Results 41 to 50 of about 10,021 (160)

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

JHEP Reports, 2020
Background & Aims: A DNA methylation (DNAm) signature derived from 353 CpG sites (the Horvath clock) has been proposed as an epigenetic measure of chronological and biological age.
Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Aliya Gulamhusein, Kris V. Kowdley, Cynthia Levy, Zachary Goodman, Michael P. Manns, Andrew J. Muir, Christopher L. Bowlus   +12 more
doaj   +1 more source

Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus

Frontiers in Genetics, 2022
Background: Metformin has been proven to have an antiaging effect. However, studies on how metformin affects global epigenetic regulation and its effect on the epigenetic clock in diabetes mellitus (DM) patients are limited.
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
doaj   +1 more source

Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

Clinical Epigenetics, 2023
Background Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biological process of aging. Epigenetic
Yosra Bejaoui, Fathima Humaira Amanullah, Mohamad Saad, Sara Taleb, Martina Bradic, Andre Megarbane, Ali Ait Hssain, Charbel Abi Khalil, Nady El Hajj   +8 more
doaj   +1 more source

Infant’s DNA Methylation Age at Birth and Epigenetic Aging Accelerators

BioMed Research International, 2016
Knowing the biological age of the neonates enables us to evaluate and better understand the health and maturity comprehensively. However, because of dearth of biomarkers, it is difficult to quantify the neonatal biological age. Here we sought to quantify and assess the variability in biological age at birth and to better understand how the aging rates ...
Ruheena Javed, Weidan Chen, Fangqin Lin, Huiying Liang   +3 more
openaire   +2 more sources

Epigenetic aging in cows is accelerated by milk production

Epigenetics, 2023
DNA methylation has proven to be the most promising age-predictive biomarker in mammals resulting in the emergence of 'epigenetic clocks' that describe the relationship between methylation levels and age. Using Targeted bisulfite Sequencing, we evaluated blood DNA-methylation data from 96 domesticated cows (Bos Taurus) of which 88 were adults and 8 ...
Prashansa Ratan, Liudmilla Rubbi, Michael Thompson, Kaushik Naresh, Jolena Waddell, Barbara Jones, Matteo Pellegrini   +6 more
openaire   +3 more sources

Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort

Epigenetics, 2022
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood.
Saher Daredia, Karen Huen, Lars Van Der Laan, Philip A. Collender, Jamaji C. Nwanaji-Enwerem, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Nina Holland, Andres Cardenas   +9 more
doaj   +1 more source

Open access-enabled evaluation of epigenetic age acceleration in colorectal cancer and development of a classifier with diagnostic potential

Frontiers in Genetics, 2023
Aberrant DNA methylation (DNAm) is known to be associated with the aetiology of cancer, including colorectal cancer (CRC). In the past, the availability of open access data has been the main driver of innovative method development and research training ...
Tyas Arum Widayati, Jadesada Schneider, Jadesada Schneider, Kseniia Panteleeva, Elizabeth Chernysheva, Natalie Hrbkova, Stephan Beck, Vitaly Voloshin, Olga Chervova   +8 more
doaj   +1 more source

Epigenetic analysis confirms no accelerated brain aging in schizophrenia [PDF]

npj Schizophrenia, 2017
AbstractEpigenetic aging is associated with several biological mechanisms and diseases. We assessed two brain data sets, one small (n = 48) and one large (n = 392), to test epigenetic aging in schizophrenia. DNA methylation age from frontal cortex was significantly correlated with chronological age but no significant differences in DNA methylation age ...
Joanne Voisey, Bruce R. Lawford, C. Phillip Morris, Leesa F. Wockner, Ernest P. Noble, Ross McD Young, Divya Mehta   +6 more
openaire   +3 more sources

Adolescent peer struggles predict accelerated epigenetic aging in midlife

Development and Psychopathology, 2022
AbstractThis study examined struggles to establish autonomy and relatedness with peers in adolescence and early adulthood as predictors of advanced epigenetic aging assessed at age 30. Participants (N= 154; 67 male and 87 female) were observed repeatedly, along with close friends and romantic partners, from ages 13 through 29.
Joseph P. Allen, Joshua S. Danoff, Meghan A. Costello, Emily L. Loeb, Alida A. Davis, Gabrielle L. Hunt, Simon G. Gregory, Stephanie N. Giamberardino, Jessica J. Connelly   +8 more
openaire   +2 more sources

Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth

Epigenetics, 2022
Maternal pregnancy fatty acid status is associated with child health. Epigenetic gestational age acceleration, referring to a discrepancy between chronological and epigenetic gestational age, may underlie these associations.
Giulietta S. Monasso, Trudy Voortman, Janine F. Felix   +2 more
doaj   +1 more source