Results 1 to 10 of about 6,722 (136)

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system. [PDF]

PLoS ONE, 2012
ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Raf Ponsaerts, Catheleyne D'hondt, Fréderic Hertens, Jan B Parys, Luc Leybaert, Johan Vereecke, Bernard Himpens, Geert Bultynck   +7 more
doaj   +4 more sources

Extracellular cysteine in connexins: role as redox sensors [PDF]

Frontiers in Physiology, 2016
Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Mauricio Antonio Retamal, Isaac E García, Bernardo ePinto, Amaury ePupo, David eBaez-Nieto, Jimmy eStehberg, RODRIGO eDEL RIO, Carlos eGonzalez   +7 more
doaj   +4 more sources

Cues to Opening Mechanisms From in Silico Electric Field Excitation of Cx26 Hemichannel and in Vitro Mutagenesis Studies in HeLa Transfectans [PDF]

Frontiers in Molecular Neuroscience, 2018
Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Francesco Zonta, Francesco Zonta, Damiano Buratto, Damiano Buratto, Damiano Buratto, Giulia Crispino, Giulia Crispino, Giulia Crispino, Andrea Carrer, Andrea Carrer, Andrea Carrer, Francesca Bruno, Guang Yang, Fabio Mammano, Fabio Mammano, Fabio Mammano, Fabio Mammano, Sergio Pantano   +17 more
doaj   +3 more sources

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons [PDF]

Frontiers in Cellular Neuroscience, 2015
Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Juan Andrés Orellana, Rodrigo eMoraga-Amaro, Raúl eDíaz-Galarce, sebastian eRojas, Carola J Maturana, Jimmy eStehberg, Juan C Saez   +6 more
doaj   +4 more sources

The action of mimetic peptides on connexins protects fibroblasts from the negative effects of ischemia reperfusion [PDF]

Biology Open, 2015
Connexins have been proposed as a target for therapeutic treatment of a variety of conditions. The main approaches have been by antisense or small peptides specific against connexins.
Beverley J. Glass, Rebecca G. Hu, Anthony R. J. Phillips, David L. Becker   +3 more
doaj   +3 more sources

Tonabersat suppresses priming/activation of the NOD-like receptor protein-3 (NLRP3) inflammasome and decreases renal tubular epithelial-to-macrophage crosstalk in a model of diabetic kidney disease [PDF]

Cell Communication and Signaling
Background Accompanied by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP release is situated upstream of inflammasome assembly and inflammation and contributes to multiple ...
C. L. Cliff, P. E. Squires, C. E. Hills
doaj   +2 more sources

Connexin 43 and Pannexin 1 hemichannels as endogenous regulators of innate immunity in sepsis [PDF]

Frontiers in Immunology
Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infections that is initiated by the body’s innate immune system. Nearly a decade ago, we discovered that bacterial lipopolysaccharide (LPS) and serum amyloid A (
Jianhua Li, Li Lou, Weiqiang Chen, Weiqiang Chen, Xiaoling Qiang, Xiaoling Qiang, Cassie Zhu, Cassie Zhu, Haichao Wang, Haichao Wang   +9 more
doaj   +2 more sources

Bracovirus-mediated innexin hemichannel closure in cell disassembly

iScience, 2021
Summary: Cell-cell communication is necessary for cellular immune response. Hemichannel closure disrupts communication between intracellular and extracellular environments during polydnavirus-induced immunosuppression in invertebrates.
Chang-Xu Chen, Hao-Juan He, Qiu-Chen Cai, Wei Zhang, Tian-Chao Kou, Xue-Wen Zhang, Shan You, Ya-Bin Chen, Tian Liu, Wei Xiao, Qi-Shun Zhu, Kai-Jun Luo   +11 more
doaj   +1 more source

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes [PDF]

, 2014
In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct ...
Abudara, Verónica, Bechberger, John, Bultynck, Geert, De Bock, Marijke, Freitas-Andrade, Moises, Giaume, Christian, Leybaert, Luc, Naus, Christian C, Wang, Nan   +8 more
core   +13 more sources

Synthesis and Biological Evaluation of Termini-Modified and Cyclic Variants of the Connexin43 Inhibitor Peptide5

Frontiers in Chemistry, 2022
Peptide5 is a 12–amino acid mimetic peptide that corresponds to a region of the extracellular loop 2 (EL2) of connexin43. Peptide5 regulates both cellular communication with the cytoplasm (hemichannels) and cell-to-cell communication (gap junctions), and
Sin Hang Crystal Chan, Jarred M. Griffin, Connor A. Clemett, Margaret A. Brimble, Margaret A. Brimble, Margaret A. Brimble, Simon J. O’Carroll, Paul W. R. Harris, Paul W. R. Harris, Paul W. R. Harris   +9 more
doaj   +1 more source