Results 21 to 30 of about 1,435 (170)

Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2′-O-Methylations in RNA by RiboMethSeq

Frontiers in Genetics, 2020
A major trend in the epitranscriptomics field over the last 5 years has been the high-throughput analysis of RNA modifications by a combination of specific chemical treatment(s), followed by library preparation and deep sequencing.
Florian Pichot, Florian Pichot, Florian Pichot, Virginie Marchand, Lilia Ayadi, Lilia Ayadi, Valérie Bourguignon-Igel, Valérie Bourguignon-Igel, Mark Helm, Yuri Motorin, Yuri Motorin   +10 more
doaj   +1 more source

Positioning Europe for the EPITRANSCRIPTOMICS challenge [PDF]

, 2018
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built.
Almeida, Raquel, Ameres, Stefan, Ayers, Duncan, Balatsos, Nikolaos, Ballana, Ester, Bankovic, Jasna, Banovic, Bojana, Baranov, Pavel, Bousquet-Antonelli, Cecile, Bujnicki, Janusz, Cardona, Fernando, Carre, Clement, Costache, Marieta, Cowling, Victoria, Dahl, John Arne, Davalos, Alberto, David, Alexandre, Demircan, Turan, Dinnyes, Andras, Drablos, Finn, Fray, Rupert, Frye, Michaela, Fuks, Francois, Helm, Mark, Holodnuka Kholodnyuk, Irina, Jantsch, Michael, Jeronimo, Carmen, Kelly, Vincent, Klungland, Arne, Kyselovic, Jan, Lafontaine, Denis, Lamm, Ayelet, Liepins, Janis, Lyko, Frank, Macias-Gonzales, Manuel, Motorin, Yuri, Neagu, Monica, Nielsen, Henrik, O Carroll, Donal, O'Connell, Mary, Ohman, Marie, Oulas, Anastasis, Pelizzola, Mattia, Pir, Pinar, Purta, Elzbieta, Quattrone, Alessandro, Rechavi, Gideon, Roignant, Jean-Yves, Rossmanith, Walter, Schaffrath, Raffael, Schwartz, Schraga, Schäfer, Matthias, Selbert, Stefan, Timotijevic, Gordana, Ule, Jernej, Valor, Luis Miguel, Vanacova, Stepanka, Verdel, Andre, Willems, Luc, Zammit, Vanessa   +59 more
core   +13 more sources

Epitranscriptome changes triggered by ammonium nutrition regulate the proteome response of maritime pine roots. [PDF]

, 2022
Epitranscriptome constitutes a gene expression checkpoint in all living organisms. Nitrogen is an essential element for plant growth and development that influences gene expression at different levels such as epigenome, transcriptome, proteome, and ...
Cañas-Pendón, Rafael Antonio, Cánovas-Ramos, Francisco Miguel, Lobato-Fernández, César, Ortigosa Peña, Francisco, Pérez-Claros, Juan Antonio, Ruiz-Canton, Francisco Javier, Ávila-Sáez, Concepción   +6 more
core   +1 more source

tRNA biology in the omics era: Stress signalling dynamics and cancer progression. [PDF]

, 2017
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transition from a gene-centred to a genome-centred perspective, tRNAs and other RNA polymerase III transcripts surfaced as active regulators of normal cell ...
Adelman, Anderson, Anderson, Arimbasseri, Arimbasseri, Barski, Bartholomew, Basturea, Behm-Ansmant, Blanco, Bogenhagen, Boguta, Bonhoure, Canella, Canella, Carlile, Carrire, Chan, Chan, Choi, Clarke, Conti, Core, Cozen, Crick, Danko, David, de Nadal, Deng, Dieci, Dittmar, Dittmar, Duechler, Ebhardt, Flusberg, Gingold, Goodarzi, Goodarzi, Granneman, Grewal, Guenther, Guy, Harismendy, Hiley, Hoagland, Holley, Honda, Hou, Huang, Hussain, Iida, Ishimura, Ivanov, Johnson, Jordan-Pla, Kadaba, Kassavetis, Kedinger, Khoddami, Kim, Kumar, Kumar, Kumar, Kutter, Lampson, Laplante, Li, Li, Lin, Linder, Liu, Liu, Lowe, Lund, Mahlab, Marchand, Mayer, Michels, Moqtaderi, Moqtaderi, Nagarajavel, Nedialkova, Noma, Oler, Oler, Orioli, Orioli, Pang, Pavesi, Pavon-Eternod, Pavon-Eternod, Percudani, Pershing, Phizicky, Pombo, Pugh, Qian, Raha, Renaud, Rhee, Rideout, Roberts, Roeder, Ross, Rudolph, Ryvkin, Saikia, Saikia, Sakurai, Sakurai, Schaefer, Schmitt, Schwartz, Shor, Shukla, Simms, Sutherland, Thurman, Torres, Torres, Turowski, Vannini, Varshney, Vilfan, Weinmann, White, Zheng, Zhou   +127 more
core   +1 more source

Epitranscriptomics in normal and malignant hematopoiesis [PDF]

, 2020
Epitranscriptomics analyze the biochemical modifications borne by RNA and their downstream influence. From this point of view, epitranscriptomics represent a new layer for the control of genetic information and can affect a variety of molecular processes
Albano F., Anelli L., Impera L., Minervini C. F., Musto P., Parciante E., Specchia G., Zagaria A.   +7 more
core   +1 more source

Flavin-dependent epitranscriptomic world [PDF]

Archives of Biochemistry and Biophysics, 2017
RNAs molecules fulfill key roles in the expression and regulation of the genetic information stored within the DNA chromosomes. In addition to the four canonical bases, U, C, A and G, RNAs harbor various chemically modified derivatives which are generated post-transcriptionally by specific enzymes acting directly at the polymer level.
Lombard, Murielle, Hamdane, Djemel
openaire   +3 more sources

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources

Writers, readers and erasers of RNA modifications in cancer [PDF]

, 2020
Although cancer was originally considered a disease driven only by genetic mutations, it has now been proven that it is also an epigenetic disease driven by DNA hypermethylation-associated silencing of tumor suppressor genes and aberrant histone ...
Bueno-Costa, Alberto, Esteller, M., Esteve-Puig, R., Universitat Autònoma de Barcelona   +3 more
core   +4 more sources

tRNA epitranscriptomics and biased codon are linked to proteome expression in [PDF]

, 2018
Among components of the translational machinery, ribonucleoside modifications on tRNAs are emerging as critical regulators of cell physiology and stress response. Here, we demonstrate highly coordinated behavior of the repertoire of tRNA modifications of
Aniweh, Yaw, Babu, Indrakanti Ramesh, Chionh, Yok Hian, Dedon, Peter C, Gu, Chen, Nah, Qianhui, Ng, Chee Sheng, Preiser, Peter R, Sinha, Ameya   +8 more
core   +1 more source

Epitranscriptomics of cancer

World Journal of Clinical Oncology, 2018
The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported.
Tusup, Marina, Kundig, Thoma, Pascolo, Steve   +2 more
openaire   +2 more sources