Results 111 to 120 of about 6,791 (202)

Paracrine signaling through plasma membrane hemichannels

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Plasma membrane hemichannels composed of connexin (Cx) proteins are essential components of gap junction channels but accumulating evidence suggests functions of hemichannels beyond the communication provided by junctional channels. Hemichannels not incorporated into gap junctions, called unapposed hemichannels, can open in response to a variety of ...
Wang, Nan, De Bock, Marijke, Decrock, Elke, Bol, Melissa, Gadicherla, Ashish, Vinken, Mathieu, Rogiers, Vera, Bukauskas, Felix, Bultynck, Geert, Leybaert, Luc   +9 more
openaire   +3 more sources

The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring

Frontiers in Cellular Neuroscience, 2019
Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
Carolina E. Chávez, Juan E. Oyarzún, Beatriz C. Avendaño, Luis A. Mellado, Carla A. Inostroza, Tanhia F. Alvear, Juan A. Orellana   +6 more
doaj   +1 more source

Modulation of Cx46 hemichannels by nitric oxide

American Journal of Physiology-Cell Physiology, 2009
Gap-junction hemichannels are composed of six protein subunits (connexins). Undocked hemichannels contribute to physiological autocrine/paracrine cell signaling, including release of signaling molecules, cell-volume regulation, and glucose uptake.
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Conductive and Kinetic Properties of Connexin45 Hemichannels Expressed in Transfected HeLa Cells [PDF]

, 2018
Human HeLa cells transfected with mouse connexin Cx45 were used to examine the conductive and kinetic properties of Cx45 hemichannels. The experiments were carried out on single cells using a voltage-clamp method.
Bader, P., Weingart, R.
core  

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity [PDF]

, 2018
The precise contribution of astrocytes in neuroinflammatory process occurring in Parkinson's disease (PD) is not well characterized. In this study, using GR(Cx30CreERT2) mice that are conditionally inactivated for glucocorticoid receptor (GR) in ...
A Dey, A Klegeris, A Koulakoff, A Nimmerjahn, Anne-Claire Compagnion, Annette Koulakoff, AR Clark, B Mirza, C Giaume, C Giaume, C Giaume, C Schnell, Chenju Yi, Christian Giaume, CK Glass, CK Liao, CL Jones, EC Hirsch, EC Hirsch, Etienne C. Hirsch, F Ros-Bernal, F Tronche, Frank W Pfrieger, François Tronche, G Charron, GG Kovacs, H Braak, H Hirase, J Miklossy, J Waak, K Bosscher De, K Saijo, K Sathe, K Wakabayashi, L Leybaert, Layal Maatouk, LM Chow, Luc Leybaert, M Bock De, M Bock De, M Slezak, MA Carrillo-de Sauvage, MA Retamal, Maria-Angeles Carrillo-de Sauvage, MD Muzumdar, MV Sofroniew, N Esen, N Wang, N Wang, P Damier, Pascal Ezan, PJ Barnes, PL McGeer, R Newton, S Vyas, SA Schneider, Sheela Vyas, Stéphane Hunot, V Abudara, V Abudara, W Liu, Y Chinenov, Y Ouchi, YJ Song   +63 more
core   +4 more sources

Mind the gap: connexins and cell–cell communication in the diabetic kidney [PDF]

, 2015
Connexins, assembled as a hexameric connexon, form a transmembrane hemichannel that provides a conduit for paracrine signalling of small molecules and ions to regulate the activity and function of adjacent cells.
A Abed, A Awad, A Cove-Smith, A Kurtz, A Mendoza-Naranjo, A Pfenniger, A Sipos, AF Li, AF Li, BN Giepmans, C Qiu, C Wagner, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, CE Hills, Claire E. Hills, CM Wang, CS Wright, D Bosco, D Lu, DW Laird, E Yaoita, F Hanner, F Mumtaz, G Sahu, Gareth W. Price, GS Goldberg, GS Hillis, GS Hillis, I Loeffler, J Gilleron, J Kronengold, J Wada, J Yao, J Yao, J Yao, J Zhang, JA Haefliger, JA Haefliger, JA Wright, JC Herve, JH Zhang, K Fujimoto, K Sawai, L Gal Le, L Liu, M Dalla Vestra, M Firouzi, M Gerl, M Oppermann, M Oyamada, MA Retamal, MS Nielsen, MW Bobbie, N Defamie, N Krattinger, N Wang, P Svenningsen, Paul E. Squires, PD Lampe, Q Yan, R Hernández-Salinas, R Hirschberg, RM Mege, S Tsuchida, SP Prabhakar, SS Prabhakar, T Inoguchi, T Morioka, T Sato, T Takenaka, T Takenaka, T Tien, WM Jongen, X Xie, X Zhang, Y Liu, Y Suzaki, YC Lee   +82 more
core   +1 more source

Connexin-based gap junction hemichannels: Gating mechanisms

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2005
Connexins (Cxs) form hemichannels and gap junction channels. Each gap junction channel is composed of two hemichannels, also termed connexons, one from each of the coupled cells. Hemichannels are hexamers assembled in the ER, the Golgi, or a post Golgi compartment. They are transported to the cell surface in vesicles and inserted by vesicle fusion, and
Saez, JC, Retamal, MA, Basilio, D, Bukauskas, FF, Bennett, MVL   +4 more
openaire   +5 more sources

ATP releasing connexin 30 hemichannels mediate flow-induced calcium signaling in the collecting duct [PDF]

, 2013
ATP in the renal tubular fluid is an important regulator of salt and water reabsorption via purinergic calcium signaling that involves the P2Y(2) receptor, ENaC, and AQP2.
Burford, James L, Peti-Peterdi, János, Svenningsen, Per   +2 more
core   +1 more source

Electrophysiology of Single and Aggregate Cx43 Hemichannels

PLoS ONE, 2012
Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals, passing dissolved solutes and small signaling molecules between cells in a coordinated fashion ...
Cole Brokamp, Jacob Todd, Carlo Montemagno, David Wendell   +3 more
openaire   +3 more sources

Induction of Connexin-hemichannel Opening

BIO-PROTOCOL, 2014
Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight. Cxs are expressed in many cell types, e.g. epithelial cells, astrocytes and immune cells.
Puhar, Andrea, Sansonetti, Philippe
openaire   +3 more sources