Results 71 to 80 of about 6,791 (202)

Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion

Pharmaceuticals, 2021
Accumulating neuropsychopharmacological evidence has suggested that functional abnormalities of astroglial transmission and protein kinase B (Akt) contribute to the pathophysiology and/or pathomechanisms of several neuropsychiatric disorders, such as ...
Kouji Fukuyama, Motohiro Okada
doaj   +1 more source

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice [PDF]

, 2017
While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress.
Cogliati, Bruno, Crespo Yanguas, Sara, da Silva, Tereza Cristina, de Castro, Inar Alves, Decrock, Elke, Felisbino, Daniele Aparecida, Govoni, Veronica Mollica, Leclercq, Isabelle, Leybaert, Luc, Lima, Andressa, Maes, Michaël, Nogueira, Marina Sayuri, Pereira, Isabel Veloso Alves, Rodrigues, Robim Marcelino, Vinken, Mathieu, Willebrords, Joost   +15 more
core   +2 more sources

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Differential sensitivity of brainstem vs cortical astrocytes to changes in pH reveals functional regional specialization of astroglia [PDF]

, 2013
Astrocytes might function as brain interoceptors capable of detecting different (chemo)sensory modalities and transmitting sensory information to the relevant neural networks controlling vital functions.
Castaldo, C, Gourine, A, Kasimov, V, Kasparov, Sergey, Larina, O, Marina, N, Patrushev, M   +6 more
core   +2 more sources

Cx26 keratitis ichthyosis deafness syndrome mutations trigger alternative splicing of Cx26 to prevent expression and cause toxicity in vitro [PDF]

, 2019
The Cx26 mRNA has not been reported to undergo alternative splicing. In expressing a series of human keratitis ichthyosis deafness (KID) syndrome mutations of Cx26 (A88V, N14K and A40V), we found the production of a truncated mRNA product.
Cook, Jonathan P., Dale, Nicholas, de Wolf, Elizabeth   +2 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Calcium Regulation of Connexin Hemichannels

International Journal of Molecular Sciences
Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are of paramount importance for intercellular communication. In physiological conditions, HCs can form gap junction (GJ) channels, providing a direct diffusive path between neighbouring cells.
Erva Bayraktar, Diego Lopez-Pigozzi, Mario Bortolozzi   +2 more
openaire   +3 more sources

Connexin43 Hemichannel-Mediated Regulation of Connexin43

PLoS ONE, 2013
Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we ...
Kai Li, Yuan Chi, Kun Gao, Qiaojing Yan, Hiroyuki Matsue, Masayuki Takeda, Masanori Kitamura, Jian Yao   +7 more
openaire   +4 more sources

Connexin 43 Modulates β‐Catenin–Dependent Transcription and Secretory Responses to Oscillatory Fluid Flow in Osteocytes

Journal of Orthopaedic Research, Volume 44, Issue 3, March 2026.
ABSTRACT Osteocytes detect and transduce mechanical cues into biochemical signals that regulate bone remodeling. Connexin 43 (Cx43) is the predominant gap junction protein in osteocytes, but its role in β‐catenin signaling during mechanical loading remains unclear.
Michael A. Friedman, Yue Zhang, Nathanael Neece, Caleb Ryan, Chris Brunkhorst, Henry J. Donahue   +5 more
wiley   +1 more source

Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice

MedComm, Volume 7, Issue 3, March 2026.
PGC‑1α downregulation in hippocampal astrocytes disrupts ATP release and reduces connexin 43 (CX43) expression, impairing neuro‑glial communication. This promotes enhanced fear memory retrieval in PTSD. Chemogenetic activation of astrocytes or PGC‑1α agonist treatment rescues both CX43 expression and fear behavior, identifying astrocytic PGC‑1α/CX43 as
Juan Wang, Xiaoyu Chen, Daokang Chen, Shaojie Yang, Jingji Wang, Ming Chen, Guoqi Zhu   +6 more
wiley   +1 more source