inflammatory response syndrome), cardiovascular (myocardial infarction ...
Walter G. Land
doaj   +3 more sources

Damage-associated molecular patterns in vitiligo: igniter fuse from oxidative stress to melanocyte loss

Redox Report, 2022
Objectives The pathogenesis of vitiligo remains unclear. In this review, we comprehensively describe the role of damage associated molecular patterns (DAMPs) during vitiligo pathogenesis.Methods Published papers on vitiligo, oxidative stress and DAMPs ...
Jingying Wang, Yinghao Pan, Guangmin Wei, Hanxiao Mao, Rulan Liu, Yuanmin He   +5 more
doaj   +1 more source

Role of Damage-Associated Molecular Pattern/Cell Death Pathways in Vaccine-Induced Immunity

Viruses, 2021
Immune responses induced by natural infection and vaccination are known to be initiated by the recognition of microbial patterns by cognate receptors, since microbes and most vaccine components contain pathogen-associated molecular patterns.
Sun Min Lee, Paul Kim, Jinsuh You, Eui Ho Kim   +3 more
doaj   +1 more source

Danger signals in traumatic hemorrhagic shock and new lines for clinical applications

Frontiers in Physiology, 2023
Hemorrhage is the leading cause of death in severe trauma injuries. When organs or tissues are subjected to prolonged hypoxia, danger signals—known as damage-associated molecular patterns (DAMPs)—are released into the intercellular environment.
Frédérique Dufour-Gaume, Nadira Frescaline, Venetia Cardona, Nicolas J. Prat   +3 more
doaj   +1 more source

Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

Rheumatology & Autoimmunity, 2022
All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs).
Na Kang, Xiaohang Liu, Kabeer Haneef, Wanli Liu   +3 more
doaj   +1 more source

AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke

Cell Reports, 2021
Summary: The sterile inflammation caused by damage-associated molecular patterns (DAMPs) worsens the prognosis following primary injury such as ischemic stroke. However, there are no effective treatments to regulate DAMPs.
Natsumi Maehara, Kaori Taniguchi, Ami Okuno, Hideaki Ando, Aika Hirota, Zhiheng Li, Ching-Ting Wang, Satoko Arai, Toru Miyazaki   +8 more
doaj   +1 more source