Results 21 to 30 of about 10,021 (160)

Epigenetic Age Acceleration Is Not Associated with Age-Related Macular Degeneration [PDF]

International Journal of Molecular Sciences, 2021
DNA methylation age (DNAm age) estimation is a powerful biomarker of human ageing. To date, epigenetic clocks have not been evaluated in age-related macular degeneration (AMD). Here, we perform genome-wide DNA methylation analyses in blood of AMD patients with a documented smoking history (14 AMD, 16 Normal), identifying loci of differential ...
Neil Saptarshi, Daniel Green, Angela Cree, Andrew Lotery, Luminita Paraoan, Louise F. Porter   +5 more
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Obesity accelerates epigenetic aging of human liver [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Because obese people are at an increased risk of many age-related diseases, it is a plausible hypothesis that obesity increases the biological age of some tissues and cell types. However, it has been difficult to detect such an accelerated aging effect because it is unclear how to measure tissue age.
Horvath, Steve, Erhart, Wiebke, Brosch, Mario, Ammerpohl, Ole, von Schönfels, Witigo, Ahrens, Markus, Heits, Nils, Bell, Jordana T, Tsai, Pei-Chien, Spector, Tim D, Deloukas, Panos, Siebert, Reiner, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Schafmayer, Clemens, Hampe, Jochen   +16 more
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Alcohol consumption and epigenetic age acceleration in young adults [PDF]

Aging, 2023
Alcohol is a widely consumed substance in the United States, however its effect on aging remains understudied. In this study of young adults, we examined whether cumulative alcohol consumption, i.e., alcohol years of beer, liquor, wine, and total alcohol, and recent binge drinking, were associated with four measures of age-related epigenetic changes ...
Nannini, Drew R, Joyce, Brian T, Zheng, Yinan, Gao, Tao, Wang, Jun, Liu, Lei, Jacobs, David R, Schreiner, Pamela J, Liu, Chunyu, Dai, Qi, Horvath, Steve, Lu, Ake T, Yaffe, Kristine, Greenland, Philip, Lloyd-Jones, Donald M, Hou, Lifang   +15 more
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Cytomegalovirus infection accelerates epigenetic aging

Experimental Gerontology, 2015
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e.
Jylhava Juulia, Kananen Laura, Jylha Marja, Marttila Saara, Nevalainen Tapio, Hervonen Antti, Hurme Mikko, Hurme Mikko   +7 more
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Accelerated epigenetic aging in Werner syndrome

Aging, 2017
Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased epigenetic age according to a DNA methylation based biomarker of aging (the "Epigenetic Clock ...
Maierhofer, Anna, Flunkert, Julia, Oshima, Junko, Martin, George M, Haaf, Thomas, Horvath, Steve   +5 more
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Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants

Epigenetics, 2023
Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders ...
Seyma Katrinli, Alicia K Smith, Stacy S. Drury, Jonathan Covault, Julian D. Ford, Vijender Singh, Bo Reese, Amy Johnson, Victoria Scranton, Pamela Fall, Margaret Briggs-Gowan, Damion J Grasso   +11 more
doaj   +1 more source

Epigenetic Age Acceleration Was Delayed in Schizophrenia

Schizophrenia Bulletin, 2020
Abstract Schizophrenia is a serious neuropsychiatric disorder with abnormal age-related neurodevelopmental (or neurodegenerative) trajectories. Although an accelerated aging hypothesis of schizophrenia has been proposed, the quantitative study of the disruption of the physiological trajectory caused by schizophrenia is inconclusive.
Xiaohui, Wu, Junping, Ye, Zhongju, Wang, Cunyou, Zhao   +3 more
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Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

BMC Psychiatry, 2023
Background Schizophrenia (SCZ) is a severe and chronic psychiatric disorder with premature age-related physiological changes. However, numerous previous studies examined the epigenetic age acceleration in SCZ patients and yielded inconclusive results. In
Zongchang Li, Xiaofen Zong, David Li, Ying He, Jinsong Tang, Maolin Hu, Xiaogang Chen   +6 more
doaj   +1 more source

Epigenetic mutation load is weakly correlated with epigenetic age acceleration

Aging, 2020
DNA methylation (DNAm) age estimators are widely used to study aging-related conditions. It is not yet known whether DNAm age is associated with the accumulation of stochastic epigenetic mutations (SEMs), which reflect dysfunctions of the epigenetic maintenance system.
Yan, Qi, Paul, Kimberly C, Lu, Ake T, Kusters, Cynthia, Binder, Alexandra M, Horvath, Steve, Ritz, Beate   +6 more
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Epigenetic Age Acceleration [PDF]

Circulation: Genomic and Precision Medicine, 2018
See Article by Roetker et al Epigenetic age seems like a concept pulled from a futuristic science-fiction movie where a drop of blood is fed into a machine, in which an algorithm churns through an accumulation of chemical groups coating a strand of DNA and spits out an individual’s true age reflecting a lifetime of experiences and exposures ...
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