Results 31 to 40 of about 6,791 (202)
Connexin 43 in Mitochondria: What Do We Really Know About Its Function?
Frontiers in Physiology, 2022 Connexins are known for their ability to mediate cell-cell communication via gap junctions and also form hemichannels that pass ions and molecules over the plasma membrane when open.
Kerstin Boengler +3 more
doaj +1 more source
Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]
, 2019 Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An +8 more
core +2 more sources
Structure and permeability of ion-channels by integrated AFM and waveguide TIRF microscopy. [PDF]
, 2014 Membrane ion channels regulate key cellular functions and their activity is dependent on their 3D structure. Atomic force microscopy (AFM) images 3D structure of membrane channels placed on a solid substrate.
Arce, Fernando Teran +5 more
core +2 more sources
Gap Junction-Dependent and -Independent Functions of Connexin43 in Biology
Biology, 2022 For the first time in animal evolution, the emergence of gap junctions allowed direct exchanges of cellular substances for communication between two cells.
Yi Zhu
doaj +1 more source
Mechanisms Underlying Connexin Hemichannel Activation in Disease [PDF]
International Journal of Molecular Sciences, 2021 Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their activation is associated with the onset and dissemination of disease.
Raf Van Campenhout +5 more
openaire +3 more sources
Biology, 2021 Intracerebral hemorrhage (ICH) is a devastating disease with high mortality and morbidity; the mortality rate ranges from 40% at 1 month to 54% at 1 year; only 12–39% achieve good outcomes and functional independence.
Yan Zhang +6 more
doaj +1 more source
Frontiers in Immunology, 2018 The present work was done to elucidate whether hemichannels of a cell line derived from endothelial cells are affected by pro-inflammatory conditions (high glucose and IL-1β/TNF-α) known to lead to vascular dysfunction.
Juan C. Sáez +12 more
doaj +1 more source
Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond [PDF]
, 2014 Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Bultynck, Geert +4 more
core +2 more sources
Possible role of hemichannels in cancer [PDF]
Frontiers in Physiology, 2014 In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors. Alteration of Cxs and Panxs in cancer cells can be due to genetic, epigenetic and post-transcriptional/post-translational events.
Kurt Alex Schalper +3 more
openaire +3 more sources
Astroglial Connexins in Neurodegenerative Diseases
Frontiers in Molecular Neuroscience, 2021 Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive ...
Xiaomin Huang +8 more
doaj +1 more source