Results 71 to 80 of about 10,021 (160)

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Genome Biology, 2019
Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments.
Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill, Leonard C. Schalkwyk   +10 more
doaj   +1 more source

Epigenetic aging acceleration among World Trade Center-exposed community members

Scientific Reports
Aging is a complex biological process, and some individuals are aging faster or slower than expected. This phenomenon of aging acceleration occurs when biological age exceeds chronological age and can be assessed by epigenetic clock estimation.
Stephanie Tuminello, Yibeltal Arega Ashebir, Chanel Schroff, Sitharam Ramaswami, Nedim Durmus, Yu Chen, Matija Snuderl, Yongzhao Shao, Joan Reibman, Alan A. Arslan   +9 more
doaj   +1 more source

Does accelerated epigenetic ageing predict accelerated future musculoskeletal ageing?

, 2022
The ability to predict those at risk of more rapid musculoskeletal ageing is vital if therapeutic strategies are to be successful. Precise description of the ageing musculoskeletal phenotype combined with the mapping of epigenetic changes, specifically those within the DNA methylome, enable precise age prediction and ‘epigenetic clocks’ have been ...
openaire   +1 more source

Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older U.S. adults

BMC Medical Genomics
Background Dyslipidemia, which is characterized by an unfavorable lipid profile, is a key risk factor for cardiovascular disease (CVD). Understanding the relationships between epigenetic aging and lipid levels may help guide early prevention and ...
Lisha Lin, Jenna Kiryakos, Farah Ammous, Scott M. Ratliff, Erin B. Ware, Jessica D. Faul, Sharon L.R. Kardia, Wei Zhao, Kira S. Birditt, Jennifer A. Smith   +9 more
doaj   +1 more source

Epigenetic age and neurodevelopmental outcomes in children born preterm

Genetics in Medicine Open
Purpose: The objective of this study was to identify predictors of epigenetic age and its association with neurodevelopmental outcomes in children born preterm.
Rhandi Christensen, Chaini Konwar, Beryl C. Zhuang, Michael S. Kobor, Vann Chau, Anne Synnes, Ting Guo, Julia MacIsaac, Ruth E. Grunau, Steven P. Miller   +9 more
doaj   +1 more source

Heavy metals, epigenetic aging, and mortality: A cohort study

Ecotoxicology and Environmental Safety
Background: Aging is a multifaceted biological process modulated by interplay of genetic determinants and environmental influences. However, the role of epigenetic aging in the association between environmental exposures and mortality risk in human ...
Hua Wang, Yunyun Liu, Shuxiang Yan, Chenbei Li, Jinxin Tang, Hongkun Hu, Mingyang Wu, Chao Tu   +7 more
doaj   +1 more source

Neighborhood Stressors and Epigenetic Age Acceleration Among Older Americans. [PDF]

J Gerontol B Psychol Sci Soc Sci
Abstract Objectives Exposure to stressful neighborhood environments is a well-established risk factor for health deterioration and premature death. However, the biological underpinnings are not fully understood.
Choi EY, Ailshire JA.
europepmc   +4 more sources

Distinct epigenetic aging in sporadic and hereditary neuroendocrine neoplasms

Clinical Epigenetics
Background Epigenetic clocks assess DNA aging based on DNA methylation. We aimed to study the utility of methylation clocks in understanding the distinct characteristics of sporadic and hereditary neuroendocrine neoplasms (NEN).
Shiri Weinstein, Reut Halperin, Amit Tirosh   +2 more
doaj   +1 more source

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

Clinical Epigenetics, 2018
Background Epigenetic age acceleration (an older methylation age compared to chronological age) correlates strongly with various age-related morbidities and mortality.
Anna J. Stevenson, Daniel L. McCartney, Sarah E. Harris, Adele M. Taylor, Paul Redmond, John M. Starr, Qian Zhang, Allan F. McRae, Naomi R. Wray, Tara L. Spires-Jones, Barry W. McColl, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni   +13 more
doaj   +1 more source

Epigenetic age and cardiometabolic disease in Guatemalan adults: a cross-sectional analysis

Journal of Health, Population and Nutrition
Background Epigenetic clocks, biomarkers of aging, show older biological ages among individuals with cardiometabolic disease. Epigenetic age acceleration, often calculated as the residuals from regressing epigenetic age on chronological age, reflects ...
Melissa A. Chapnick, Elaine A. Yu, Alicia K. Smith, Karen N. Conneely, Manuel Ramírez-Zea, Zhaohui S. Qin, Lisa R. Staimez, Viola Vaccarino, Aryeh D. Stein   +8 more
doaj   +1 more source