Diosmetin Inhibits NETs Formation in Neutrophils Through Regulating Nrf2 Signaling [PDF]
Thoracic CancerBackground Neutrophil extracellular traps (NETs) are important pieces of equipment for neutrophils. Excess NETs play promoting roles in cancer‐associated thrombosis (CAT).
Lijuan Guo +18 more
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Discover OncologyProstate cancer is a prevalent and highly heterogeneous malignancy that affects men globally. Despite the availability of various treatment targets, Cytochrome P450 (CYP) enzymes have gained significant attention due to their crucial role in metabolizing
Mohammad Habibur Rahman Molla +1 more
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Antihypertensive Effects of Diosmetin in Hypertension-Induced Cardiovascular Abnormalities in Rats [PDF]
Journal of Experimental PharmacologyBanyaphon Jan-O,1 Metee Iampanichakul,1 Prapassorn Potue,1 Juthamas Khamseekaew,1 Poungrat Pakdeechote,1 Piman Pocasap,2 Parichat Prachaney,3 Anuson Poasakate,4 Putcharawipa Maneesai1 1Department of Physiology, Faculty of Medicine, Khon Kaen University ...
Jan-O B +8 more
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Dunaliella salina-Loaded Diosmetin Carriers Alleviate Oxidative Stress and Inflammation in Cisplatin-Induced Acute Kidney Injury via PI3K/AKT Pathway [PDF]
PharmaceuticsBackground: As a widely used chemotherapeutic agent, cisplatin frequently induces acute kidney injury (AKI), which severely compromises patient survival and limits its clinical use.
Yujing Huangfu +9 more
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Synergistic combinatorial anticancer potential of Tamoxifen with Naringin and Diosmetin in MCF-7 breast cancer cells and their liposomal delivery [PDF]
Scientific ReportsBreast cancer continues to remain a significant issue due to resistance to endocrine therapies, including tamoxifen. Naringin and Diosmetin (natural flavonoids) have anticancer effects that may synergistically enhance therapeutic efficacy when used with ...
Priyanka Uniyal +9 more
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Tailored biosynthesis of diosmin through reconstitution of the flavonoid pathway in Nicotiana benthamiana [PDF]
Frontiers in Plant ScienceThe flavonoid diosmin (diosmetin 7-O-rutinoside) is used as a therapeutic agent for disorders of the blood vessels such as hemorrhoids and varicose veins. Diosmin is commercially produced using semi-synthetic methods involving the oxidation of hesperidin,
Hyo Lee +5 more
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Targeting INF2 with DiosMetin 7-O-β-D-Glucuronide: a new stratagem for colorectal cancer therapy [PDF]
BMC CancerBackground and purpose Colorectal cancer (CRC) is the third most prevalent malignancy in the gastrointestinal tract and the second leading cause of cancer-related deaths.
Zhirui Zeng +8 more
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Comprehensive Analysis of Sulfated Flavonoids in Eclipta prostrata for Quality Evaluation [PDF]
MoleculesEclipta prostrata (Asteraceae) is employed as a hemostatic agent in many traditional medicines, owing to its sulfated flavonoid content. In this study, we obtained crude drug samples from three provinces collected in different years and analyzed their ...
Ryunosuke Sato +2 more
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Pharmaceuticals, 2022 Objective: Diosmetin is a flavonoid that is found in many important medicinal plants that have antihypertensive therapeutic potential. Diosmetin has been shown to have antiplatelet, anti-inflammatory and antioxidant properties, which suggests that it ...
Taseer Ahmad +6 more
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Dermatologica Sinica, 2022 Background: Psoriasis is a common skin inflammatory disease. Dysregulated growth and differentiation of keratinocytes are the main characteristics of psoriasis.
Jinyan Yang +6 more
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