Results 51 to 60 of about 10,021 (160)

Bloom syndrome patients and mice display accelerated epigenetic aging

Aging Cell, 2023
AbstractBloom syndrome (BSyn) is an autosomal recessive disorder caused by variants in the BLM gene, which is involved in genome stability. Patients with BSyn present with poor growth, sun sensitivity, mild immunodeficiency, diabetes, and increased risk of cancer, most commonly leukemias.
Jamie Lee, Joshua Zhang, Maeve Flanagan, Julian A. Martinez, Christopher Cunniff, Nicole Kucine, Ake T. Lu, Amin Haghani, Juozas Gordevičius, Steve Horvath, Vivian Y. Chang   +10 more
openaire   +4 more sources

Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study

BMC Medicine
Background Few studies have examined associations between maternal epigenetic age acceleration and adverse birth outcomes, and none have investigated paternal epigenetic age acceleration.
Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus, Siri E. Håberg   +10 more
doaj   +1 more source

Association of Epigenetic Age and Outcome in Critically Ill Patients

Critical Care Explorations
OBJECTIVES:. DNA methylation can be used to determine an individual’s biological age, as opposed to chronological age, an indicator of underlying health status.
Archana Sharma-Oates, PhD, Jack Sullivan, PhD, Daniel Pestana, MSc, Claudia C. dos Santos, MD, Alexandra Binnie, MD, Janet M. Lord, PhD   +5 more
doaj   +1 more source

Accelerated Epigenetic Ageing in Major Depressive Disorder [PDF]

, 2017
AbstractBackgroundMajor depressive disorder (MDD) is a severe, heritable psychiatric disorder associated with shortened lifespan and comorbidities of advancing age. It is unknown however whether MDD is associated with accelerated biological ageing relative to chronological age.
Whalley, Heather C, Gibson, Jude, Marioni, Riccardo, Walker, Rosie M, Clarke, Toni-Kim, Howard, David M, Adams, Mark J, Hall, Lynsey, Morris, Stewart, Deary, Ian J, Porteous, David, Evans, Kathryn L, McIntosh, Andrew M   +12 more
openaire   +1 more source

Alcohol consumption and epigenetic age acceleration across human adulthood

Aging, 2023
The alcohol-associated biological aging remains to be studied across adulthood. We conducted linear regression analyses to investigate the associations between alcohol consumption and two DNA methylation-based biological age acceleration metrics in 3823 Framingham Heart Study participants (24-92 years and 53.8% women) adjusting for covariates.
Wang, Mengyao, Li, Yi, Lai, Meng, Nannini, Drew R., Hou, Lifang, Joehanes, Roby, Huan, Tianxiao, Levy, Daniel, Ma, Jiantao, Liu, Chunyu   +9 more
openaire   +2 more sources

Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm

Epigenetics, 2023
Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neonatal period in preterm infants, who are at heightened risk
Uriel Paniagua, Barry M. Lester, Carmen J. Marsit, Marie Camerota, Brian S. Carter, Jennifer F. Check, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, T. Michael O’Shea, Todd M. Everson   +15 more
doaj   +1 more source

Epigenetic Age Acceleration Assessed with Human White-Matter Images [PDF]

The Journal of Neuroscience, 2017
The accurate estimation of age using methylation data has proved a useful and heritable biomarker, with acceleration in epigenetic age predicting a number of age-related phenotypes. Measures of white matter integrity in the brain are also heritable and highly sensitive to both normal and pathological aging processes across adulthood.
Karen Hodgson, Melanie A. Carless, Hemant Kulkarni, Joanne E. Curran, Emma Sprooten, Emma E. Knowles, Samuel Mathias, Harald H.H. Göring, Nailin Yao, Rene L. Olvera, Peter T. Fox, Laura Almasy, Ravi Duggirala, John Blangero, David C. Glahn   +14 more
openaire   +3 more sources

Decreased but persistent epigenetic age acceleration is associated with changes in T-cell subsets after initiation of highly active antiretroviral therapy in persons living with HIV

Frontiers in Bioinformatics
IntroductionPersons living with HIV (PLWH) experience the early onset of age-related illnesses, even in the setting of successful human immunodeficiency virus (HIV) suppression with highly active antiretroviral therapy (HAART).
Mary E. Sehl, Mary E. Sehl, Elizabeth Crabb Breen, Roger Shih, Fengxue Li, Joshua Zhang, Peter Langfelder, Peter Langfelder, Steve Horvath, Steve Horvath, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Beth D. Jamieson   +17 more
doaj   +1 more source

Short Sleep and Insomnia Are Associated With Accelerated Epigenetic Age

Psychosomatic Medicine, 2022
ABSTRACT Objective Short sleep and insomnia are each associated with a greater risk of age-related disease, which suggests that insufficient sleep may accelerate biological aging. We examine whether short sleep and insomnia alone or together relates to epigenetic age among older adults.
Cynthia D.J. Kusters, Eric T. Klopack, Eileen M. Crimmins, Teresa E. Seeman, Steve Cole, Judith E. Carroll   +5 more
openaire   +2 more sources

Sex differences in epigenetic ageing for older people living with HIVResearch in context

EBioMedicine
Summary: Background: HIV-1 infection impacts biological ageing, and epigenetic clocks highlight epigenetic age acceleration in people with HIV. Despite evidence indicating sex differences in clinical, immunological, and virological measures, females ...
Carrie D. Johnston, Alina P.S. Pang, Eugenia L. Siegler, Charlene Thomas, Chelsie O. Burchett, Mia Crowley, Rochelle O'Brien, Lishomwa C. Ndhlovu, Marshall J. Glesby, Michael J. Corley   +9 more
doaj   +1 more source