Results 41 to 50 of about 6,791 (202)

Design and Characterization of a Human Monoclonal Antibody that Modulates Mutant Connexin 26 Hemichannels Implicated in Deafness and Skin Disorders [PDF]

, 2017
Background: Mutations leading to changes in properties, regulation, or expression of connexin-made channels have been implicated in 28 distinct human hereditary diseases.
Andrea Carrer, Anna M. Salvatore, Anselmi, Barbas, Barbas, Beck, Bedner, Beltramello, Bennett, Berendsen, Best, Bosen, Bosen, Boukamp, Breitling, Brenke, Bruzzone, Bujak, Burton, Ceriani, Chen, Chiara Nardin, Chiara Peres, Clackson, Clair, Comeau, Damiano Buratto, Darden, De Luca, DeVries, Djalilian, Dupont, Emsley, Esseltine, Essenfelder, Fabio Mammano, Fasciani, Federico Ceriani, Ferdinando Scavizzi, Flavia Mazzarda, Forge, Francesca Bruno, Francesco Zonta, Frenzel, Gaia Ziraldo, Garcia, Garcia, Gerido, Giulia Crispino, Goodenough, Guang Yang, Gumbart, Hernandez, Holliger, Housley, Jackson, Johnson, Jun Liao, Kanaporis, Kopecki, Larkin, Lee, Lee, Lefranc, Leibovici, Lerner, Levit, Liang Xu, Lipes, Maeda, Majumder, Marcello Raspa, Martin, Mavilio, McCafferty, McCoy, Mese, Mhaske, Minor, Murshudov, Niessen, Ortolano, Peixiang Ma, Perisic, Pronk, Remington, Retamal, Richard A. Lerner, Riquelme, Rodriguez, Rodriguez-Boulan, Saez, Saez, Sanchez, Sanchez, Schutz, Schutz, Shanshan Wang, Sheng Li, Sichun Xie, Srinivas, Stauffer, Stong, Tamai, Thomas, Tolar, Tritsch, Uitto, Veronica Zorzi, Wang, Wangemann, Weber, Wei Wang, Wilcox, Wingard, Wong, Wu, Xiao Liu, Xuemei Yang, Youjun Chu, Zhang, Zhao, Zhao, Zhihu Qu, Zong, Zonta   +125 more
core   +6 more sources

The Role of Connexin 43 and Pannexin 1 During Acute Inflammation

Frontiers in Physiology, 2020
During acute inflammation, the recruitment of leukocytes from the blood stream into the inflamed tissue is a well-described mechanism encompassing the interaction of endothelial cells with leukocytes allowing leukocytes to reach the site of tissue injury
Petra Kameritsch, Petra Kameritsch, Kristin Pogoda   +2 more
doaj   +1 more source

Simulations on Simple Models of Connexin Hemichannels Indicate That Ca²⁺ Blocking Is Not a Pure Electrostatic Effect

Membranes, 2021
Connexin hemichannels allow the unspecific but regulated interchange of molecules from ions to second messenger and ATP, between the eukariotic cell and its extracellular space.
Felipe Villanelo, Jorge Carrasco, Joaquin Jensen-Flores, Jose Antonio Garate, Tomas Perez-Acle   +4 more
doaj   +1 more source

What's the Function of Connexin 32 in the Peripheral Nervous System? [PDF]

, 2018
Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), the second most common form of hereditary motor and sensory neuropathy and a demyelinating
Bortolozzi, Mario
core   +1 more source

Identification of a New Mutation p.P88L in Connexin 50 Associated with Dominant Congenital Cataract

Frontiers in Cell and Developmental Biology, 2022
Congenital hereditary cataract is genetically heterogeneous and the leading cause of visual impairment in children. Identification of hereditary causes is critical to genetic counselling and family planning.
Aixia Jin, Qingqing Zhao, Shuting Liu, Zi-bing Jin, Shuyan Li, Mengqing Xiang, Mingbing Zeng, Mingbing Zeng, Kangxin Jin, Kangxin Jin   +9 more
doaj   +1 more source

Connexin43 hemichannels in satellite glial cells, can they influence sensory neuron activity? [PDF]

, 2017
Indexación: Scopus.In this review article, we summarize the current insight on the role of Connexin- and Pannexin-based channels as modulators of sensory neurons.
Alcayaga, J., Retamal, M.A., Riquelme, M.A., Stehberg, J.   +3 more
core   +1 more source

Connexin hemichannels and cochlear function [PDF]

Neuroscience Letters, 2019
Connexins play vital roles in hearing, including promoting cochlear development and sustaining auditory function in the mature cochlea. Mutations in connexins expressed in the cochlear epithelium, Cx26 and Cx30, cause sensorineural deafness and in the case of Cx26, is one of the most common causes of non-syndromic, hereditary deafness.
openaire   +2 more sources

Dye-uptake Experiment through Connexin Hemichannels

Bio-Protocol, 2014
Connexins (Cxs) are integral membrane proteins of vertebrates that associate to form hexameric transmembrane channels, named hemichannels. Twenty-one Cx types have been described, which are named according to their molecular weight.
Andrea Puhar, Philippe Sansonetti
doaj   +1 more source

Upregulated Connexin 43 Induced by Loss-of-Functional S284L-Mutant α4 Subunit of Nicotinic ACh Receptor Contributes to Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy

Pharmaceuticals, 2020
To study the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), this study determined functional abnormalities of glutamatergic transmission in the thalamocortical motor pathway, from the reticular ...
Kouji Fukuyama, Masashi Fukuzawa, Ruri Okubo, Motohiro Okada   +3 more
doaj   +1 more source

Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading

eLife, 2022
Mechanical stimulation, such as physical exercise, is essential for bone formation and health. Here, we demonstrate the critical role of osteocytic Cx43 hemichannels in anabolic function of bone in response to mechanical loading.
Dezhi Zhao, Manuel A Riquelme, Teja Guda, Chao Tu, Huiyun Xu, Sumin Gu, Jean X Jiang   +6 more
doaj   +1 more source