Results 81 to 90 of about 6,791 (202)

The Role of Connexin and Pannexin Channels in Perinatal Brain Injury and Inflammation

Frontiers in Physiology, 2019
Perinatal brain injury remains a major cause of death and life-long disability. Perinatal brain injury is typically associated with hypoxia-ischemia and/or infection/inflammation.
Kelly Q. Zhou, Colin R. Green, Laura Bennet, Alistair J. Gunn, Joanne O. Davidson   +4 more
doaj   +1 more source

Current and Emerging Pharmacologic Therapies for Diabetic Retinopathy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin levels, hypertension, and dyslipidemia, with rapid glucose reduction also increasing risk for developing ...
Jennifer N. Clements, Julia Mesawich, Cassandra Twisdale   +2 more
wiley   +1 more source

Nature of plasmalemmal functional “hemichannels”

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
The molecular identity of the protein forming "hemichannels" at non-junctional membranes is disputed. The family of gap junction proteins, innexins, connexins, and pannexins share several common features, including permeability characteristics and sensitivity to blocking agents.
openaire   +2 more sources

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke [PDF]

, 2019
Connexin43 (Cx43) function is influenced by kinases that phosphorylate specific serine sites located near its C-terminus. Stroke is a powerful inducer of kinase activity, but its effect on Cx43 is unknown. We investigated the impact of wild-type (WT) and
Bechberger, John F, De Bock, Marijke, Freitas-Andrade, Moises, Lampe, Paul D, Leybaert, Luc, Naus, Christian C, Wang, Nan   +6 more
core   +2 more sources

Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Paweł Hanus, Dorota Frydecka, Michał Ślęzak   +2 more
wiley   +1 more source

GJB6 missense variant in a Labrador Retriever with paw pad hyperkeratosis

Animal Genetics, Volume 57, Issue 1, February 2026.
Abstract Palmoplantar keratoderma in humans is a condition defined by an abnormally thickened cornified skin layer on the hands and feet. In animals, the corresponding disease is commonly termed paw pad hyperkeratosis. It can be acquired due to repeated trauma, infections, cancer, or inflammatory dermatoses, or inherited due to pathogenic variants in ...
Stefan J. Rietmann, Joseph Malatos, Vidhya Jagannathan, Tosso Leeb   +3 more
wiley   +1 more source

A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death [PDF]

, 2018
Erythrokeratodermia variabilis et progressiva (EKV-P) is caused by mutations in either the GJB3 (Cx31) or GJB4 genes (Cx30.3). We identified a rare GJB3 missense mutation, c.134G>A (p.G45E), in two unrelated patients and investigated its cellular ...
Alboulshi, A. K., Broers, M. R., Brouns, G. H., Coull, Barry. J., Easton, J. A., Kamps, M. A. F., Martin, P. E., Oji, V., van Geel, M., van Steensel, M. A. M.   +9 more
core   +5 more sources

Pannexin channels are not gap junction hemichannels [PDF]

Channels, 2011
Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins, connexins. However, the functional role for the pannexin oligomers, or pannexons, is different from
Gina E, Sosinsky, Daniela, Boassa, Rolf, Dermietzel, Heather S, Duffy, Dale W, Laird, Brian, MacVicar, Christian C, Naus, Silvia, Penuela, Eliana, Scemes, David C, Spray, Roger J, Thompson, Hong-Bo, Zhao, Gerhard, Dahl   +12 more
openaire   +2 more sources

Cataract-causing mutation of human connexin 46 impairs gap junction, but increases hemichannel function and cell death. [PDF]

PLoS ONE, 2013
Connexin channels play a critical role in maintaining metabolic homeostasis and transparency of the lens. Mutations in connexin genes are linked to congenital cataracts in humans.
Qian Ren, Manuel A Riquelme, Ji Xu, Xiang Yan, Bruce J Nicholson, Sumin Gu, Jean X Jiang   +6 more
doaj   +1 more source

The p.Cys169Tyr variant of connexin 26 is not a polymorphism [PDF]

, 2015
Mutations in the GJB2 gene, which encodes the gap junction protein connexin 26 (Cx26), are the primary cause of hereditary prelingual hearing impairment. Here, the p.Cys169Tyr missense mutation of Cx26 (Cx26C169Y), previously classified as a polymorphism,
Abdulhadi, Khalid, Alkowari, Moza, Badii, Ramin, Buratto, Damiano, Crispino, Giulia, Gasparini, Paolo, Girotto, Giorgia, Mammano, Fabio, Morgan, Anna, Zonta, Francesco   +9 more
core   +1 more source