Results 11 to 20 of about 1,435 (170)
Clinical Perspectives in Epitranscriptomics [PDF]
Current Opinion in Genetics & DevelopmentEpitranscriptomics, the study of reversible and dynamic chemical marks on the RNA, is rapidly emerging as a pivotal field in post-transcriptional gene expression regulation.
Esteller, Manel +2 more
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Epitranscriptomics: mapping methods and beyond [PDF]
BioTechniques, 2018 The field of epigenetics has changed the way we look at both DNA and proteins. Could the same be true for RNA? Joseph Martin discusses. [Graphic: see text]
Joseph Martin
doaj +2 more sources
Epitranscriptomics in myeloid malignancies
Blood Science, 2022 Li Han, Jianjun Chen, Rui Su
doaj +3 more sources
The epitranscriptome toolbox [PDF]
Cell, 2022 In the last decade, the notion that mRNA modifications are involved in regulation of gene expression was demonstrated in thousands of studies. To date, new technologies and methods allow accurate identification, transcriptome-wide mapping, and functional characterization of a growing number of RNA modifications, providing important insights into the ...
Moshitch-Moshkovitz, Sharon +2 more
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Environmental epitranscriptomics [PDF]
Environmental Research, 2020 Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6 ...
Cayir, Akin +2 more
openaire +4 more sources
Viral Epitranscriptomics [PDF]
Journal of Virology, 2017 ABSTRACT Although it has been known for over 40 years that eukaryotic mRNAs bear internal base modifications, it is only in the last 5 years that the importance of these modifications has begun to come into focus. The most common mRNA modification, the addition of a methyl group to the N 6 ...
Edward M, Kennedy +3 more
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Functional roles of epitranscriptomic marks in the cardiovascular system and disease: a narrative review [PDF]
, 2022 BACKGROUND AND OBJECTIVE: The recent emergence of epitranscriptomics provides an avenue for identifying RNA modifications implicated in the pathophysiology of human disease.
Ilieva, Mirolyuba Simeonova +1 more
core +1 more source
The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity
Frontiers in Immunology, 2023 The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has had a significant impact on global social and economic stability.
Xuan Wang +6 more
doaj +1 more source
Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives [PDF]
, 2021 Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors.
Biancari, Fausto +38 more
core +6 more sources
Translating the epitranscriptome [PDF]
WIREs RNA, 2016 RNAmodifications are indispensable for the translation machinery to provide accurate and efficient protein synthesis. Whereas the importance of transfer RNA (tRNA) and ribosomal RNA (rRNA) modifications has been well described and is unquestioned for decades, the significance of internal messenger RNA (mRNA) modifications has only recently been ...
Hoernes, Thomas Philipp +1 more
openaire +2 more sources