Results 21 to 30 of about 4,569 (202)

Can We Improve Diosmetin Activity? The State-of-the-Art and Promising Research Directions

Molecules, 2023
Diosmetin is a natural substance widely distributed in nature, with documented multidirectional biological effects. The wide spectrum of biological activity of diosmetin gives hope that derivatives of this flavonoid may also be used as drugs or dietary ...
Monika Wujec, Marcin Feldo
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Diosmetin Protects against Cardiac Hypertrophy via p62/Keap1/Nrf2 Signaling Pathway [PDF]

Oxidative Medicine and Cellular Longevity, 2022
An important pathophysiological consequence of pressure overload‐induced cardiac hypertrophy is adverse cardiac remodeling, including structural changes in cardiomyocytes and extracellular matrix. Diosmetin (DIO), a monomethoxyflavone isolated from citrus fruits, had antioxidative stress effects in multiple organs.
Yingying Guo, Dan Li, Xian-feng Cen, Hong-liang Qiu, Yu-lan Ma, Yi Liu, Si-hui Huang, Li-bo Liu, Man Xu, Qi-Zhu Tang   +9 more
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Investigation into the in vivo mechanism of diosmetin in patients with breast cancer and COVID-19 using bioinformatics

Frontiers in Pharmacology, 2022
Patients with breast cancer are prone to SARS-CoV-2 infection [the causative virus of coronavirus disease (COVID-19)] due to their lack of immunity.
Jin Wang, Shanbo Ma, Long Li, Yuhan Chen, Yuhan Chen, Qian Yang, Feiyan Wang, Feiyan Wang, Meiling Zheng, Meiling Zheng, Shan Miao, Xiaopeng Shi   +11 more
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Diosmetin attenuate experimental ulcerative colitis in rats via suppression of NF-κB, TNF-α and IL-6 signalling pathways correlated with down-regulation of apoptotic events

European Journal of Inflammation, 2021
Introduction Ulcerative colitis (UC) is a chronic inflammation of colon in which the innermost tissue of colon and rectum develops deep-rooted inflammation.
Xiaoyan Yu, Yang Liu
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Effect of Date Palm (Phoenix dactylifera) Phytochemicals on Aβ1−40 Amyloid Formation: An in-silico Analysis

Frontiers in Neuroscience, 2022
Alzheimer's disease (AD) is a neurodegenerative disease and the most prevalent form of dementia. The generation of oxygen free radicals and oxidative damage is believed to be involved in the pathogenesis of AD.
Qamar Zia, Qamar Zia, Md Tabish Rehman, Md Amiruddin Hashmi, Sahabjada Siddiqui, Abdulaziz Bin Dukhyil, Mohammad Z. Ahmed, Azfar Jamal, Azfar Jamal, Saeed Banawas, Saeed Banawas, Saeed Banawas, Sami G. Almalki, Mohammad Owais, Hamad Qasem Aldhafeeri, Ibrahim M. Ibrahim, Wael Alturaiki, Mohamed F. AlAjmi, Mohammed Alsieni, Yaser E. Alqurashi   +19 more
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The Antioxidative Effects of Flavones in Hypertensive Disease

Biomedicines, 2023
Hypertension is the leading remediable risk factor for cardiovascular morbidity and mortality in the United States. Excess dietary salt consumption, which is a catalyst of hypertension, initiates an inflammatory cascade via activation of antigen ...
Alexandria Porcia Haynes, Selam Desta, Taseer Ahmad, Kit Neikirk, Antentor Hinton, Nathaniel Bloodworth, Annet Kirabo   +6 more
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Anti-Inflammatory and Antioxidant Effects of Diosmetin-3-O-β-d-Glucuronide, the Main Metabolite of Diosmin: Evidence from Ex Vivo Human Skin Models

Molecules, 2023
Diosmin is used to relieve chronic venous disease (CVD) symptoms. This study aimed to investigate the anti-inflammatory and antioxidant effects of diosmetin-3-O-β-d-glucuronide, the major metabolite of diosmin, using human skin explants.
Sylvie Boisnic, Marie-Christine Branchet, Barbara Quioc-Salomon, Julie Doan, Catherine Delva, Célia Gendron   +5 more
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Antioxidant Flavonoid Diosmetin Is Cardioprotective in a Rat Model of Myocardial Infarction Induced by Beta 1-Adrenergic Receptors Activation

Current Issues in Molecular Biology, 2023
Myocardial infarction (MI) is a common and life-threatening manifestation of ischemic heart diseases (IHD). The most important risk factor for MI is hypertension.
Taseer Ahmad, Taous Khan, Annet Kirabo, Abdul Jabbar Shah   +3 more
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Binding and antiplatelet activity of quercetin, rutin, diosmetin, and diosmin flavonoids

Biomedicine & Pharmacotherapy, 2021
Platelets exert an essential role in vascular inflammation and thrombosis. Flavonoids are natural compounds employed for the clinical management of vascular disorders preventing capillary permeability, working as phlebotonics and improving the blood rheology, although their mechanism of action remains partially unknown. The effects of quercetin, rutin,
Zaragozá Arnáez, Cristina, Álvarez de Mon Soto, Melchor, Monserrat Sanz, Jorge, Mantecón Ramiro, Carolina, Villaescusa Castillo, Lucinda, Álvarez de Mon González, Miguel Ángel, Zaragoza García, Francisco   +6 more
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Comprehensive review on therapeutic and phytochemical exploration of diosmetin: A promising moiety

Phytomedicine Plus, 2022
Background: Diosmetin is a biologically active flavonoid present mainly in various citrus plants and is known to exhibit wide range of potential in the treatment of various disorders.
Madhukar Garg, Sushil Kumar Chaudhary, Anju Goyal, Prerna Sarup, Sapna Kumari, Nidhi Garg, Lavish Vaid, Bhatia Shiveena   +7 more
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