Results 101 to 110 of about 6,791 (202)
Radiotherapy damages bone and disrupts osteocyte function, yet mechanically mediated protection remains largely unexplored. This study demonstrates that low‐magnitude, high‐frequency (LMHF) vibration mitigates irradiated osteocyte apoptosis, restores their ability to regulate breast cancer extravasation, and acts synergistically with radiotherapy to ...
Xin Song +7 more
wiley +1 more source
Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]
Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
core +1 more source
Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro [PDF]
Connexin26 (Cx26) mutations underlie human pathologies ranging from hearing loss to keratitis ichthyosis deafness (KID) syndrome. Cx26 hemichannels are directly gated by CO2 and contribute to the chemosensory regulation of breathing.
Cook, Jonathan +3 more
core +1 more source
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo +18 more
wiley +1 more source
Mutations of the GJB2 gene encoding the connexin 26 (Cx26) gap junction protein, which is widelyexpressed in the inner ear, are the primary cause of hereditary non–syndromic hearing loss in severalpopulations.
Francesco eZonta +7 more
doaj +1 more source
The Interaction of Biological Factors with Mechanical Signals in Bone Adaptation: Recent Developments [PDF]
Mechanotransduction in bone is fundamental to proper skeletal development. Deficiencies in signaling mechanisms that transduce physical forces to effector cells can have severe consequences for skeletal integrity.
Robling, Alexander G.
core +1 more source
Electrical Synapses Contribute to Sleep‐Dependent Declarative Memory Retention
Blocking electrical synapses (gap junctions) in healthy humans by mefloquine impaired the sleep‐dependent retention of verbal declarative memory and improved sensorimotor memory consolidation irrespective of sleep. Mefloquine also disrupted the coupling of sleep spindles to EEG slow oscillations in humans but did not affect hippocampal sharp‐wave ...
Gordon B. Feld +9 more
wiley +1 more source
Clozapine (CLZ) is a gold-standard antipsychotic against treatment-refractory schizophrenia, but is one of the most toxic antipsychotic agents. Pharmacological mechanisms of the double-edged sword clinical action of CLZ remain to be clarified. To explore
Kouji Fukuyama +4 more
doaj +1 more source
Struktur dan Regulasi Connexin43 dalam Komunikasi Antar Sel Otot Jantung [PDF]
Jantung memiliki kerja yang sangat kompleks. Salah satu hal yang memungkinkan jantung berfungsi baik adalah komunikasi antar sel. Di dalam jantung, komunikasi antar sel otot jantung terjalin antara lain melalui kanal gap junction.
Chondro, Fransisca
core +1 more source
ABSTRACT Aim Under certain conditions, infection‐induced inflammation may activate reparative processes to form a hard tissue barrier against microbial invasion. Autophagy participates in odontogenic differentiation during inflammation in vitro, but its role in pulp repair remains unclear.
Peiling Hu +7 more
wiley +1 more source

