Results 11 to 20 of about 6,791 (202)

Hemichannels: new roles in astroglial function [PDF]

Frontiers in Physiology, 2014
The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the release of gliotransmitters.
Jimmy eStehberg, Juan Andrés Orellana
doaj   +4 more sources

Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte-derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes. [PDF]

Diabet Med
Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
Ward JK, Shah MU, Lee K, Squires PE, Hills CE.   +4 more
europepmc   +2 more sources

Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease. [PDF]

PLoS ONE, 2011
Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, including amyotrophic lateral sclerosis and Alzheimer's disease.
Hideyuki Takeuchi, Hiroyuki Mizoguchi, Yukiko Doi, Shijie Jin, Mariko Noda, Jianfeng Liang, Hua Li, Yan Zhou, Rarami Mori, Satoko Yasuoka, Endong Li, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Jun Sato, Koji Yamanaka, Gen Sobue, Tetsuya Mizuno, Akio Suzumura   +18 more
doaj   +1 more source

Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. [PDF]

PLoS ONE, 2013
Reduced astrocytic gap junctional communication and enhanced hemichannel activity were recently shown to increase astroglial and neuronal vulnerability to neuroinflammation.
Pablo J Sáez, Juan A Orellana, Natalia Vega-Riveros, Vania A Figueroa, Diego E Hernández, Juan F Castro, Andrés D Klein, Jean X Jiang, Silvana Zanlungo, Juan C Sáez   +9 more
doaj   +1 more source

Carboxyfluorescein Dye Uptake to Measure Connexin-mediated Hemichannel Activity in Cultured Cells

Bio-Protocol, 2021
Connexins are membrane bound proteins that facilitate direct and local paracrine mediated cell-to-cell communication through their ability to oligomerise into hexameric hemichannels.
Joe Potter, Gareth Price, Chelsy Cliff, Bethany Williams, Claire Hills, Paul Squires   +5 more
doaj   +1 more source

Following Tracks of Hemichannels [PDF]

Cell Communication & Adhesion, 2003
It has been suggested that plasma membrane-bound hemichannels perform physiological and pathophysiological functions per se. Such functions require the presence of hemichannels on the cell surface and their accessibility to the extracellular environment for at least some limited period of time.
Rolf, Dermietzel, Carola, Meier, Feliksas, Bukauskas, David C, Spray   +3 more
openaire   +3 more sources

Connexin hemichannel inhibition ameliorates epidermal pathology in a mouse model of keratitis ichthyosis deafness syndrome

Scientific Reports, 2021
Mutations in five different genes encoding connexin channels cause eleven clinically defined human skin diseases. Keratitis ichthyosis deafness (KID) syndrome is caused by point mutations in the GJB2 gene encoding Connexin 26 (Cx26) which result in ...
Caterina Sellitto, Leping Li, Thomas W. White   +2 more
doaj   +1 more source

Hunting for connexin hemichannels [PDF]

FEBS Letters, 2014
Connexin hemichannels (connexons) are building blocks of gap junctions but also function as free unapposed channels, which has become an active field of research. Defining functions of hemichannels and their involvement in any biological event requires ruling out possible participation of other channels that share biophysical and regulatory properties,
Saez, Juan C., Leybaert, Luc
openaire   +4 more sources

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury

Cell Communication and Signaling, 2023
Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
Elena Roger, Christos E. Chadjichristos, Panagiotis Kavvadas, Gareth W. Price, Chelsy L. Cliff, Safia Hadjadj, Jessy Renciot, Paul E. Squires, Claire E. Hills   +8 more
doaj   +1 more source

Connexin hemichannels in the lens [PDF]

Frontiers in Physiology, 2014
The normal function and survival of cells in the avascular lens is facilitated by intercellular communication through an extensive network of gap junctions formed predominantly by three connexins (Cx43, Cx46, and Cx50). In expression systems, these connexins can all induce hemichannel currents, but other lens proteins (e.g., pannexin1) can also induce ...
Beyer, Eric C., Berthoud, Viviana M.
openaire   +3 more sources