Results 61 to 70 of about 1,435 (170)

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Ribosomal RNA 2′O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer [PDF]

, 2020
International audienceRecent epitranscriptomics studies unravelled that ribosomal RNA (rRNA) 2′O-methylation is an additional layer of gene expression regulation highlighting the ribosome as a novel actor of translation control.
André, Fabrice, Ayadi, Lilia, Bourdon, Jean-Christophe, Bourguignon-Igel, Valérie, Bray, Susan E., Catez, Frédéric, Diaz, Jean-Jacques, Diot, Alexandra, Dubois, Thierry, Jordan, Lee B., Kielbassa, Janice, Klaholz, Bruno p, Lo Monaco, Piero, Marcel, Virginie, Marchand, Virginie, Monchiet, Déborah, Motorin, Yuri, Natchiar, Kundhavai s, Nguyen Van Long, Flora, Paraqindes, Hermes, Puisieux, Alain, Scott, Véronique, Thompson, Alastair M, Tonon, Laurie, Viari, Alain   +24 more
core   +4 more sources

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Statistical modeling of immunoprecipitation efficiency of MeRIP-seq data enabled accurate detection and quantification of epitranscriptome

Computational and Structural Biotechnology Journal
Background: Recent advancements in epitranscriptomics highlight reversible RNA modifications as crucial regulators, with N6-methyladenosine (m6A) being abundant in eukaryotic mRNAs.
Haozhe Wang, Kunqi Chen, Zhen Wei, Bowen Song, Manli Zhu, Jionglong Su, Anh Nguyen, Jia Meng, Yue Wang   +8 more
doaj   +1 more source

m6A reader proteins: the executive factors in modulating viral replication and host immune response

Frontiers in Cellular and Infection Microbiology, 2023
N6-Methyladenosine (m6A) modification is the most abundant covalent modification of RNA. It is a reversible and dynamic process induced by various cellular stresses including viral infection.
Decheng Yang, Decheng Yang, Guangze Zhao, Guangze Zhao, Huifang Mary Zhang, Huifang Mary Zhang   +5 more
doaj   +1 more source

An informatics approach to distinguish RNA modifications in nanopore direct RNA sequencing [PDF]

, 2022
Reading RNA modifications more precisely in a pocket-sized device. 京都大学プレスリリース. 2022-08-24.Modifications in RNA can influence their structure, function, and stability and play essential roles in gene expression and regulation.
Fujita, Yoto, Kovi, Basavaraj, Mishra, Shubham, Pandian, Ganesh N, Parimalam, Sangamithirai Subramanian, Ramasamy, Soundhar, Sharma, Surbhi, Sugiyama, Hiroshi, Vaijayanthi, Thangavel   +8 more
core   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

N6-methyladenosine (m6A) RNA modification as a metabolic switch between plant cell survival and death in leaf senescence

Frontiers in Plant Science, 2023
Crop losses caused by climate change and various (a)biotic stressors negatively affect agriculture and crop production. Therefore, it is vital to develop a proper understanding of the complex response(s) to (a)biotic stresses and delineate them for each ...
Elżbieta Rudy, Magda Grabsztunowicz, Magdalena Arasimowicz-Jelonek, Umesh Kumar Tanwar, Julia Maciorowska, Ewa Sobieszczuk-Nowicka   +5 more
doaj   +1 more source

Aging through an epitranscriptomic lens

Nature Aging, 2021
The mechanistic causes of aging, the time-related decline in function and good health that leads to increased mortality, remain poorly understood. Here we propose that age-dependent alteration of the epitranscriptome, encompassing more than 150 chemically distinct post-transcriptional modifications or editing events, warrants exploration as an ...
Mary McMahon, Craig Forester, Rochelle Buffenstein   +2 more
openaire   +2 more sources

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source