Results 11 to 20 of about 10,021 (160)

Epigenetic age acceleration and clinical outcomes in gliomas.

PLoS ONE, 2020
Epigenetic age acceleration-the difference between an individual's DNA methylation age and chronological age-is associated with many diseases including cancer. This study aims to evaluate epigenetic age acceleration as a prognostic biomarker for gliomas.
Chunlei Zheng, Nathan A Berger, Li Li, Rong Xu   +3 more
doaj   +4 more sources

Exposure to Violence Accelerates Epigenetic Aging in Children [PDF]

Scientific Reports, 2017
Epigenetic processes, including DNA methylation, change reliably with age across the lifespan, such that DNA methylation can be used as an “epigenetic clock”.
Tanja Jovanovic, L. Alexander Vance, Dorthie Cross, Anna K. Knight, Varun Kilaru, Vasiliki Michopoulos, Torsten Klengel, Alicia K. Smith   +7 more
doaj   +3 more sources

Epigenetic age acceleration in hematopoietic stem cell transplantation

Haematologica
Not available.
Margherita Ursi, Katarzyna Malgorzata Kwiatkowska, Chiara Pirazzini, Gianluca Storci, Daria Messelodi, Salvatore Nicola Bertuccio, Serena De Matteis, Francesco Iannotta, Enrica Tomassini, Marcello Roberto, Maria Naddeo, Noemi Laprovitera, Irene Salamon, Barbara Sinigaglia, Elisa Dan, Francesco De Felice, Francesco Barbato, Enrico Maffini, Sadia Falcioni, Mario Arpinati, Manuela Ferracin, Massimiliano Bonafè, Paolo Garagnani, Francesca Bonifazi   +23 more
doaj   +4 more sources

Association of cardiovascular health and epigenetic age acceleration [PDF]

Clinical Epigenetics, 2021
Abstract Background Cardiovascular health (CVH) has been defined by the American Heart Association (AHA) as the presence of the “Life’s Simple 7” ideal lifestyle and clinical factors. CVH is known to predict longevity and freedom from cardiovascular disease, the leading cause of death for women in the United States.
Tess D. Pottinger, Sadiya S. Khan, Yinan Zheng, Wei Zhang, Hilary A. Tindle, Matthew Allison, Gretchen Wells, Aladdin H. Shadyab, Rami Nassir, Lisa Warsinger Martin, JoAnn E. Manson, Donald M. Lloyd-Jones, Philip Greenland, Andrea A. Baccarelli, Eric A. Whitsel, Lifang Hou   +15 more
openaire   +5 more sources

Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration. [PDF]

Brain
Abstract As the world’s population ages, more and more people are expected to suffer from age-related diseases. Biological ageing markers derived from DNA methylation and brain structure show promise in predicting health outcomes. Understanding the relationship between these biomarkers can promote the development of effective health ...
Sant'Anna Barbosa Ferreira P, van Dongen J, den Braber A, Boomsma DI, de Geus EJC, van 't Ent D.   +5 more
europepmc   +4 more sources

Accelerated epigenetic aging in Down syndrome [PDF]

Aging Cell, 2015
SummaryDown Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging
Horvath S, GARAGNANI, PAOLO, BACALINI, MARIA GIULIA, PIRAZZINI, CHIARA, SALVIOLI, STEFANO, Gentilini D, Di Blasio AM, GIULIANI, CRISTINA, Tung S, Vinters HV, FRANCESCHI, CLAUDIO   +10 more
openaire   +5 more sources

Accelerated epigenetic aging in newborns with Down syndrome [PDF]

Aging Cell, 2022
AbstractAccelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early‐onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems. Accelerated epigenetic aging has been found in the blood and brain tissue of adults with DS but when premature aging in DS begins remains unknown.
Xu, K, Li, S, Muskens, IS, Elliott, N, Myint, SS, Pandey, P, Hansen, HM, Morimoto, LM, Kang, AY, Ma, X, Metayer, C, Mueller, BA, Roberts, I, Walsh, KM, Horvath, S, Wiemels, JL, Smith, AJ   +16 more
openaire   +4 more sources

Associations between epigenetic age acceleration and infertility

Human Reproduction, 2022
AbstractSTUDY QUESTIONIs the use of ART, a proxy for infertility, associated with epigenetic age acceleration?SUMMARY ANSWERThe epigenetic age acceleration measured by Dunedin Pace of Aging methylation (DunedinPoAm) differed significantly between non-ART and ART mothers.WHAT IS KNOWN ALREADYAmong mothers who used ART, epigenetic age acceleration may be
Lee, Yunsung, Bohlin, Jon, Page, Christian Magnus, Nustad, Haakon E., Harris, Jennifer Ruth, Magnus, Per Minor, Magnus, Per, Jugessur, Astanand, Magnus, Maria Christine, Håberg, Siri Eldevik, Hanevik, Hans Ivar   +10 more
openaire   +6 more sources

Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health [PDF]

Circulation Research, 2021
Rationale: Epigenetic aging is a novel measure of biological age, reflecting exposures and disease risks independent of chronological age. It may serve as a useful biomarker of cardiovascular health (CVH) or cardiovascular disease risk for early detection or prevention.
Brian T. Joyce, Tao Gao, Yinan Zheng, Jiantao Ma, Shih-Jen Hwang, Lei Liu, Drew Nannini, Steve Horvath, Ake T. Lu, Norrina Bai Allen, David R. Jacobs, Myron Gross, Amy Krefman, Hongyan Ning, Kiang Liu, Cora E. Lewis, Pamela J. Schreiner, Stephen Sidney, James M. Shikany, Daniel Levy, Philip Greenland, Lifang Hou, Donald Lloyd-Jones   +22 more
openaire   +2 more sources

Multi-omic underpinnings of epigenetic aging and human longevity

Nature Communications, 2023
Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic data and identify ...
Lucas A. Mavromatis, Daniel B. Rosoff, Andrew S. Bell, Jeesun Jung, Josephin Wagner, Falk W. Lohoff   +5 more
doaj   +1 more source