Results 31 to 40 of about 10,021 (160)

Epigenetic clocks derived from western samples differentially reflect Taiwanese health outcomes

Frontiers in Genetics, 2023
Introduction: Several epigenetic clocks have been developed, with five measures of epigenetic age acceleration (EAA) especially receiving extensive investigations: HannumEAA, IEAA, PhenoEAA, GrimEAA, and DunedinPACE.
Wan-Yu Lin, Wan-Yu Lin, Wan-Yu Lin
doaj   +1 more source

Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis

EBioMedicine, 2019
Background: Sleep disordered breathing (SDB) is a common disorder that results in oxidative stress and inflammation and is associated with multiple age-related health outcomes.
Xiaoyu Li, Roby Joehanes, Ina Hoeschele, Stephen S. Rich, Jerome I. Rotter, Daniel Levy, Yongmei Liu, Susan Redline, Tamar Sofer   +8 more
doaj   +1 more source

Lifetime Stress Accelerates Epigenetic Aging

European Psychiatry, 2015
Background Psychological stress is associated with accelerated cellular aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. Methods We examined the effect of stress on a DNA methylation age predictor that was shown to correlate strongly with chronological age across human tissues (Horvath 2013).
A. Zannas, T. Carrillo-Roa, S. Iurato, K. Ressler, C. Nemeroff, A. Smith, J. Lange, B. Bradley, C. Heim, T. Brückl, M. Ising, N. Wray, A. Erhardt, E. Binder, D. Mehta   +14 more
openaire   +1 more source

Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Epigenetics, 2023
Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health.
Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe, Janine F. Felix   +7 more
doaj   +1 more source

DNA repair‐deficient premature aging models display accelerated epigenetic age

Aging Cell, 2023
Abstract Several premature aging mouse models have been developed to study aging and identify interventions that can delay age‐related diseases. Yet, it is still unclear whether these models truly recapitulate natural aging.
Kevin Perez, Alberto Parras, Sara Picó, Cheyenne Rechsteiner, Amin Haghani, Robert Brooke, Calida Mrabti, Lucas Schoenfeldt, Steve Horvath, Alejandro Ocampo   +9 more
openaire   +3 more sources

DNA methylation and the epigenetic clock in relation to physical frailty in older people: the Lothian Birth Cohort 1936

Clinical Epigenetics, 2018
Background The biological mechanisms underlying frailty in older people are poorly understood. There is some evidence to suggest that DNA methylation patterns may be altered in frail individuals.
Catharine R. Gale, Riccardo E. Marioni, Sarah E. Harris, John M. Starr, Ian J. Deary   +4 more
doaj   +1 more source

Clonal Hematopoiesis and Epigenetic Age Acceleration in Elderly Danish Twins [PDF]

HemaSphere, 2022
Clonal hematopoiesis of indeterminate potential (CHIP) is common in the elderly and has been reported to associate with accelerated epigenetic age (AgeAccel), especially intrinsic (ie, cell-type independent) AgeAccel and to a lesser degree extrinsic AgeAccel, which reflects the immune-cell composition of the peripheral blood.
Sørensen, Mette, Tulstrup, Morten, Hansen, Jakob Werner, Weischenfeldt, Joachim, Gronbaek, Kirsten, Christensen, Kaare   +5 more
openaire   +4 more sources

Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study

Clinical Epigenetics, 2018
Background Recently, epigenetic age acceleration—or older epigenetic age in comparison to chronological age—has been robustly associated with mortality and various morbidities.
Marguerite R. Irvin, Stella Aslibekyan, Anh Do, Degui Zhi, Bertha Hidalgo, Steven A. Claas, Vinodh Srinivasasainagendra, Steve Horvath, Hemant K. Tiwari, Devin M. Absher, Donna K. Arnett   +10 more
doaj   +1 more source

Epigenetic Age Acceleration and Cognitive Decline: A Twin Study

The Journals of Gerontology: Series A, 2021
AbstractBackgroundLittle is known about the role of DNA methylation (DNAm) epigenetic age acceleration in cognitive decline. Using a twin study design, we examined whether DNAm age acceleration is related to cognitive decline measured longitudinally in persons without a clinical diagnosis of dementia.MethodsWe studied 266 paired male twins (133 pairs ...
Viola Vaccarino, Minxuan Huang, Zeyuan Wang, Qin Hui, Amit J Shah, Jack Goldberg, Nicholas Smith, Belal Kaseer, Nancy Murrah, Oleksiy M Levantsevych, Lucy Shallenberger, Emily Driggers, J Douglas Bremner, Yan V Sun   +13 more
openaire   +3 more sources

Epigenetic age acceleration correlates with BMI in young adults

Aging, 2023
Obesity increases the risk of Type 2 diabetes, cardiovascular disease, several types of cancer, and other age-related disorders. Among older adults, obesity is also related to epigenetic age, typically measured with DNA methylation (DNAm). Because less is known about obesity and epigenetic aging earlier in the lifespan, this study examined the ...
Foster, Christy Anne, Barker-Kamps, Malcolm, Goering, Marlon, Patki, Amit, Tiwari, Hemant K., Mrug, Sylvie   +5 more
openaire   +2 more sources