Results 61 to 70 of about 10,021 (160)
Ecological Realism Accelerates Epigenetic Aging in Mice
Aging CellABSTRACTThe aging of mammalian epigenomes fundamentally alters cellular functions, and such changes are the focus of many healthspan and lifespan studies. However, studies of this process typically use mouse models living under standardized laboratory conditions and neglect the impact of variation in social, physical, microbial, and other aspects of ...
Matthew N. Zipple +5 more
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An older subjective age is related to accelerated epigenetic aging.
Psychology and Aging, 2021 The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge.
Yannick Stephan +3 more
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BMC Genomics, 2021 Background Aging and inflammation are important components of Parkinson’s disease (PD) pathogenesis and both are associated with changes in hematopoiesis and blood cell composition. DNA methylation (DNAm) presents a mechanism to investigate inflammation,
Kimberly C Paul +8 more
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陆军军医大学学报Objective To investigate the potential causal associations between 3 common subjective sleep problems, daytime sleepiness, insomnia, and sleep apnea, and epigenetic age acceleration.
LI Xiaomei, REN Hao, ZHANG Zheng
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Epigenetic age acceleration and mortality risk prediction in US adults. [PDF]
GeroscienceAbstractBackgroundEpigenetic clocks have emerged as novel measures of biological age and potential predictors of mortality. We aimed to test whether epigenetic age acceleration (EAA) estimated using different epigenetic clocks predict long-term overall, cardiovascular or cancer mortality.MethodsWe analyzed data from 2,105 participants to the 1999-2002 ...
Mendy A, Mersha TB.
europepmc +5 more sources
Increased epigenetic age in normal breast tissue from luminal breast cancer patients
Clinical Epigenetics, 2018 Background Age is one of the most important risk factors for developing breast cancer. However, age-related changes in normal breast tissue that potentially lead to breast cancer are incompletely understood.
Erin W. Hofstatter +17 more
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Environment International, 2020 Background: Perfluoroalkyl substances (PFAS) are widespread synthetic substances with various adverse health effects. A potential mechanism of toxicity for PFAS is via epigenetic changes, such as DNA methylation.
Yiyi Xu +6 more
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Occupational characteristics and epigenetic aging among older adults in the United States
Epigenetics, 2023 Occupational characteristics have been studied as risk factors for several age-related diseases and are thought to impact the ageing process, although there has been limited empirical work demonstrating an association between adverse occupational ...
Theresa Andrasfay, Eileen Crimmins
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Genetic and environmental contributions to epigenetic aging across adolescence and young adulthood
Clinical EpigeneticsBackground Epigenetic aging estimators commonly track chronological and biological aging, quantifying its accumulation (i.e., epigenetic age acceleration) or speed (i.e., epigenetic aging pace).
Dmitry V. Kuznetsov +12 more
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Accelerated epigenetic ageing after burn injury
GeroScienceAbstract Individuals who suffer a major burn injury are at higher risk of developing a range of age-associated diseases prematurely leading to an increase in mortality in adult and juvenile burn injury survivors. One possible explanation is that injury is accelerating the biological ageing process.
Jack Sullivan +4 more
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