Results 51 to 60 of about 6,791 (202)

Connexins in Lung Cancer and Brain Metastasis

Frontiers in Oncology, 2020
Connexins (Cxs) are involved in the brain metastasis of lung cancer cells. Thus, it is necessary to determine whether gap junction-forming Cxs are involved in the communication between lung cancer cells and the host cells, such as endothelial cells ...
Kai-Jun Luo, Kai-Jun Luo, Chang-Xu Chen, Chang-Xu Chen, Jia-Peng Yang, Jia-Peng Yang, Yun-Chao Huang, Yun-Chao Huang, Eduardo R. Cardenas, Jean X. Jiang   +9 more
doaj   +1 more source

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock [PDF]

, 2019
Upon intravenous injection of tumour necrosis factor (TNF) in mice, a systemic inflammatory response syndrome (SIRS) is initiated, characterized by an acute cytokine storm and induction of vascular hyperpermeability.
Czekaj, Aleksandra, De Smet, Maarten, Declercq, Wim, Decrock, Elke, Delvaeye, Tinneke, Gonçalves, Amanda, Krysko, Dmitri, Lemeire, Kelly, Leybaert, Luc, Vandenabeele, Peter, Vandenbroucke, Roosmarijn, Verwaerde, Stijn   +11 more
core   +2 more sources

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions

Frontiers in Neurology, 2020
Ischemic stroke is a multi-factorial cerebrovascular disease with high worldwide morbidity and mortality. In the past few years, multiple studies have revealed the underlying mechanism of ischemia/reperfusion injury, including calcium overload, amino ...
Zhen Liang, Xu Wang, Yulei Hao, Lin Qiu, Yingyue Lou, Yaoting Zhang, Di Ma, Jiachun Feng   +7 more
doaj   +1 more source

Connexin 43 hemichannels and related diseases. [PDF]

Antib Ther
Abstract Connexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels. While gap junctions are prevalent in organs like the heart and liver, hemichannels are found in specific cell types, such as astrocytes and osteocytes. They
Zhang Y, Acosta FM, Jiang JX.
europepmc   +3 more sources

Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity

Biomolecules, 2023
Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichannel is
Francisca García-Rojas, Carolina Flores-Muñoz, Odra Santander, Pamela Solis, Agustín D. Martínez, Álvaro O. Ardiles, Marco Fuenzalida   +6 more
doaj   +1 more source

Diseases associated with leaky hemichannels

Frontiers in Cellular Neuroscience, 2015
Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication. While HCs connect the intracellular compartment with the extracellular milieu, GJCs allow the interchange of molecules between cytoplasm of two contacting cells.
Retamal, Mauricio A., Reyes, Edison P., García, Isaac E., Pinto, Bernardo, Martínez, Agustín D., González, Carlos   +5 more
openaire   +3 more sources

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

Frontiers in Cellular Neuroscience, 2018
Connexin 43 (Cx43) widely exists in all components of the neurovascular unit (NVU) and is a constituent of gap junctions and hemichannels. In physiological states, gap junctions are open for regular intercellular communication, and the hemichannels ...
Yingzhu Chen, Yingzhu Chen, Liangzhu Wang, Liangzhu Wang, Lingling Zhang, Lingling Zhang, Beilei Chen, Beilei Chen, Liu Yang, Liu Yang, Xiaobo Li, Xiaobo Li, Xiaobo Li, Yuping Li, Yuping Li, Hailong Yu, Hailong Yu, Hailong Yu, Hailong Yu   +18 more
doaj   +1 more source

Voltage-dependent facilitation of Cx46 hemichannels

American Journal of Physiology-Cell Physiology, 2010
Gap junction channels are formed by two hemichannels in series (one from each neighboring cell), which are in turn connexin hexamers. Under normal conditions, hemichannels at the plasma membrane are mostly closed but can be opened by changes in membrane voltage, extracellular divalent ion concentration, phosphorylation, pH, and redox potential ...
Retamal, Mauricio A., Yin, ShengYong, Altenberg, Guillermo A., Reuss, Luis   +3 more
openaire   +5 more sources

Connexin 43 hemichannels and prostaglandin E2 release in anabolic function of the skeletal tissue to mechanical stimulation

Frontiers in Cell and Developmental Biology, 2023
Bone adapts to changes in the physical environment by modulating remodeling through bone resorption and formation to maintain optimal bone mass. As the most abundant connexin subtype in bone tissue, connexin 43 (Cx43)-forming hemichannels are highly ...
Dezhi Zhao, Dezhi Zhao, Dezhi Zhao, Jiawei Wu, Francisca M. Acosta, Huiyun Xu, Jean X. Jiang   +6 more
doaj   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source