Results 11 to 20 of about 4,569 (202)

Antioxidant Potential of Diosmin and Diosmetin against Oxidative Stress in Endothelial Cells

Molecules, 2022
Phlebotropic flavonoids, including diosmin and its aglycone diosmetin, are natural polyphenols widely used in the prevention and treatment of chronic venous insufficiency (CVI).
Magdalena Wójciak, Marcin Feldo, Grzegorz Borowski, Tomasz Kubrak, Bartosz J. Płachno, Ireneusz Sowa   +5 more
doaj   +4 more sources

Diosmetin protects against retinal injury via reduction of DNA damage and oxidative stress

Toxicology Reports, 2016
Visual impairment is a global public health problem that needs new candidate drugs. Chrysanthemum is a traditional Chinese drug, famous for its eye-protective function, with an unclear mechanism of action.
Zeren Shen, Jinjin Shao, Jiabin Dai, Yuchen Lin, Xiaochun Yang, Jian Ma, Qiaojun He, Bo Yang, Ke Yao, Peihua Luo   +9 more
doaj   +4 more sources

Immunomodulatory Mechanism of Baiyaojian Decoction on Periodontitis: Network Pharmacology, Single-Cell RNA Sequencing and Molecular Docking. [PDF]

J Cell Mol Med
ABSTRACT Periodontitis is one of the most common oral inflammatory diseases. Baiyaojian decoction, known for its prominent immunomodulatory and anti‐inflammatory properties, shows significant potential in treating periodontitis, though its molecular mechanisms remain unknown. The active ingredients and therapeutic targets were determined by integrating
Chen BJ, Li MM, Zheng ZY, Jin WQ, Jin Z, Zuo YL.   +5 more
europepmc   +2 more sources

A Flavonoid-Rich Extract of Scoparia dulcis L. Exhibits Antiviral Activity against Herpes Virus Type 1. [PDF]

Chem Biodivers
ABSTRACT This study investigated the phytochemical profile, cytotoxicity, and anti‐herpetic activity of the hydroethanolic extract from Scoparia dulcis L. aerial parts. Mass spectrometry revealed the presence of 15 compounds. The extract showed low cytotoxicity in Vero cells, maintaining over 80% viability at concentrations up to 250 µg/mL.
Jales FLML, Siqueira EMDS, Dantas-Medeiros R, de Araújo ERD, Alves JSF, Rocha HAO, Lopes NP, Ferreira LS, Tavares EA, Zucolotto SM.   +9 more
europepmc   +2 more sources

Diosmetin Ameliorates Vascular Dysfunction and Remodeling by Modulation of Nrf2/HO-1 and p-JNK/p-NF-κB Expression in Hypertensive Rats

Antioxidants, 2021
Diosmetin is a citrus flavonoid that has antioxidant and anti-inflammatory effects. This study examined the effect of diosmetin on blood pressure and vascular alterations and its underlying mechanisms in experimentally hypertensive rats.
Sariya Meephat, Patoomporn Prasatthong, Prapassorn Potue, Sarawoot Bunbupha, Poungrat Pakdeechote, Putcharawipa Maneesai   +5 more
doaj   +1 more source

Diosmetin Affects Gene Expression on Human Lung Adenocarcinoma Cells

Journal of Oncology, 2022
Objective. This study was aimed at investigating the effects of diosmetin (a natural flavonoid) on the gene expression of human lung adenocarcinoma (LUAD) cells. Methods. HCC827 and A549 cells were used. MTT and colony formation assay were used to investigate the effects of diosmetin on cell proliferation and colony forming activity.
Changshan Song, Shunfu Deng, Hui Hu, Zheng Zheng, Bairu Shen, Xuhui Wu, Minqian Huang, Jiaqing Wang, Zhenyu Wang   +8 more
openaire   +2 more sources

Direct Identification and Quantification of Flavonoids and Their Structural Isomers Using Ambient Ionization Tandem Mass Spectrometry. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Flavonoids are phenolic compounds with many health‐benefiting properties. However, differentiating different types of flavonoids and their isomers is challenging due to their highly similar structures of various subtypes and different numbers and sites of substituents.
Wang Y, Xu L, Gu T, Li H, Chen DDY.
europepmc   +2 more sources

Potential pharmacological mechanism of Colitis treatment by diosmetin [PDF]

, 2020
BACKGROUND AND PURPOSE Diosmetin exhibits a series of therapeutic efficacy but little is known of its effects on colitis. EXPERIMENTAL APPROACH In this study, two mouse models of DSS (the concentration of 3% and 5%)-induced colitis and Caco2 and IEC-6 cells were employed.
hailong Li, Yiying Wei, Xiaohe Li, Shanshan Zhang, hao Ruan, Shuaibo Shao, Ziwei Lv, Ruotong Zhang, Bowei Ma, Honggang Zhou, Cheng Yang   +10 more
openaire   +2 more sources

Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc signaling pathway in human osteosarcoma cells

Biological Research, 2021
Background Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical treatment, remained unknown.
Rende Ning, Guang Chen, Run Fang, Yanhui Zhang, Wenjuan Zhao, Feng Qian   +5 more
doaj   +1 more source

Characterisation, development and validation of UV Spectrophotometric technique for determining Diosmetin in bulk and nanoformulations

Results in Chemistry, 2023
Background: From ancient times, India and many other countries have utilised natural products to manage various illnesses. Because they are abundantly available and have fewer adverse effects than synthetic medications, flavonoids are secondary ...
Sumit Sheoran, Swati Arora, Himanshu Singh, Anupam Kumar, Sugunakar Vuree, Harish Vancha, Smita C Pawar   +6 more
doaj   +1 more source