Results 91 to 100 of about 6,791 (202)

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source

Characterization of Nonjunctional Hemichannels in Caterpillar Cells [PDF]

Journal of Insect Science, 2011
Recent studies have demonstrated that hemichannels, which form gap junctions when paired from apposing cells, may serve additional roles when unpaired including cell adhesion and paracrine communication. Hemichannels in mammals are formed by connexins or pannexins, while in insects they are formed by pannexin homologues termed innexins.
Luo, Kaijun, Turnbull, Matthew W.
openaire   +2 more sources

Overexpression of Cx43: Is It an Effective Approach for the Treatment of Cardiovascular Diseases?

Biomolecules
In the heart, Connexin 43 (Cx43) is involved in intercellular communication through gap junctions and exosomes. In addition, Cx43-formed hemichannels at the plasma membrane are important for ion homeostasis and cellular volume regulation.
Kerstin Boengler, Beatrice Mantuano, Shira Toledano, Ofer Binah, Rainer Schulz   +4 more
doaj   +1 more source

Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration. [PDF]

, 2016
Our previous reports indicate that ligand-induced αVβ3 integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes.
Alvarez, A., Burgos-Bravo, F., Cárdenas, A., Kong, M., Lagos-Cabré, R., Leyton, L., Quest, A.F., Schneider, P.   +7 more
core   +2 more sources

Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives

The Journal of Physiology, Volume 604, Issue 4, Page 1592-1606, 15 February 2026.
Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu, Laura Beth Payne, Robert G. Gourdie   +2 more
wiley   +1 more source

Connexin 43 Hemichannels Are Permeable to ATP [PDF]

The Journal of Neuroscience, 2008
Astrocytes are electrically nonexcitable cells that communicate by means of Ca2+signaling. Long-distance intercellular Ca2+waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does ...
Jian, Kang, Ning, Kang, Ditte, Lovatt, Arnulfo, Torres, Zhuo, Zhao, Jane, Lin, Maiken, Nedergaard   +6 more
openaire   +2 more sources

Rational design of new NO and redox sensitivity into connexin26 hemichannels [PDF]

Open Biology, 2015
CO2 directly opens hemichannels of connexin26 (Cx26) by carbamylating K125, thereby allowing salt bridge formation with R104 of the neighbouring subunit in the connexin hexamer.
Louise Meigh, Daniel Cook, Jie Zhang, Nicholas Dale   +3 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor

Pharmaceuticals, 2020
To understand the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), we studied functional abnormalities of glutamatergic transmission in thalamocortical pathway from reticular thalamic nucleus (RTN ...
Kouji Fukuyama, Masashi Fukuzawa, Motohiro Okada   +2 more
doaj   +1 more source

Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells [PDF]

, 2015
The postnatal subventricular zone (SVZ) lining the walls of the lateral ventricles contains neural progenitor cells (NPCs) that generate new olfactory bulb interneurons.
Escamilla, Rosalba, Fernández, Paola, Pastor Loro, Ángel Manuel, Rodríguez Matarredona, Esperanza, Sáez, Juan Carlos, Talaverón Aguilocho, Rocío   +5 more
core   +1 more source